化工进展 ›› 2024, Vol. 43 ›› Issue (6): 3374-3385.DOI: 10.16085/j.issn.1000-6613.2023-2103
• 资源与环境化工 • 上一篇
吕青檐1(), 高汉文1, 谢昆谕1, 范冬青1, 黄龙1(
), 陈志强2
收稿日期:
2023-11-30
修回日期:
2024-01-09
出版日期:
2024-06-15
发布日期:
2024-07-02
通讯作者:
黄龙
作者简介:
吕青檐(1996—),女,硕士研究生,研究方向为混合菌群合成生物可降解塑料。E-mail:2784501665@qq.com。
基金资助:
LYU Qingyan1(), GAO Hanwen1, XIE Kunyu1, FAN Dongqing1, HUANG Long1(
), CHEN Zhiqiang2
Received:
2023-11-30
Revised:
2024-01-09
Online:
2024-06-15
Published:
2024-07-02
Contact:
HUANG Long
摘要:
聚羟基脂肪酸酯(polyhydroxyalkanoates, PHA)是一种可完全生物降解材料,具有与传统塑料相似的机械性能,有望替代石油基塑料从源头上解决塑料危机。混合菌群利用廉价的废弃有机物合成PHA,对降低PHA的生产成本,实现废弃有机物的减量化和资源化具有重要意义。底物多样化是混合菌群PHA合成工艺的鲜明特点。本文首先剖析了混合菌群PHA合成系统中底物类型的重要性,进而综述了混合菌群利用不同类型废弃有机物合成PHA的现状,指出废弃有机物基质复杂易造成代谢偏移、产品产量及性能难以精准调控等关键问题。并对混合菌群利用废弃有机物合成PHA的研究进行了展望,需在明晰废弃有机物基质组分基础上,针对性优化底物水解酸化工艺、开发PHA产物性能调控技术和绿色低损耗的产物提纯工艺,最终构建高效能的PHA混合菌群工艺系统。
中图分类号:
吕青檐, 高汉文, 谢昆谕, 范冬青, 黄龙, 陈志强. 废弃有机物用于混合菌群合成PHA的利用现状与挑战[J]. 化工进展, 2024, 43(6): 3374-3385.
LYU Qingyan, GAO Hanwen, XIE Kunyu, FAN Dongqing, HUANG Long, CHEN Zhiqiang. Current situation and challenges of mixed culture polyhydroxyalkanoate (PHA) production using waste organics[J]. Chemical Industry and Engineering Progress, 2024, 43(6): 3374-3385.
底物摄取过程 | 化学计量式(以Cmol计) |
---|---|
乙酸 | CH2O+ATP |
丙酸 | CH2O2/3+0.67ATP |
丁酸 | CH2O0.5+0.5ATP |
戊酸 | CH2O2/5+0.4ATP |
表1 不同VFA合成PHA前体物质的化学计量式[28]
底物摄取过程 | 化学计量式(以Cmol计) |
---|---|
乙酸 | CH2O+ATP |
丙酸 | CH2O2/3+0.67ATP |
丁酸 | CH2O0.5+0.5ATP |
戊酸 | CH2O2/5+0.4ATP |
底物类型 | 有效底物组分 | 产PHA优势菌 | 合成PHA类型 | 底物转化 效率 | 最大PHA 合成能力 | PHA产量 | PHA转化率 | 参考文献 |
---|---|---|---|---|---|---|---|---|
废弃奶牛粪便 | 蛋白质、糖、 脂肪、粗纤维 (需发酵) | 混合菌群 (甲基杆菌科属、 动胶菌属) | PHB、PHV | — | 90.70% | — | 1.12Cmmol /Cmmol | [ |
废弃奶酪乳清 | 乳糖、脂肪、 蛋白质(需发酵) | 混合菌群 (未明确组成) | HB(70.00%)、HV(30.00%) | — | 60.00% | 7.80g/L | — | [ |
废弃奶酪乳清 | 乳糖、脂肪、 蛋白质(需发酵) | 混合菌群 (未明确组成) | HB(89.00%)、HV(11.00%) | 0.72gCOD /gCOD | 43.00% | — | 0.85Cmol/Cmol | [ |
废弃奶酪乳清 | 乳糖、脂肪、 蛋白质(需发酵) | 混合菌群 (未明确组成) | HB(60.00%)、HV(40.00%) | 0.60Cmmol /Cmmol | 81.40%±0.57% | 0.42mgCOD /mgCOD | 0.80Cmmol /Cmmol | [ |
废弃奶酪乳清 | 乳糖、脂肪、 蛋白质(需发酵) | 混合菌群 (钩虫贪铜菌) | 3HB(94.00%)、HV(6.00%) | 0.85g/g | 71.00% | — | 0.60g/g | [ |
废弃糖蜜 | 糖(需发酵) | 混合菌群(陶厄氏菌、固氮弓菌属) | PHBV | 0.70Cmol /Cmol | 57.50% | 0.76Cmol /Cmol | 0.65~0.71Cmol /Cmol | [ |
含糖废水 | 葡萄糖(需发酵) | 混合菌群(肠杆菌、假单胞菌) | PHBV | — | 56.00% | 5.20g/L | — | [ |
工业糖果发酵废水 | 糖(需发酵) | 混合菌群 (变形球菌) | 3HB | — | 59.10%±0.60% | 0.93Cmol /Cmol | — | [ |
工业糖果发酵废水 | 糖(需发酵) | 混合菌群(酸性 假单胞菌、球菌) | PHB、PHV | 0.64gCOD /gCOD | 70.00% | 0.37g/g | — | [ |
热水解杨树 | 木质素(需发酵) | 混合菌群 (球菌、芽孢杆菌) | PHBV | 530.30mg/g | — | 637.56mg/L | 375.04mg/g | [ |
碱性发酵pH10 条件下发酵污泥 | 蛋白质、脂肪、 多糖(需发酵) | 混合菌群 (未明确组成) | PHB(98.30% )、PHV(1.70%) | 61.80% | 60.30% | — | — | [ |
剩余活性污泥 | 蛋白质、脂肪、 多糖(需发酵) | 混合菌群 (未明确组成) | PHB、PHV | — | 51.00% | — | 0.52Cmol/Cmol | [ |
剩余活性污泥 | 蛋白质、脂肪、 多糖(需发酵) | 混合菌群(副球 菌属、潜水杆菌属、 微小菌属) | PHB、PHV | — | 42.84% | — | — | [ |
剩余活性污泥 | 蛋白质、脂肪、 多糖(需发酵) | 混合菌群(代尔夫特菌属、赖氨酸芽胞杆菌、短波单孢杆菌) | 3HB、3HV、 3H2MV | 35.17% | 42.34% | 1.30g/L | — | [ |
纸浆工业副产品(硬木亚硫酸盐废液物) | 木糖、乙酸 (直接利用) | 混合菌群(ɑ-变形 菌门、β-变形菌门、γ-变形菌门) | P(3HB) | — | 67.60% | 0.77g/g | — | [ |
工业废鱼油 | 油酸、亚油酸 (直接利用) | 混合菌群 (未明确组成) | PHB | — | 82.30% | 0.80Cmmol /Cmmol | — | [ |
粗甘油 | 甘油、游离脂肪酸、脂肪酸甲酯 (直接利用) | 混合菌群 (未明确组成) | PHB | — | 59.00% | 0.44g/g | — | [ |
粗甘油 | 甘油、游离脂肪酸、脂肪酸甲酯 (直接利用) | 混合菌群 | HB、HV | — | 27.02% | — | 1.75gCOD/gCOD | [ |
粗甘油 | 甘油、游离脂肪酸、脂肪酸甲酯 (直接利用) | 混合菌群(黄杆菌属、红球菌属、副球菌属) | HB、HV、HP | — | — | 0.42Cmol /Cmol | 0.24Cmol/Cmol | [ |
粗甘油 | 甘油(直接利用) | 混合菌群(硫杆菌属、副球菌属、索氏菌属) | PHB | — | 27.00% | — | 1.75mg/mg | [ |
粗甘油 | 甘油(直接利用) | 混合菌群 (未明确组成) | PHB | — | 21.80% | 373.70mg/L | 0.22g/g | [ |
甲烷 | 甲烷(直接利用) | 混合菌群 (甲基胞囊菌属) | PHB | — | 34.60%±2.50% | — | — | [ |
甲烷 | 甲烷(直接利用) | 混合菌群 (甲基胞囊菌属) | P3HB | — | 32.00% | — | — | [ |
甲烷 | 甲烷(直接利用) | 混合菌群(甲基囊菌) | PHB | — | 35.10%±0.40% | — | 0.22g/g | [ |
甲烷 | 甲烷(直接利用) | 混合菌群(甲基囊 孢菌、甲基杆菌) | PHB | — | 12.60% | — | — | [ |
甲烷 | 甲烷(直接利用) | 混合菌群(甲基杆菌、甲基单胞菌) | PHB | — | 44.00% | — | — | [ |
甲烷 | 甲烷(直接利用) | 混合菌群(甲基孢囊菌属、甲基杆菌属) | PHB | — | 13.60%±5.60% | — | — | [ |
表2 混合菌群利用废弃有机物合成PHA的研究
底物类型 | 有效底物组分 | 产PHA优势菌 | 合成PHA类型 | 底物转化 效率 | 最大PHA 合成能力 | PHA产量 | PHA转化率 | 参考文献 |
---|---|---|---|---|---|---|---|---|
废弃奶牛粪便 | 蛋白质、糖、 脂肪、粗纤维 (需发酵) | 混合菌群 (甲基杆菌科属、 动胶菌属) | PHB、PHV | — | 90.70% | — | 1.12Cmmol /Cmmol | [ |
废弃奶酪乳清 | 乳糖、脂肪、 蛋白质(需发酵) | 混合菌群 (未明确组成) | HB(70.00%)、HV(30.00%) | — | 60.00% | 7.80g/L | — | [ |
废弃奶酪乳清 | 乳糖、脂肪、 蛋白质(需发酵) | 混合菌群 (未明确组成) | HB(89.00%)、HV(11.00%) | 0.72gCOD /gCOD | 43.00% | — | 0.85Cmol/Cmol | [ |
废弃奶酪乳清 | 乳糖、脂肪、 蛋白质(需发酵) | 混合菌群 (未明确组成) | HB(60.00%)、HV(40.00%) | 0.60Cmmol /Cmmol | 81.40%±0.57% | 0.42mgCOD /mgCOD | 0.80Cmmol /Cmmol | [ |
废弃奶酪乳清 | 乳糖、脂肪、 蛋白质(需发酵) | 混合菌群 (钩虫贪铜菌) | 3HB(94.00%)、HV(6.00%) | 0.85g/g | 71.00% | — | 0.60g/g | [ |
废弃糖蜜 | 糖(需发酵) | 混合菌群(陶厄氏菌、固氮弓菌属) | PHBV | 0.70Cmol /Cmol | 57.50% | 0.76Cmol /Cmol | 0.65~0.71Cmol /Cmol | [ |
含糖废水 | 葡萄糖(需发酵) | 混合菌群(肠杆菌、假单胞菌) | PHBV | — | 56.00% | 5.20g/L | — | [ |
工业糖果发酵废水 | 糖(需发酵) | 混合菌群 (变形球菌) | 3HB | — | 59.10%±0.60% | 0.93Cmol /Cmol | — | [ |
工业糖果发酵废水 | 糖(需发酵) | 混合菌群(酸性 假单胞菌、球菌) | PHB、PHV | 0.64gCOD /gCOD | 70.00% | 0.37g/g | — | [ |
热水解杨树 | 木质素(需发酵) | 混合菌群 (球菌、芽孢杆菌) | PHBV | 530.30mg/g | — | 637.56mg/L | 375.04mg/g | [ |
碱性发酵pH10 条件下发酵污泥 | 蛋白质、脂肪、 多糖(需发酵) | 混合菌群 (未明确组成) | PHB(98.30% )、PHV(1.70%) | 61.80% | 60.30% | — | — | [ |
剩余活性污泥 | 蛋白质、脂肪、 多糖(需发酵) | 混合菌群 (未明确组成) | PHB、PHV | — | 51.00% | — | 0.52Cmol/Cmol | [ |
剩余活性污泥 | 蛋白质、脂肪、 多糖(需发酵) | 混合菌群(副球 菌属、潜水杆菌属、 微小菌属) | PHB、PHV | — | 42.84% | — | — | [ |
剩余活性污泥 | 蛋白质、脂肪、 多糖(需发酵) | 混合菌群(代尔夫特菌属、赖氨酸芽胞杆菌、短波单孢杆菌) | 3HB、3HV、 3H2MV | 35.17% | 42.34% | 1.30g/L | — | [ |
纸浆工业副产品(硬木亚硫酸盐废液物) | 木糖、乙酸 (直接利用) | 混合菌群(ɑ-变形 菌门、β-变形菌门、γ-变形菌门) | P(3HB) | — | 67.60% | 0.77g/g | — | [ |
工业废鱼油 | 油酸、亚油酸 (直接利用) | 混合菌群 (未明确组成) | PHB | — | 82.30% | 0.80Cmmol /Cmmol | — | [ |
粗甘油 | 甘油、游离脂肪酸、脂肪酸甲酯 (直接利用) | 混合菌群 (未明确组成) | PHB | — | 59.00% | 0.44g/g | — | [ |
粗甘油 | 甘油、游离脂肪酸、脂肪酸甲酯 (直接利用) | 混合菌群 | HB、HV | — | 27.02% | — | 1.75gCOD/gCOD | [ |
粗甘油 | 甘油、游离脂肪酸、脂肪酸甲酯 (直接利用) | 混合菌群(黄杆菌属、红球菌属、副球菌属) | HB、HV、HP | — | — | 0.42Cmol /Cmol | 0.24Cmol/Cmol | [ |
粗甘油 | 甘油(直接利用) | 混合菌群(硫杆菌属、副球菌属、索氏菌属) | PHB | — | 27.00% | — | 1.75mg/mg | [ |
粗甘油 | 甘油(直接利用) | 混合菌群 (未明确组成) | PHB | — | 21.80% | 373.70mg/L | 0.22g/g | [ |
甲烷 | 甲烷(直接利用) | 混合菌群 (甲基胞囊菌属) | PHB | — | 34.60%±2.50% | — | — | [ |
甲烷 | 甲烷(直接利用) | 混合菌群 (甲基胞囊菌属) | P3HB | — | 32.00% | — | — | [ |
甲烷 | 甲烷(直接利用) | 混合菌群(甲基囊菌) | PHB | — | 35.10%±0.40% | — | 0.22g/g | [ |
甲烷 | 甲烷(直接利用) | 混合菌群(甲基囊 孢菌、甲基杆菌) | PHB | — | 12.60% | — | — | [ |
甲烷 | 甲烷(直接利用) | 混合菌群(甲基杆菌、甲基单胞菌) | PHB | — | 44.00% | — | — | [ |
甲烷 | 甲烷(直接利用) | 混合菌群(甲基孢囊菌属、甲基杆菌属) | PHB | — | 13.60%±5.60% | — | — | [ |
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