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微波辅助合成5-[4-(4-溴代丁氧基)苯基]-10,15,20-三对甲氧基苯基卟啉

孙福强1,2,梅文杰2,崔英德3   

  1. 1广东工业大学轻工化工学院,广东 广州 510090,2广东药学院药科学院,广东 广州 510006,3广州科技职业技术学院,广东 广州 510550
  • 出版日期:2014-05-05 发布日期:2014-05-05

Microwave-assisted synthesis of 5-[4-(4-bromobutoxy)phenyl]-10,15,20-tri-methoxyphenyporphyrin

SUN Fuqiang1,2,MEI Wenjie2,CUI Yingde3   

  1. 1 Faculty of Chemical Engineering and Light Industry,Guangdong University of Technology,Guangzhou 510090,Guangdong,China;2 School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,Guangdong,China;3 Guangzhou Vocational College of Science and Technology,Guangzhou 510550,Guangdong,China
  • Online:2014-05-05 Published:2014-05-05

摘要: 探讨采用微波辅助合成尾式卟啉(p-BrTMOPP)的制备工艺及其影响因素。以吡咯、对羟基苯甲醛和对甲氧基苯甲醛为原料,以丙酸为溶剂,制备得到p-HTMOPP;以1,4-二溴丁烷为原料,微波辅助加热条件下制备得到目标化合物尾式卟啉p-BrTMOPP;目标产物经过UV-vis、IR、ESI-MS等方法表征。在90℃、DMF溶剂条件下微波辐射加热30min,快速高效得到目标化合物,反应产率89.2%。和传统加热方法相比较,微波辅助合成尾式卟啉化合物明显缩短了反应时间,提高了反应效率。

关键词: 尾式卟啉, 微波辅助合成, 表征

Abstract: The synthesis of a novel tailed porphyrin(p-BrTMOPP) is studied. The p-HTMOPP was prepared from pyrrole,p-hydroxybenzaldehyde and p-methoxybenzaldehyde in propionic acid solution,and then p-HTMOPP and 1,4-dibromobutane were mixed in DMF solution to synthetize p-BrTMOPP by using microwave-assisted synthesis technology. The target compound, p-BrTMOPP, was characterized by using UV-vis, IR,and ESI-MS spectra. The p-BrTMOPP was prepared from p-HTMOPP and 1,4-dibromobutane in DMF solution at 90℃for 30 min under microwave-assisted with a yield of 89.2%. A tailed porphyrin was synthesized under microwave-assisted,and with less time and higher efficiency compared with the conventional method.

Key words: tailed porphyrin, microwave-assisted synthesis, characterization

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