关键词: 膜生物反应器, 膜污染, 生物膜, 群体感应, N-乙酰高丝氨酸环内酯

Abstract: This review described the mechanism of N-acyl homoserine lactone (AHL) style quorum sensing (QS) signal molecules for microorganisms to biofilm formation on the surface of membrane in membrane bioreactors (MBRs). Through the cell-cell communication between microorganisms，the QS determines biofilm formation and secretion of extracellular polymeric substances (EPS). The article summarized studies on the inhibition or disruption of AHL-QS signaling molecules by AHL-acylase or quorum quenching and effectively controlled membrane biofouling. The signaling molecules reduction would weaken biofilm formation ability but enhance membrane filterability. Moreover，the paper reviewed new immobilized methods about the AHL-acylase or quorum quenching，such as immobilized magnetic carriers，membrane surface，microbial-vessel and cell entrapping beads. The QS control strategies offered a promising control alternative but more investigations on the application to real MBRs were needed. Future studies should specifically address the relationship between the QS and microbial metabolism，as well as signaling molecules recognition in real MBR system.

Key words: membrane bioreactors(MBRs), membrane fouling, biofilm, quorum sensing(QS), N-acyl homoserine lactone(AHL)