化工进展 ›› 2023, Vol. 42 ›› Issue (1): 469-479.DOI: 10.16085/j.issn.1000-6613.2022-0570
菌藻共生系统削减抗生素类污染物的去除途径及胁迫响应
应璐瑶(
), 王荣昌()
- 同济大学环境科学与工程学院 长江水环境教育部重点实验室，上海 200092
-
收稿日期:2022-04-06修回日期:2022-05-27出版日期:2023-01-25发布日期:2023-02-20 -
通讯作者:王荣昌 -
作者简介:应璐瑶（1998—），女，硕士研究生，研究方向为菌藻生物膜去除抗生素。E-mail：yingluyao@tongji.edu.cn。 -
基金资助:国家自然科学基金(51878466)
Removal pathways of antibiotic pollutants by bacterial-algal consortium and its stress response mechanisms
YING Luyao(), WANG Rongchang()
- Key Laboratory of Yangtze Aquatic Environment, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China
-
Received:2022-04-06Revised:2022-05-27Online:2023-01-25Published:2023-02-20 -
Contact:WANG Rongchang
摘要：
菌藻共生系统不仅能够高效去除污水中的氮磷、重金属、抗生素等污染物，而且还能够捕集并固定二氧化碳，因而受到日益广泛的关注。本文介绍了菌藻共生系统对抗生素类污染物的去除途径，包括生物降解、生物吸附、生物累积等，其中生物降解是菌藻共生系统去除抗生素的最主要途径；同时简述了降解抗生素的生物反应器类型，主要可分为悬浮生长系统和固定化生长系统。本文还重点介绍了菌藻共生系统应对抗生素胁迫的短期和长期响应机制，短期响应主要是通过产生活性氧（ROS）并激活SOS响应，长期响应则具体表现在抗生素抗性基因的富集转移和微生物群落的演替进化等方面。本文为菌藻共生系统用于去除废水中抗生素类污染物提供了理论依据和技术参考。
中图分类号:
引用本文
应璐瑶, 王荣昌. 菌藻共生系统削减抗生素类污染物的去除途径及胁迫响应[J]. 化工进展, 2023, 42(1): 469-479.
YING Luyao, WANG Rongchang. Removal pathways of antibiotic pollutants by bacterial-algal consortium and its stress response mechanisms[J]. Chemical Industry and Engineering Progress, 2023, 42(1): 469-479.
图1 菌藻共生系统去除抗生素的途径及机制
图1 菌藻共生系统去除抗生素的途径及机制
表1 降解抗生素的生物反应器类型及其去除效果
| 反应器类型 | 生物类型 | 反应器形式 | 地区 | 抗生素类型 | 抗生素浓度 | 去除率 | 参考文献 |
|---|---|---|---|---|---|---|---|
| 悬浮 | 活性污泥 | 序批式反应器（SBR） | 西班牙 | 磺胺甲𫫇唑（SMX） | 50μg/L | 20%～50% | [ |
| 悬浮 | 活性污泥 | 序批式反应器（SBR） | 西班牙 | 磺胺甲𫫇唑（SMX） | 10μg/L、100μg/L | 86%～98% | [ |
| 悬浮 | 活性污泥 | 序批式反应器（SBR） | 台湾（中国） | 磺胺二甲氧嘧啶（SDM） | 100μg/L | >90% | [ |
| 磺胺间甲氧嘧啶（SMM） | 100μg/L | ||||||
| 磺胺甲𫫇唑（SMX） | 100μg/L | ||||||
| 悬浮 | 活性污泥 | 传统膜生物反应器 （MBR） | 嘉兴（中国） | 11种（四环素、磺胺、喹诺酮和大环内酯） | 50mg/L | 25.5%～83.8% | [ |
| 悬浮 | 活性污泥 | 序批式膜生物反应器（SMBR） | 北京（中国） | 磺胺类 | 50μg/L | >90% | [ |
| 四环素类 | 50μg/L | >90% | |||||
| 喹诺酮类 | 50μg/L | <70% | |||||
| 悬浮 | 活性污泥 | 缺氧/好氧膜生物反应器 （A/O-MBR） | 曲阳污水处理厂（中国上海） | 四环素（TC） | 500μg/L | 83.6%～93.6% | [ |
| 土霉素（OTC） | 79.7%～88.6% | ||||||
| 金霉素（CTC） | 77.6%～82.9% | ||||||
| 磺胺甲𫫇唑（SMX） | 88.5%～99.5% | ||||||
| 磺胺嘧啶（SDZ） | 93.8%～99.7% | ||||||
| 氨苄青霉素（AMP） | 94.4%～99.9% | ||||||
| 悬浮 | 小球藻 （Chlorella sp.） | 透明生物反应器 | — | 头孢氨苄（CFX） | 500mg/L | 71.2%～82.8% | [ |
| 悬浮 | 衣藻 （Chlamydomonas sp.） | 光生物反应器 | 台湾（中国） | 环丙沙星（CIP） | 1mg/L、5mg/L、10mg/L | >99% | [ |
| 磺胺嘧啶（SDZ） | 50% | ||||||
| 悬浮 | 雨生红球藻 （Haematococcus pluvialis)-活性污泥 | 传统膜生物反应器（MBR） | — | 抗生素磺胺甲𫫇唑（SMX） | 100mg/L | 94.42%～97.08% | [ |
| 四环素（TET） | 37.3mg/L | 69.75%～89.73% | |||||
| 红霉素（ERY） | 100mg/L | 94.41%～98.15% | |||||
| 悬浮 | 蛋白核小球藻 （Chlorella pyrenoidosa）- 活性污泥 | 透明生物反应器 | 南京（中国） | 头孢拉定 | 100mg/L | 94% | [ |
| 头孢氨苄 | 94% | ||||||
| 头孢他啶 | 94.80% | ||||||
| 头孢克肟 | 91.10% | ||||||
| 悬浮 | 细菌-微藻 （Chlorella sp.） | 搅拌罐光生物反应器（STPBR） | 埃及 | 扑热息痛 | 0.25mg/L、0.5mg/L | 95%～98% | [ |
| 酮洛芬 | |||||||
| 阿司匹林 | |||||||
| 固定化 | 活性污泥 | 生物膜膜生物反应器（BF-MBR） | 嘉兴（中国） | 11种（四环素、磺胺、喹诺酮和大环内酯） | 50mg/L | 45.3%～86.8% | [ |
| 固定化 | 活性污泥 | 厌氧/好氧移动床生物膜反应器（A/O-MBBR） | — | 四环素（TC） | 50μg/L、100μg/L、150μg/L、200μg/L | >42% | [ |
| 固定化 | 活性污泥 | 膜曝气生物膜反应器（MABR） | — | 氯四环素（CTC） | 0.4mg/L、0.1mg/L、0.05mg/L | 12.32%～68.91% | [ |
| 固定化 | 布朗葡萄藻 （Botryococcus braunii） | 淹没式膜生物反应器（SMPBR） | 韩国 | 磺胺甲嘧啶（SMZ） | 47.6～85.7mg/L | 53%～98% | [ |
| 磺胺噻唑（STZ） | |||||||
| 磺胺甲𫫇唑（SMX） | |||||||
| 固定化 | 小球藻 （Chlorellavulgaris） | 生物膜光生物反应器（BF-MPBR） | 舟山（中国） | 磺胺嘧啶（SDZ） | (0.12±0.02)mg/L | 61.0%～79.2% | [ |
| 磺胺甲嘧啶（SMZ） | (0.046±0.04)mg/L | 50.0%～76.7% | |||||
| 磺胺甲𫫇唑（SMX） | (0.14±0.01)mg/L | 60.8%～82.1% | |||||
| 固定化 | 细菌-铜绿藻 （Microcystisaeruginosa） | 人工控制的城市河流（ACUR） | 上海（中国） | 阿奇霉素（AZM） | 均为相对浓度 | 88%～90% | [ |
| 克拉霉素（CLM） | 87%～97% | ||||||
| 磺胺噻唑（STZ） | 76%～81% | ||||||
| 磺胺甲𫫇唑（SMX） | 73%～79% | ||||||
| 环丙沙星（CIP） | 76%～86% | ||||||
| 四环素（TC） | 75%～85% |
表1 降解抗生素的生物反应器类型及其去除效果
| 反应器类型 | 生物类型 | 反应器形式 | 地区 | 抗生素类型 | 抗生素浓度 | 去除率 | 参考文献 |
|---|---|---|---|---|---|---|---|
| 悬浮 | 活性污泥 | 序批式反应器（SBR） | 西班牙 | 磺胺甲𫫇唑（SMX） | 50μg/L | 20%～50% | [ |
| 悬浮 | 活性污泥 | 序批式反应器（SBR） | 西班牙 | 磺胺甲𫫇唑（SMX） | 10μg/L、100μg/L | 86%～98% | [ |
| 悬浮 | 活性污泥 | 序批式反应器（SBR） | 台湾（中国） | 磺胺二甲氧嘧啶（SDM） | 100μg/L | >90% | [ |
| 磺胺间甲氧嘧啶（SMM） | 100μg/L | ||||||
| 磺胺甲𫫇唑（SMX） | 100μg/L | ||||||
| 悬浮 | 活性污泥 | 传统膜生物反应器 （MBR） | 嘉兴（中国） | 11种（四环素、磺胺、喹诺酮和大环内酯） | 50mg/L | 25.5%～83.8% | [ |
| 悬浮 | 活性污泥 | 序批式膜生物反应器（SMBR） | 北京（中国） | 磺胺类 | 50μg/L | >90% | [ |
| 四环素类 | 50μg/L | >90% | |||||
| 喹诺酮类 | 50μg/L | <70% | |||||
| 悬浮 | 活性污泥 | 缺氧/好氧膜生物反应器 （A/O-MBR） | 曲阳污水处理厂（中国上海） | 四环素（TC） | 500μg/L | 83.6%～93.6% | [ |
| 土霉素（OTC） | 79.7%～88.6% | ||||||
| 金霉素（CTC） | 77.6%～82.9% | ||||||
| 磺胺甲𫫇唑（SMX） | 88.5%～99.5% | ||||||
| 磺胺嘧啶（SDZ） | 93.8%～99.7% | ||||||
| 氨苄青霉素（AMP） | 94.4%～99.9% | ||||||
| 悬浮 | 小球藻 （Chlorella sp.） | 透明生物反应器 | — | 头孢氨苄（CFX） | 500mg/L | 71.2%～82.8% | [ |
| 悬浮 | 衣藻 （Chlamydomonas sp.） | 光生物反应器 | 台湾（中国） | 环丙沙星（CIP） | 1mg/L、5mg/L、10mg/L | >99% | [ |
| 磺胺嘧啶（SDZ） | 50% | ||||||
| 悬浮 | 雨生红球藻 （Haematococcus pluvialis)-活性污泥 | 传统膜生物反应器（MBR） | — | 抗生素磺胺甲𫫇唑（SMX） | 100mg/L | 94.42%～97.08% | [ |
| 四环素（TET） | 37.3mg/L | 69.75%～89.73% | |||||
| 红霉素（ERY） | 100mg/L | 94.41%～98.15% | |||||
| 悬浮 | 蛋白核小球藻 （Chlorella pyrenoidosa）- 活性污泥 | 透明生物反应器 | 南京（中国） | 头孢拉定 | 100mg/L | 94% | [ |
| 头孢氨苄 | 94% | ||||||
| 头孢他啶 | 94.80% | ||||||
| 头孢克肟 | 91.10% | ||||||
| 悬浮 | 细菌-微藻 （Chlorella sp.） | 搅拌罐光生物反应器（STPBR） | 埃及 | 扑热息痛 | 0.25mg/L、0.5mg/L | 95%～98% | [ |
| 酮洛芬 | |||||||
| 阿司匹林 | |||||||
| 固定化 | 活性污泥 | 生物膜膜生物反应器（BF-MBR） | 嘉兴（中国） | 11种（四环素、磺胺、喹诺酮和大环内酯） | 50mg/L | 45.3%～86.8% | [ |
| 固定化 | 活性污泥 | 厌氧/好氧移动床生物膜反应器（A/O-MBBR） | — | 四环素（TC） | 50μg/L、100μg/L、150μg/L、200μg/L | >42% | [ |
| 固定化 | 活性污泥 | 膜曝气生物膜反应器（MABR） | — | 氯四环素（CTC） | 0.4mg/L、0.1mg/L、0.05mg/L | 12.32%～68.91% | [ |
| 固定化 | 布朗葡萄藻 （Botryococcus braunii） | 淹没式膜生物反应器（SMPBR） | 韩国 | 磺胺甲嘧啶（SMZ） | 47.6～85.7mg/L | 53%～98% | [ |
| 磺胺噻唑（STZ） | |||||||
| 磺胺甲𫫇唑（SMX） | |||||||
| 固定化 | 小球藻 （Chlorellavulgaris） | 生物膜光生物反应器（BF-MPBR） | 舟山（中国） | 磺胺嘧啶（SDZ） | (0.12±0.02)mg/L | 61.0%～79.2% | [ |
| 磺胺甲嘧啶（SMZ） | (0.046±0.04)mg/L | 50.0%～76.7% | |||||
| 磺胺甲𫫇唑（SMX） | (0.14±0.01)mg/L | 60.8%～82.1% | |||||
| 固定化 | 细菌-铜绿藻 （Microcystisaeruginosa） | 人工控制的城市河流（ACUR） | 上海（中国） | 阿奇霉素（AZM） | 均为相对浓度 | 88%～90% | [ |
| 克拉霉素（CLM） | 87%～97% | ||||||
| 磺胺噻唑（STZ） | 76%～81% | ||||||
| 磺胺甲𫫇唑（SMX） | 73%～79% | ||||||
| 环丙沙星（CIP） | 76%～86% | ||||||
| 四环素（TC） | 75%～85% |
图2 菌藻共生系统应对抗生素胁迫的响应机制
图2 菌藻共生系统应对抗生素胁迫的响应机制
图3 菌藻共生系统中抗生素抗性基因水平转移机制示意图
图3 菌藻共生系统中抗生素抗性基因水平转移机制示意图
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