化工进展 ›› 2019, Vol. 38 ›› Issue (06): 2905-2914.DOI: 10.16085/j.issn.1000-6613.2018-2126
收稿日期:
2018-10-30
出版日期:
2019-06-05
发布日期:
2019-06-05
通讯作者:
孙华
作者简介:
李丽(1992—),女,硕士研究生,研究方向为工业结晶、药物分离与纯化。E-mail:<email>lili_L0815@163.com</email>。
Li LI(),Baoshu LIU,Xueming ZHENG,Hua SUN()
Received:
2018-10-30
Online:
2019-06-05
Published:
2019-06-05
Contact:
Hua SUN
摘要:
目前舒巴坦钠粗品的提纯采用还原成舒巴坦酸后再经反应结晶合成舒巴坦钠的方式,耗时耗力且所需药品、试剂种类较多,不节能环保。针对该问题,采用正交实验
中图分类号:
李丽, 刘宝树, 郑学明, 孙华. 舒巴坦钠溶析结晶工艺优化[J]. 化工进展, 2019, 38(06): 2905-2914.
Li LI, Baoshu LIU, Xueming ZHENG, Hua SUN. Optimization of anti-solvent crystallization process of sulbactam sodium[J]. Chemical Industry and Engineering Progress, 2019, 38(06): 2905-2914.
水平 | A 养晶时间 /h | B 溶析剂 用量/mL | C 溶析剂中乙醇的体积分数/% | D 滴加速率 /mL·min-1 | E 搅拌速度 /r·min-1 | F 温度/℃ |
---|---|---|---|---|---|---|
1 | 1 | 300.0 | 0 | 6.0 | 237~253 | 5.0 |
2 | 2 | 375.0 | 50 | 7.5 | 300~330 | 15.0 |
3 | 3 | 450.0 | 100 | 9.0 | 350~380 | 25.0 |
表1 因素与水平表
水平 | A 养晶时间 /h | B 溶析剂 用量/mL | C 溶析剂中乙醇的体积分数/% | D 滴加速率 /mL·min-1 | E 搅拌速度 /r·min-1 | F 温度/℃ |
---|---|---|---|---|---|---|
1 | 1 | 300.0 | 0 | 6.0 | 237~253 | 5.0 |
2 | 2 | 375.0 | 50 | 7.5 | 300~330 | 15.0 |
3 | 3 | 450.0 | 100 | 9.0 | 350~380 | 25.0 |
序号 | A | B | A×B | A×B | C | A×C | A×C | B×C | D | 空白 | B×C | E | F | D[4,3]/μm | x/% | 综合评分 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 77.50 | 99.1576 | 76.74 |
2 | 1 | 1 | 1 | 1` | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 125.00 | 95.3440 | 78.18 |
3 | 1 | 1 | 1 | 1 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 21.70 | 97.1945 | 70.50 |
4 | 1 | 2 | 2 | 2 | 1 | 1 | 1 | 2 | 2 | 2 | 3 | 3 | 3 | 145.00 | 99.0681 | 82.55 |
5 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 3 | 3 | 3 | 1 | 1 | 1 | 135.00 | 94.0519 | 78.13 |
6 | 1 | 2 | 2 | 2 | 3 | 3 | 3 | 1 | 1 | 1 | 2 | 2 | 2 | 158.00 | 93.9219 | 80.04 |
7 | 1 | 3 | 3 | 3 | 1 | 1 | 1 | 3 | 3 | 3 | 2 | 2 | 2 | 141.00 | 98.6865 | 81.93 |
8 | 1 | 3 | 3 | 3 | 2 | 2 | 2 | 1 | 1 | 1 | 3 | 3 | 3 | 183.00 | 96.4820 | 84.02 |
9 | 1 | 3 | 3 | 3 | 3 | 3 | 3 | 2 | 2 | 2 | 1 | 1 | 1 | 174.00 | 94.6185 | 81.93 |
10 | 2 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 178.00 | 94.3386 | 82.08 |
11 | 2 | 1 | 2 | 3 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 114.00 | 99.1497 | 79.91 |
12 | 2 | 1 | 2 | 3 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 64.90 | 96.1809 | 73.54 |
13 | 2 | 2 | 3 | 1 | 1 | 2 | 3 | 2 | 3 | 1 | 3 | 1 | 2 | 345.00 | 98.8351 | 99.77 |
14 | 2 | 2 | 3 | 1 | 2 | 3 | 1 | 3 | 1 | 2 | 1 | 2 | 3 | 142.00 | 96.2244 | 80.28 |
15 | 2 | 2 | 3 | 1 | 3 | 1 | 2 | 1 | 2 | 3 | 2 | 3 | 1 | 138.00 | 96.5311 | 80.15 |
16 | 2 | 3 | 1 | 2 | 1 | 2 | 3 | 3 | 1 | 2 | 2 | 3 | 1 | 205.00 | 98.9170 | 87.66 |
17 | 2 | 3 | 1 | 2 | 2 | 3 | 1 | 1 | 2 | 3 | 3 | 1 | 2 | 181.00 | 94.5988 | 82.52 |
18 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 2 | 3 | 1 | 1 | 2 | 3 | 140.00 | 97.5186 | 81.02 |
19 | 3 | 1 | 3 | 2 | 1 | 3 | 2 | 1 | 3 | 2 | 1 | 3 | 2 | 164.00 | 99.0285 | 84.17 |
20 | 3 | 1 | 3 | 2 | 2 | 1 | 3 | 2 | 1 | 3 | 2 | 1 | 3 | 95.40 | 95.7996 | 75.93 |
21 | 3 | 1 | 3 | 2 | 3 | 2 | 1 | 3 | 2 | 1 | 3 | 2 | 1 | 147.00 | 94.7566 | 79.68 |
22 | 3 | 2 | 1 | 3 | 1 | 3 | 2 | 2 | 1 | 3 | 3 | 2 | 1 | 159.00 | 98.9166 | 83.66 |
23 | 3 | 2 | 1 | 3 | 2 | 1 | 3 | 3 | 2 | 1 | 1 | 3 | 2 | 218.00 | 94.5893 | 85.73 |
24 | 3 | 2 | 1 | 3 | 3 | 2 | 1 | 1 | 3 | 2 | 2 | 1 | 3 | 125.00 | 97.4810 | 79.69 |
25 | 3 | 3 | 2 | 1 | 1 | 3 | 2 | 3 | 2 | 1 | 2 | 1 | 3 | 185.00 | 94.2366 | 82.61 |
26 | 3 | 3 | 2 | 1 | 2 | 1 | 3 | 1 | 3 | 2 | 3 | 2 | 1 | 216.00 | 93.9306 | 85.09 |
27 | 3 | 3 | 2 | 1 | 3 | 2 | 1 | 2 | 1 | 3 | 1 | 3 | 2 | 110.00 | 97.5640 | 78.44 |
表2 设计及实验结果
序号 | A | B | A×B | A×B | C | A×C | A×C | B×C | D | 空白 | B×C | E | F | D[4,3]/μm | x/% | 综合评分 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 77.50 | 99.1576 | 76.74 |
2 | 1 | 1 | 1 | 1` | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 125.00 | 95.3440 | 78.18 |
3 | 1 | 1 | 1 | 1 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 21.70 | 97.1945 | 70.50 |
4 | 1 | 2 | 2 | 2 | 1 | 1 | 1 | 2 | 2 | 2 | 3 | 3 | 3 | 145.00 | 99.0681 | 82.55 |
5 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 3 | 3 | 3 | 1 | 1 | 1 | 135.00 | 94.0519 | 78.13 |
6 | 1 | 2 | 2 | 2 | 3 | 3 | 3 | 1 | 1 | 1 | 2 | 2 | 2 | 158.00 | 93.9219 | 80.04 |
7 | 1 | 3 | 3 | 3 | 1 | 1 | 1 | 3 | 3 | 3 | 2 | 2 | 2 | 141.00 | 98.6865 | 81.93 |
8 | 1 | 3 | 3 | 3 | 2 | 2 | 2 | 1 | 1 | 1 | 3 | 3 | 3 | 183.00 | 96.4820 | 84.02 |
9 | 1 | 3 | 3 | 3 | 3 | 3 | 3 | 2 | 2 | 2 | 1 | 1 | 1 | 174.00 | 94.6185 | 81.93 |
10 | 2 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 178.00 | 94.3386 | 82.08 |
11 | 2 | 1 | 2 | 3 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 114.00 | 99.1497 | 79.91 |
12 | 2 | 1 | 2 | 3 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 64.90 | 96.1809 | 73.54 |
13 | 2 | 2 | 3 | 1 | 1 | 2 | 3 | 2 | 3 | 1 | 3 | 1 | 2 | 345.00 | 98.8351 | 99.77 |
14 | 2 | 2 | 3 | 1 | 2 | 3 | 1 | 3 | 1 | 2 | 1 | 2 | 3 | 142.00 | 96.2244 | 80.28 |
15 | 2 | 2 | 3 | 1 | 3 | 1 | 2 | 1 | 2 | 3 | 2 | 3 | 1 | 138.00 | 96.5311 | 80.15 |
16 | 2 | 3 | 1 | 2 | 1 | 2 | 3 | 3 | 1 | 2 | 2 | 3 | 1 | 205.00 | 98.9170 | 87.66 |
17 | 2 | 3 | 1 | 2 | 2 | 3 | 1 | 1 | 2 | 3 | 3 | 1 | 2 | 181.00 | 94.5988 | 82.52 |
18 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 2 | 3 | 1 | 1 | 2 | 3 | 140.00 | 97.5186 | 81.02 |
19 | 3 | 1 | 3 | 2 | 1 | 3 | 2 | 1 | 3 | 2 | 1 | 3 | 2 | 164.00 | 99.0285 | 84.17 |
20 | 3 | 1 | 3 | 2 | 2 | 1 | 3 | 2 | 1 | 3 | 2 | 1 | 3 | 95.40 | 95.7996 | 75.93 |
21 | 3 | 1 | 3 | 2 | 3 | 2 | 1 | 3 | 2 | 1 | 3 | 2 | 1 | 147.00 | 94.7566 | 79.68 |
22 | 3 | 2 | 1 | 3 | 1 | 3 | 2 | 2 | 1 | 3 | 3 | 2 | 1 | 159.00 | 98.9166 | 83.66 |
23 | 3 | 2 | 1 | 3 | 2 | 1 | 3 | 3 | 2 | 1 | 1 | 3 | 2 | 218.00 | 94.5893 | 85.73 |
24 | 3 | 2 | 1 | 3 | 3 | 2 | 1 | 1 | 3 | 2 | 2 | 1 | 3 | 125.00 | 97.4810 | 79.69 |
25 | 3 | 3 | 2 | 1 | 1 | 3 | 2 | 3 | 2 | 1 | 2 | 1 | 3 | 185.00 | 94.2366 | 82.61 |
26 | 3 | 3 | 2 | 1 | 2 | 1 | 3 | 1 | 3 | 2 | 3 | 2 | 1 | 216.00 | 93.9306 | 85.09 |
27 | 3 | 3 | 2 | 1 | 3 | 2 | 1 | 2 | 1 | 3 | 1 | 3 | 2 | 110.00 | 97.5640 | 78.44 |
因素 | | | | |
---|---|---|---|---|
A | 128.91 | 167.54 | 157.711 | 7256.007 |
B | 109.72 | 173.89 | 170.556 | 23487.500 |
A×B | 139.13 | 145.100 | 169.93 | 4802.807 |
A×B | 151.133 | 152.27 | 150.77 | 11.007 |
C | 177.72 | 156.600 | 119.844 | 15440.869 |
A×C | 137.311 | 172.556 | 144.300 | 6268.176 |
A×C | 131.39 | 143.767 | 179.011 | 10989.769 |
B×C | 157.833 | 156.378 | 139.96 | 1774.269 |
D | 132.756 | 165.667 | 155.744 | 5130.242 |
空白 | 174.167 | 151.211 | 128.79 | 9266.569 |
B×C | 148.722 | 142.93 | 162.511 | 1820.802 |
E | 153.644 | 156.222 | 144.300 | 708.309 |
F | 151.722 | 167.43 | 135.011 | 4731.902 |
表3 粒度D[4,3]的实验结果计算表[33]
因素 | | | | |
---|---|---|---|---|
A | 128.91 | 167.54 | 157.711 | 7256.007 |
B | 109.72 | 173.89 | 170.556 | 23487.500 |
A×B | 139.13 | 145.100 | 169.93 | 4802.807 |
A×B | 151.133 | 152.27 | 150.77 | 11.007 |
C | 177.72 | 156.600 | 119.844 | 15440.869 |
A×C | 137.311 | 172.556 | 144.300 | 6268.176 |
A×C | 131.39 | 143.767 | 179.011 | 10989.769 |
B×C | 157.833 | 156.378 | 139.96 | 1774.269 |
D | 132.756 | 165.667 | 155.744 | 5130.242 |
空白 | 174.167 | 151.211 | 128.79 | 9266.569 |
B×C | 148.722 | 142.93 | 162.511 | 1820.802 |
E | 153.644 | 156.222 | 144.300 | 708.309 |
F | 151.722 | 167.43 | 135.011 | 4731.902 |
方差来源 | Sj | f | | Fj | F-theory | 显著性 |
---|---|---|---|---|---|---|
A | 7256.007 | 2 | 3628.003 | 1.84 | 2.62-3.54-4.56 | |
B | 23487.500 | 2 | 11743.750 | 5.95 | ** | |
C | 15440.869 | 2 | 7720.434 | 3.91 | * | |
D △ | 5130.242 | 2 | 2565.121 | 1.30 | ||
E △ | 708.309 | 2 | 354.154 | 0.18 | ||
F △ | 4731.902 | 2 | 2365.951 | 1.20 | ||
A×B △ | 4813.813 | 4 | 1203.453 | 0.61 | 2.29-2.93-3.61 | |
A×C | 17257.944 | 4 | 4314.486 | 2.19 | ||
B×C △ | 3595.071 | 4 | 898.768 | 0.46 | ||
e | 9266.569 | 2 | 4633.284 | 2.35 | ||
| 35501.913 | 18 | 1972.329 |
表4 粒度的方差分析
方差来源 | Sj | f | | Fj | F-theory | 显著性 |
---|---|---|---|---|---|---|
A | 7256.007 | 2 | 3628.003 | 1.84 | 2.62-3.54-4.56 | |
B | 23487.500 | 2 | 11743.750 | 5.95 | ** | |
C | 15440.869 | 2 | 7720.434 | 3.91 | * | |
D △ | 5130.242 | 2 | 2565.121 | 1.30 | ||
E △ | 708.309 | 2 | 354.154 | 0.18 | ||
F △ | 4731.902 | 2 | 2365.951 | 1.20 | ||
A×B △ | 4813.813 | 4 | 1203.453 | 0.61 | 2.29-2.93-3.61 | |
A×C | 17257.944 | 4 | 4314.486 | 2.19 | ||
B×C △ | 3595.071 | 4 | 898.768 | 0.46 | ||
e | 9266.569 | 2 | 4633.284 | 2.35 | ||
| 35501.913 | 18 | 1972.329 |
因素 | | | | |
---|---|---|---|---|
A | 96.50 | 96.92 | 96.26 | 2.039 |
B | 96.77 | 96.62 | 96.28 | 1.130 |
A×B | 97.08 | 95.83 | 96.77 | 7.678 |
A×B | 96.56 | 96.41 | 96.72 | 0.430 |
C | 97.91 | 95.57 | 96.20 | 26.319 |
A×C | 96.83 | 96.42 | 96.43 | 0.978 |
A×C | 97.41 | 96.48 | 95.79 | 11.842 |
B×C | 96.16 | 97.42 | 96.09 | 10.094 |
D | 97.02 | 95.34 | 97.32 | 20.426 |
空白 | 96.52 | 96.75 | 96.41 | 0.564 |
B×C | 96.34 | 96.67 | 96.66 | 0.634 |
E | 96.11 | 95.96 | 97.61 | 15.087 |
F | 96.67 | 96.53 | 96.48 | 0.172 |
表5 纯度的实验结果计算表
因素 | | | | |
---|---|---|---|---|
A | 96.50 | 96.92 | 96.26 | 2.039 |
B | 96.77 | 96.62 | 96.28 | 1.130 |
A×B | 97.08 | 95.83 | 96.77 | 7.678 |
A×B | 96.56 | 96.41 | 96.72 | 0.430 |
C | 97.91 | 95.57 | 96.20 | 26.319 |
A×C | 96.83 | 96.42 | 96.43 | 0.978 |
A×C | 97.41 | 96.48 | 95.79 | 11.842 |
B×C | 96.16 | 97.42 | 96.09 | 10.094 |
D | 97.02 | 95.34 | 97.32 | 20.426 |
空白 | 96.52 | 96.75 | 96.41 | 0.564 |
B×C | 96.34 | 96.67 | 96.66 | 0.634 |
E | 96.11 | 95.96 | 97.61 | 15.087 |
F | 96.67 | 96.53 | 96.48 | 0.172 |
方差来源 | S | f | | Fj | F-theory | 显著性 |
---|---|---|---|---|---|---|
A | 2.039 | 2 | 1.019 | 3.28 | 5.14-7.26-10.90 | |
B△ | 1.130 | 2 | 0.565 | |||
C | 26.319 | 2 | 13.160 | 42.32 | ** | |
D | 20.426 | 2 | 10.213 | 32.84 | ** | |
E | 15.087 | 2 | 7.543 | 24.26 | ** | |
F△ | 0.172 | 2 | 0.086 | |||
A×B | 8.108 | 4 | 2.027 | 6.52 | 4.53-6.23-9.15 | * |
A×C | 12.820 | 4 | 3.205 | 10.31 | ** | |
B×C | 10.727 | 4 | 2.682 | 8.62 | * | |
e | 0.546 | 2 | 0.282 | |||
| 1.866 | 6 | 0.311 |
表6 纯度的方差分析表
方差来源 | S | f | | Fj | F-theory | 显著性 |
---|---|---|---|---|---|---|
A | 2.039 | 2 | 1.019 | 3.28 | 5.14-7.26-10.90 | |
B△ | 1.130 | 2 | 0.565 | |||
C | 26.319 | 2 | 13.160 | 42.32 | ** | |
D | 20.426 | 2 | 10.213 | 32.84 | ** | |
E | 15.087 | 2 | 7.543 | 24.26 | ** | |
F△ | 0.172 | 2 | 0.086 | |||
A×B | 8.108 | 4 | 2.027 | 6.52 | 4.53-6.23-9.15 | * |
A×C | 12.820 | 4 | 3.205 | 10.31 | ** | |
B×C | 10.727 | 4 | 2.682 | 8.62 | * | |
e | 0.546 | 2 | 0.282 | |||
| 1.866 | 6 | 0.311 |
项目 | C 1 | C 2 | C 3 | KiA | ai |
---|---|---|---|---|---|
A 1 | D 11=296.91 | D 12=285.88 | D 13=285.73 | 868.53 | -0.06 |
A 2 | D 21=292.09 | D 22=289.97 | D 23=290.23 | 872.29 | 0.36 |
A 3 | D 31=292.18 | D 32=284.32 | D 33=289.80 | 866.30 | -0.30 |
KiC | 881.18 | 860.17 | 865.77 | 2607.12 | |
cj | 1.35 | -0.99 | -0.36 |
表7 因素A,C的二元表
项目 | C 1 | C 2 | C 3 | KiA | ai |
---|---|---|---|---|---|
A 1 | D 11=296.91 | D 12=285.88 | D 13=285.73 | 868.53 | -0.06 |
A 2 | D 21=292.09 | D 22=289.97 | D 23=290.23 | 872.29 | 0.36 |
A 3 | D 31=292.18 | D 32=284.32 | D 33=289.80 | 866.30 | -0.30 |
KiC | 881.18 | 860.17 | 865.77 | 2607.12 | |
cj | 1.35 | -0.99 | -0.36 |
项目 | C 1 | C 2 | C 3 |
---|---|---|---|
A 1 | 1.21 | -0.22 | -0.89 |
A 2 | -0.91 | 0.72 | 0.19 |
A 3 | -0.21 | -0.50 | 0.71 |
表8 纯度的 a c i j 值表
项目 | C 1 | C 2 | C 3 |
---|---|---|---|
A 1 | 1.21 | -0.22 | -0.89 |
A 2 | -0.91 | 0.72 | 0.19 |
A 3 | -0.21 | -0.50 | 0.71 |
项目 | C 1 | C 2 | C 3 | KiB | bi |
---|---|---|---|---|---|
B 1 | 292.52 | 290.29 | 288.13 | 870.95 | 0.21 |
B 2 | 296.82 | 284.87 | 287.93 | 869.62 | 0.06 |
B 3 | 291.84 | 285.01 | 289.70 | 866.55 | -0.28 |
KiC | 881.18 | 860.17 | 865.77 | 2607.12 | |
cj | 1.35 | -0.99 | -0.36 |
表9 因素B,C的二元表
项目 | C 1 | C 2 | C 3 | KiB | bi |
---|---|---|---|---|---|
B 1 | 292.52 | 290.29 | 288.13 | 870.95 | 0.21 |
B 2 | 296.82 | 284.87 | 287.93 | 869.62 | 0.06 |
B 3 | 291.84 | 285.01 | 289.70 | 866.55 | -0.28 |
KiC | 881.18 | 860.17 | 865.77 | 2607.12 | |
cj | 1.35 | -0.99 | -0.36 |
项目 | C 1 | C 2 | C 3 |
---|---|---|---|
B 1 | -0.61 | 0.98 | -0.36 |
B 2 | 0.97 | -0.68 | -0.28 |
B 3 | -0.35 | -0.29 | 0.65 |
表10 B,C交互作用 b c i j 表
项目 | C 1 | C 2 | C 3 |
---|---|---|---|
B 1 | -0.61 | 0.98 | -0.36 |
B 2 | 0.97 | -0.68 | -0.28 |
B 3 | -0.35 | -0.29 | 0.65 |
因素 | | | | |
---|---|---|---|---|
A | 79.34 | 82.99 | 81.67 | 61.63 |
B | 77.86 | 83.33 | 82.80 | 164.14 |
A×B | 80.63 | 80.27 | 83.09 | 42.58 |
A×B | 81.31 | 81.30 | 81.39 | 0.04 |
C | 84.57 | 81.09 | 78.33 | 176.14 |
A×C | 80.30 | 83.07 | 80.62 | 41.40 |
A×C | 80.19 | 80.61 | 83.19 | 47.54 |
B×C | 81.61 | 82.37 | 80.01 | 26.28 |
D | 80.03 | 81.71 | 82.25 | 23.98 |
空白 | 83.28 | 81.45 | 79.26 | 72.98 |
B×C | 80.95 | 80.68 | 82.37 | 14.92 |
E | 81.21 | 81.33 | 81.46 | 0.28 |
F | 81.44 | 82.70 | 79.85 | 36.73 |
表11 综合评分的计算表
因素 | | | | |
---|---|---|---|---|
A | 79.34 | 82.99 | 81.67 | 61.63 |
B | 77.86 | 83.33 | 82.80 | 164.14 |
A×B | 80.63 | 80.27 | 83.09 | 42.58 |
A×B | 81.31 | 81.30 | 81.39 | 0.04 |
C | 84.57 | 81.09 | 78.33 | 176.14 |
A×C | 80.30 | 83.07 | 80.62 | 41.40 |
A×C | 80.19 | 80.61 | 83.19 | 47.54 |
B×C | 81.61 | 82.37 | 80.01 | 26.28 |
D | 80.03 | 81.71 | 82.25 | 23.98 |
空白 | 83.28 | 81.45 | 79.26 | 72.98 |
B×C | 80.95 | 80.68 | 82.37 | 14.92 |
E | 81.21 | 81.33 | 81.46 | 0.28 |
F | 81.44 | 82.70 | 79.85 | 36.73 |
方差来源 | S | f | | F j | F-theory | 显著性 |
---|---|---|---|---|---|---|
A | 61.63 | 2 | 30.82 | 2.62-3.54-4.56 | ||
B | 164.14 | 2 | 82.07 | 5.29 | * | |
C | 176.14 | 2 | 88.07 | 5.67 | * | |
D | 23.98 | 2 | 11.99 | |||
E | 0.28 | 2 | 0.14 | |||
F | 36.73 | 2 | 18.37 | |||
A×B | 42.62 | 4 | 10.65 | 2.29-2.93-3.61 | ||
A×C | 88.94 | 4 | 22.24 | 1.43 | 不显著 | |
B×C | 41.20 | 4 | 10.30 | |||
e | 72.98 | 2 | 36.49 | |||
| 279.43 | 18 | 15.52 |
表12 综合评分的方差分析
方差来源 | S | f | | F j | F-theory | 显著性 |
---|---|---|---|---|---|---|
A | 61.63 | 2 | 30.82 | 2.62-3.54-4.56 | ||
B | 164.14 | 2 | 82.07 | 5.29 | * | |
C | 176.14 | 2 | 88.07 | 5.67 | * | |
D | 23.98 | 2 | 11.99 | |||
E | 0.28 | 2 | 0.14 | |||
F | 36.73 | 2 | 18.37 | |||
A×B | 42.62 | 4 | 10.65 | 2.29-2.93-3.61 | ||
A×C | 88.94 | 4 | 22.24 | 1.43 | 不显著 | |
B×C | 41.20 | 4 | 10.30 | |||
e | 72.98 | 2 | 36.49 | |||
| 279.43 | 18 | 15.52 |
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