化工进展 ›› 2021, Vol. 40 ›› Issue (1): 339-345.DOI: 10.16085/j.issn.1000-6613.2020-0568

• 材料科学与技术 • 上一篇    下一篇

壳聚糖胶囊材料的制备及其缓释性能

刘其海1,2,3(), 谢婉婷1, 贾振宇1,2,3(), 朱小花2, 王荣辉2   

  1. 1.仲恺农业工程学院化学化工学院,广东 广州 510225
    2.湛江博泰生物化工科技实业有限公司,广东 湛江 524051
    3.广东维芊科技有限公司,广东 佛山 528216
  • 收稿日期:2020-04-13 出版日期:2021-01-05 发布日期:2021-01-12
  • 通讯作者: 贾振宇
  • 作者简介:刘其海(1977—),男,副教授,研究领域为生物质及天然高分子转化与应用。E-mail:lqh2003@163.com
  • 基金资助:
    广东省省级科技计划(2016A010105022);广州市科技计划(201704020023);广东省促进经济发展专项(粤自然资源合[2019]016号);湛江市海洋经济创新发展示范市建设项目(湛海创2017C4A);湛江市科技发展专项资金竞争性分配项目(2016A02010);佛山市科技创新项目(2019)

Preparation of chitosan capsule materials and its sustained release properties

Qihai LIU1,2,3(), Wanting XIE1, Zhenyu JIA1,2,3(), Xiaohua ZHU2, Ronghui WANG2   

  1. 1.College of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, Guangdong, China
    2.Zhanjiang Botai Bio-Chemical Technology Industrial Co. , Ltd. , Zhanjiang 524051, Guangdong, China
    3.Guangdong Weiqian Technology Co. , Ltd. , Foshan 528216, Guangdong, China
  • Received:2020-04-13 Online:2021-01-05 Published:2021-01-12
  • Contact: Zhenyu JIA

摘要:

采用壳聚糖为基材、果胶为交联剂制备了薄膜材料,考察了卡拉胶和淀粉为添加剂对该薄膜材料力学性能的影响。结果显示,不加卡拉胶、淀粉的果胶-壳聚糖复合聚合物薄膜材料由于不溶于模拟胃液和模拟肠液,不适合单独作为缓释胶囊材料。当加入卡拉胶和淀粉后,不仅可进一步增加薄膜材料的柔韧性、凝胶性、透明度和力学性能,还增加其在模拟肠液和胃液中的溶解性。果胶-壳聚糖、卡拉胶、淀粉的质量比为2∶1∶1,得到的薄膜材料不仅具有良好的成型性和弹性,也具有适中的胃液和肠液溶解性。将该材料制备成胶囊,在模拟胃液和模拟肠液环境考察其破壁缓释效果,结果显示,胶囊在模拟胃液和肠液中的溶解是一个缓慢过程,浸泡6h后,胶囊药物的缓释率大致为93%。

关键词: 壳聚糖, 胶囊材料, 果胶, 卡拉胶, 缓释

Abstract:

Films material was prepared through crosslinking of chitosan and pectin. The effects of carrageenan and starch as additives on the mechanical properties of the films were investigated. The results showed that the pectin-chitosan composite membrane material without carrageenan and starch was not suitable to be used as sustained-release capsule material alone because it was insoluble in simulated gastric solution and intestinal solution. When carrageenan and starch were added, the flexibility, gelatinization, transparency and mechanical properties of the films were further improved, and the solubility of the films in simulated intestinal and gastric solution was increased. When chitosan-pectin∶carrageenan∶starch had a mass ratio of 2∶1∶1, the film material not only had good formability and elasticity, but also had moderate solubility in gastric solution and intestinal solution. The results of the capsule degradation showed that the capsule dissolution was a slow process in the simulated gastric solution and intestinal solution, and the sustained release rate of the capsule was about 93% after 6h immersion.

Key words: chitosan, capsule material, pectin, carrageenan, sustained release

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