壳聚糖胶囊材料的制备及其缓释性能

doi:10.16085/j.issn.1000-6613.2020-0568

化工进展 ›› 2021, Vol. 40 ›› Issue (1): 339-345.DOI: 10.16085/j.issn.1000-6613.2020-0568

壳聚糖胶囊材料的制备及其缓释性能

刘其海¹^,²^,³(), 谢婉婷¹, 贾振宇¹^,²^,³(), 朱小花², 王荣辉²

^1.仲恺农业工程学院化学化工学院，广东广州 510225
^2.湛江博泰生物化工科技实业有限公司，广东湛江 524051
^3.广东维芊科技有限公司，广东佛山 528216

收稿日期:2020-04-13 出版日期:2021-01-05 发布日期:2021-01-12
通讯作者: 贾振宇
作者简介:刘其海（1977—），男，副教授，研究领域为生物质及天然高分子转化与应用。E-mail：lqh2003@163.com。
基金资助:
广东省省级科技计划(2016A010105022);广州市科技计划(201704020023);广东省促进经济发展专项(粤自然资源合[2019]016号);湛江市海洋经济创新发展示范市建设项目(湛海创2017C4A);湛江市科技发展专项资金竞争性分配项目(2016A02010);佛山市科技创新项目(2019)

Preparation of chitosan capsule materials and its sustained release properties

Qihai LIU¹^,²^,³(), Wanting XIE¹, Zhenyu JIA¹^,²^,³(), Xiaohua ZHU², Ronghui WANG²

^1.College of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, Guangdong, China
^2.Zhanjiang Botai Bio-Chemical Technology Industrial Co. , Ltd. , Zhanjiang 524051, Guangdong, China
^3.Guangdong Weiqian Technology Co. , Ltd. , Foshan 528216, Guangdong, China

Received:2020-04-13 Online:2021-01-05 Published:2021-01-12
Contact: Zhenyu JIA

摘要/Abstract

摘要：

采用壳聚糖为基材、果胶为交联剂制备了薄膜材料，考察了卡拉胶和淀粉为添加剂对该薄膜材料力学性能的影响。结果显示，不加卡拉胶、淀粉的果胶-壳聚糖复合聚合物薄膜材料由于不溶于模拟胃液和模拟肠液，不适合单独作为缓释胶囊材料。当加入卡拉胶和淀粉后，不仅可进一步增加薄膜材料的柔韧性、凝胶性、透明度和力学性能，还增加其在模拟肠液和胃液中的溶解性。果胶-壳聚糖、卡拉胶、淀粉的质量比为2∶1∶1，得到的薄膜材料不仅具有良好的成型性和弹性，也具有适中的胃液和肠液溶解性。将该材料制备成胶囊，在模拟胃液和模拟肠液环境考察其破壁缓释效果，结果显示，胶囊在模拟胃液和肠液中的溶解是一个缓慢过程，浸泡6h后，胶囊药物的缓释率大致为93%。

关键词: 壳聚糖, 胶囊材料, 果胶, 卡拉胶, 缓释

Abstract:

Films material was prepared through crosslinking of chitosan and pectin. The effects of carrageenan and starch as additives on the mechanical properties of the films were investigated. The results showed that the pectin-chitosan composite membrane material without carrageenan and starch was not suitable to be used as sustained-release capsule material alone because it was insoluble in simulated gastric solution and intestinal solution. When carrageenan and starch were added, the flexibility, gelatinization, transparency and mechanical properties of the films were further improved, and the solubility of the films in simulated intestinal and gastric solution was increased. When chitosan-pectin∶carrageenan∶starch had a mass ratio of 2∶1∶1, the film material not only had good formability and elasticity, but also had moderate solubility in gastric solution and intestinal solution. The results of the capsule degradation showed that the capsule dissolution was a slow process in the simulated gastric solution and intestinal solution, and the sustained release rate of the capsule was about 93% after 6h immersion.

Key words: chitosan, capsule material, pectin, carrageenan, sustained release

中图分类号:

TQ281

刘其海, 谢婉婷, 贾振宇, 朱小花, 王荣辉. 壳聚糖胶囊材料的制备及其缓释性能[J]. 化工进展, 2021, 40(1): 339-345.

Qihai LIU, Wanting XIE, Zhenyu JIA, Xiaohua ZHU, Ronghui WANG. Preparation of chitosan capsule materials and its sustained release properties[J]. Chemical Industry and Engineering Progress, 2021, 40(1): 339-345.

图/表 10

参考文献 9

1	DEORE K L, THOMBRE N A, GIDE P S. Formulation and development of tinidazole microspheres for colon targeted drug delivery system[J]. Journal of Pharmacy Research, 2013, 6(1): 158-165.
2	DAS S, CHAUDHURY A, NG K Y. Preparation and evaluation of zinc-pectin-chitosan composite particles for drug delivery to the colon: Role of chitosan in modifying in vitro and in vivo drug release[J]. International Journal of Pharmaceutics, 2011, 406(1/2): 11-20.
3	BAGLIOTTI M, ANDREIA, BEATRIZ S F C, et al. Films from resistant starch-pectin dispersions intended for colonic drug delivery[J]. Carbohydrate Polymers, 2014, 99(1): 140-149.
4	HIORTH M, SKOLEN T, SANDE S A. Immersion coating of pellet cores consisting of chitosan and calcium intended for colon drug delivery[J]. European Journal of Pharmaceutics and Biopharmaceutics, 2010, 75(2): 245-253.
5	WANG M J, XIE Y L, CHEN Z J, et al. Optimizing preparation of NaCS-chitosan complex to form a potential material for the colon-specific drug delivery system[J]. Journal of Applied Polymer Science, 2010, 117(5): 3001-3012.
6	HAMMAN J H. Chitosan based polyelectrolyte complexes as potential carrier materials in drug delivery systems[J]. South Africa Mar. Drugs, 2010, 8: 1305-1322.
7	MORRIS, KOK G A, HARDING M S, et al. Polysaccharide drug delivery systems based on pectin and chitosan[J]. Biotechnol. Genet. Eng. Rev., 2010, 27: 257-283.
8	BHATTARAI N N, GUNN J, ZHANG M Q. Chitosan-based hydrogels for controlled, localized drug delivery[J]. Advanced Drug Delivery Reviews, 2010, 9(1): 83-99.
9	PARK J H, SARAVANAKUMAR G, KIM K, et al. Targeted delivery of low molecular drugs using chitosan and its derivatives[J]. Advanced Drug Delivery Reviews, 2009, 62(1): 28-41.

样品名称	m（果胶-壳聚糖）∶m（卡拉胶）∶m（淀粉）	果胶-壳聚糖/g	卡拉胶/g	淀粉/g	甘油/g
薄膜样品1	1∶1∶1	2.0	2.0	2.0	2.0
薄膜样品2	2∶1∶1	4.0	2.0	2.0	2.7
薄膜样品3	3∶1∶1	6.0	2.0	2.0	3.3

样品名称	m（果胶-壳聚糖）∶m（卡拉胶）∶m（淀粉）	果胶-壳聚糖/g	卡拉胶/g	淀粉/g	甘油/g
薄膜样品1	1∶1∶1	2.0	2.0	2.0	2.0
薄膜样品2	2∶1∶1	4.0	2.0	2.0	2.7
薄膜样品3	3∶1∶1	6.0	2.0	2.0	3.3

壳聚糖		果胶		干凝胶质量/g	产物收率 /%
溶液体积/mL	质量/g	溶液体积/mL	质量/g	干凝胶质量/g	产物收率 /%
100	1.02	20	1.00	1.33	67.01
100	1.01	40	2.01	2.30	76.32
100	1.01	60	3.02	3.38	84.30
100	1.03	80	4.01	3.51	70.61
100	1.01	100	5.03	3.70	61.51

壳聚糖		果胶		干凝胶质量/g	产物收率 /%
溶液体积/mL	质量/g	溶液体积/mL	质量/g	干凝胶质量/g	产物收率 /%
100	1.02	20	1.00	1.33	67.01
100	1.01	40	2.01	2.30	76.32
100	1.01	60	3.02	3.38	84.30
100	1.03	80	4.01	3.51	70.61
100	1.01	100	5.03	3.70	61.51

材料名称	TS/MPa	伸长率/%
果胶-壳聚糖	10.42	33.81
果胶-壳聚糖/卡拉胶/淀粉	18.52	59.25
明胶	19.31	104.89

壳聚糖胶囊材料的制备及其缓释性能

Preparation of chitosan capsule materials and its sustained release properties

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

图/表 10

参考文献 9

相关文章 15

编辑推荐

Metrics

本文评价

[1]	王少凡, 周颖, 郝康安, 黄安荣, 张如菊, 吴翀, 左晓玲. 具有pH响应性的自愈合蓝光水凝胶[J]. 化工进展, 2023, 42(9): 4837-4846.
[2]	刘淑琼, 吴芳芳, 刘瑞来, 许祯毅. 聚乳酸/壳聚糖/氧化石墨烯载阿司匹林仿生支架的制备与表征[J]. 化工进展, 2023, 42(8): 4362-4371.
[3]	王林, 辛梅华, 李明春, 陈琦, 毛扬帆. 季铵化/磺化壳聚糖的制备及其抗生物被膜活性[J]. 化工进展, 2023, 42(5): 2577-2585.
[4]	王林, 辛梅华, 李明春, 张涛, 毛扬帆. 烷基季铵化壳聚糖的制备及其抗生物被膜的活性[J]. 化工进展, 2023, 42(4): 1995-2002.
[5]	朱添宇, 孙琳, 任超, 罗雄麟. 基于全周期持续节能的换热网络滑动窗口分析与裕量缓释优化控制[J]. 化工进展, 2023, 42(3): 1195-1205.
[6]	李鲁, 鲍穗, 张李明, 汪然, 陶正红, 杨兴祥. 卡拉胶-魔芋胶复合凝胶基香精微胶囊的制备与表征[J]. 化工进展, 2022, 41(S1): 376-381.
[7]	冯颖, 赵孟杰, 崔倩, 解玉鞠, 张建伟, 董鑫. 分子模拟技术在壳聚糖功能材料开发和应用中的研究进展[J]. 化工进展, 2022, 41(8): 4241-4253.
[8]	李梓泳, 陈龙, 马文丹, 周红军, 周新华. PDMDAAC改性玉米醇溶蛋白负载阿维菌素纳米颗粒的制备与性能[J]. 化工进展, 2022, 41(4): 2068-2074.
[9]	周丽莎, 李若男, 卞雨洁, 陈舜胜. TOCNF与磁性羧甲基壳聚糖纳米粒子复合物的制备及吸附Pb²⁺的特性[J]. 化工进展, 2022, 41(2): 901-910.
[10]	郑细鸣, 范荣玉. 微孔聚丙烯膜表面壳聚糖季铵盐的共价修饰及其抗菌性能[J]. 化工进展, 2021, 40(1): 332-338.
[11]	刘旭光, 辛梅华, 李明春, 许军凯, 王林. 壳聚糖/N-乙烯基吡咯烷酮接枝共聚物的制备及其性能[J]. 化工进展, 2020, 39(9): 3535-3542.
[12]	张毅, 姜迎雪, 张昊. 季铵型改性壳聚糖的制备及其在兔毛织物抗菌整理中的应用[J]. 化工进展, 2020, 39(7): 2810-2816.
[13]	郑云龙,王进美,孙正琪,秦智成,周娅楠. 壳聚糖/明胶抗菌微胶囊的制备及其应用[J]. 化工进展, 2020, 39(3): 1137-1144.
[14]	储李娜,敖先权,陈前林,郭妤,曹阳. 改性聚乙烯醇添加酒糟制备缓释肥包膜材料的表征及其性能[J]. 化工进展, 2020, 39(2): 627-634.
[15]	孙琳, 杨明达, 罗雄麟. 基于持续节能的换热网络缓释优化[J]. 化工进展, 2020, 39(10): 3941-3948.