化工进展 ›› 2016, Vol. 35 ›› Issue (S2): 276-278.DOI: 10.16085/j.issn.1000-6613.2016.s2.046

• 生物与医药化工 • 上一篇    下一篇

苯并噻唑类离子液体对斑马鱼抗氧化机制的毒性影响

陈彦文, 罗英杰, 杨小雪, 姚舜, 宋航   

  1. 四川大学化学工程学院, 四川 成都 610065
  • 收稿日期:2016-09-26 出版日期:2016-12-31 发布日期:2016-12-22
  • 通讯作者: 宋航,教授。E-mail:hangsong@vip.sina.com。
  • 作者简介:陈彦文(1991-),女,硕士研究生,从事新型材料开发及毒性研究。

Toxic effect of benzothiazole ionic liquids on antioxidation mechanism of zebrafish

CHEN Yanwen, LUO Yingjie, YANG Xiaoxue, YAO Shun, SONG Hang   

  1. Department of Pharmaceutical and Bioglocial Engineering, Sichuan University, Chengdu 610065, Sichuan, China
  • Received:2016-09-26 Online:2016-12-31 Published:2016-12-22

摘要: 随着离子液体的应用和发展不断推进,其毒性影响得到广泛关注,其中苯并噻唑离子液体仍处于初步发展阶段,其毒性方面的研究还有待完善。斑马鱼作为水质污染的生物指标,广泛应用于评测水体安全的研究中。本文选用斑马鱼的抗氧化机制中SOD酶活性作为测定指标,采用半静态水体染毒法取得染毒鱼体的肝组织,对其SOD活性进行测定,得到酸性及中性苯并噻唑类离子液体对水生生物的抗氧化机制的影响,及对水生生物的毒性影响。研究结果表明,苯并噻唑类离子液体致使斑马鱼肝组织内的SOD活性呈现下降趋势,对斑马鱼产生致死毒性影响,其中酸性苯并噻唑离子液体对斑马鱼具有更显著的毒性影响,而相同阴离子的酸性和中性离子液体有相同的毒性水平。

关键词: 离子液体, 斑马鱼, 毒性, 超氧化物歧化酶

Abstract: With the wide application and development of ionic liquids,the effect of their toxicity gained more attention.Among the kinds of ionic liquids,the benzothiazole ionic liquids are on the period of initial development,and the study of toxicity has to be perfect.Zebrafish are mark of water contamination monitor,and applied to test the safety of aqueous solution.This study used the SOD activity from antioxidation mechanism of zebrafish as index,chose the method of semi-static contamination aqueous solution to get the SOD activity of liver tissue,and explore the effect of acid and neutral ionic liquid on antioxidation mechanism of aquatic organism.The results proved that the benzothiazole ionic liquids lead the SOD activity of liver to decrease,and took lethal effect on zebrafish.Besides the acid benzothiazole ionic liquid showed stronger toxicity than neutral,and the same anion ionic liquid had the same level of toxicity.

Key words: ionic liquid, zebrafish, toxicity, SOD

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