化工进展 ›› 2021, Vol. 40 ›› Issue (6): 3346-3362.DOI: 10.16085/j.issn.1000-6613.2020-1297
收稿日期:
2020-07-09
修回日期:
2020-08-27
出版日期:
2021-06-06
发布日期:
2021-06-22
通讯作者:
高云玲
作者简介:
安宁(1995—),男,硕士研究生,研究方向为分子探针。E-mail:基金资助:
Received:
2020-07-09
Revised:
2020-08-27
Online:
2021-06-06
Published:
2021-06-22
Contact:
GAO Yunling
摘要:
次氯酸/次氯酸根是活性氧化物中重要的信号分子,在生物医药和环境安全等方面发挥着重要作用。反应型荧光探针基于出色的灵敏度、实时成像和生物兼容性好等特点,广泛应用于HClO/ClO-的检测。本文评述了近5年反应型HClO/ClO-荧光探针的研究进展,包括反应型HClO/ClO-荧光探针的设计策略和识别机理,并从HClO/ClO-引发的反应机理角度(碳碳双键的反应、硫族化合物的反应、醛肟基团的反应、腙/席夫碱的反应、酰肼/磺酰肼的反应、N,N-二甲基硫代氨基甲酸酯的反应和苯硼酸/硼酸酯的反应)概述了反应型HClO/ClO-荧光探针的特点和实际应用,指出反应型HClO/ClO-荧光探针的发展方向是合成性能优异的识别基团,构建选择性好、水溶性好、低荧光背景、光化学性能稳定和生物毒性低的反应型近红外HClO/ClO-荧光探针,实现对生物体内外HClO/ClO-的可视化检测及机理探索。
中图分类号:
安宁, 高云玲. 反应型HClO/ClO-荧光探针的研究进展[J]. 化工进展, 2021, 40(6): 3346-3362.
AN Ning, GAO Yunling. Reaction-based fluorescent probes for detection of HClO/ClO-[J]. Chemical Industry and Engineering Progress, 2021, 40(6): 3346-3362.
荧光探针编号 | 量子产率 | 响应速度/s | 检测限/nmol·L-1 | 应用 | 颜色的变化 | 参考文献 |
---|---|---|---|---|---|---|
1 | — | 215 | 31.6 | L929细胞 | 无 | [ |
2 | 0.85→0.014 | 30 | 41.8 | RAW264.7细胞 | 无 | [ |
3 | 0.233→0.392 | 40 | 321 | RAW264.7细胞 | 无 | [ |
4 | — | 120 | 182 | HeLa细胞 | 红色变无色 | [ |
5 | — | 210 | 13.2 | HeLa细胞 | 红色变无色 | [ |
6 | — | 13 | 25 | RAW264.7细胞 | 无 | [ |
7 | — | — | 80 | 水体样本 | 蓝色变粉红色 | [ |
8 | — | — | — | HepG2细胞 | 无 | [ |
9 | 0.28→0.05 | 30 | 165 | HeLa细胞 | 黄色变无色 | [ |
10 | 0.003→0.216 | 120 | 4.1 | RAW264.7细胞 | 蓝色变紫色 | [ |
11 | 0.01→0.28 | 10 | 22.6 | HepG2细胞 | 蓝色变紫色 | [ |
12 | 0.051→0.074 | 10 | 449.76 | PC12细胞 | 淡黄色变无色 | [ |
13 | 0.0013→0.22 | 60 | 53 | HeLa细胞 | 无 | [ |
14 | — | — | 39 | 水体样本 | 粉红变浅黄色 | [ |
15 | 0.02→0.32 | 60 | 120 | RAW264.7细胞 | 无 | [ |
16 | 0.0012→0.0094 | — | 2330 | RAW264.7细胞 | 无 | [ |
17 | 0.02→0.43 | 300 | 737 | 水体样本 | 紫色变绿色 | [ |
18 | — | 120 | 210 | A549细胞 | 黄色变无色 | [ |
19 | 0.07→0.55 | 20 | 8.3 | RAW264.7细胞 | 无 | [ |
20 | — | 60 | 580 | CHO细胞 | 无 | [ |
21 | — | 60 | 790 | CHO细胞 | 无 | [ |
22 | 0.006→0.389 | 3s | 2.88 | RAW264.7细胞 | 无 | [ |
23 | 0.059→0.56 | 210 | 228 | HepG2细胞 | 粉红色变橙色 | [ |
24 | 0.0094→0.1647 | 30 | 49 | RAMOS细胞 | 无 | [ |
25 | — | 210 | 14 | HeLa细胞 | 无 | [ |
26 | 0.166→0.186 | 30 | 334 | RAMOS细胞 | 无 | [ |
27 | — | 90 | 32 | HeLa细胞 | 无 | [ |
28 | 0.0045→0.073 | 3 | 270 | RAW264.7细胞 | 无 | [ |
29 | — | 40 | 128 | MRC-5细胞和斑马鱼细胞 | 黄色变无色 | [ |
30 | — | 20 | 11.4 | RAMOS细胞 | 无色变黄色 | [ |
31 | — | 300 | 20 | 水体样本 | 无 | [ |
32 | 0.05→0.19 | 15 | 86 | HeLa细胞 | 无 | [ |
33 | — | 20 | 20.5 | 4T1细胞 | 无 | [ |
34 | — | 300 | 164 | RAW264.7细胞 | 无 | [ |
35 | 0.001→0.22 | 5 | 24.3 | HeLa细胞 | 无 | [ |
36 | 0.028→0.371 | 5 | 3.30 | RAW264.7细胞 | 无 | [ |
37 | — | 60 | 0.9 | RAW264.7细胞 | 无 | [ |
38 | — | 180 | 28.2 | HeLa细胞 | 无 | [ |
39 | — | 120 | 63 | 试纸条应用 | 浅绿色变橙色 | [ |
40 | 0.019→0.066 | 30 | 15.7 | HepG2细胞 | 黄色变红色 | [ |
41 | — | 60 | 400 | RAW264.7细胞 | 浅黄色变红色 | [ |
表1 反应型HClO/ClO-荧光探针的比较
荧光探针编号 | 量子产率 | 响应速度/s | 检测限/nmol·L-1 | 应用 | 颜色的变化 | 参考文献 |
---|---|---|---|---|---|---|
1 | — | 215 | 31.6 | L929细胞 | 无 | [ |
2 | 0.85→0.014 | 30 | 41.8 | RAW264.7细胞 | 无 | [ |
3 | 0.233→0.392 | 40 | 321 | RAW264.7细胞 | 无 | [ |
4 | — | 120 | 182 | HeLa细胞 | 红色变无色 | [ |
5 | — | 210 | 13.2 | HeLa细胞 | 红色变无色 | [ |
6 | — | 13 | 25 | RAW264.7细胞 | 无 | [ |
7 | — | — | 80 | 水体样本 | 蓝色变粉红色 | [ |
8 | — | — | — | HepG2细胞 | 无 | [ |
9 | 0.28→0.05 | 30 | 165 | HeLa细胞 | 黄色变无色 | [ |
10 | 0.003→0.216 | 120 | 4.1 | RAW264.7细胞 | 蓝色变紫色 | [ |
11 | 0.01→0.28 | 10 | 22.6 | HepG2细胞 | 蓝色变紫色 | [ |
12 | 0.051→0.074 | 10 | 449.76 | PC12细胞 | 淡黄色变无色 | [ |
13 | 0.0013→0.22 | 60 | 53 | HeLa细胞 | 无 | [ |
14 | — | — | 39 | 水体样本 | 粉红变浅黄色 | [ |
15 | 0.02→0.32 | 60 | 120 | RAW264.7细胞 | 无 | [ |
16 | 0.0012→0.0094 | — | 2330 | RAW264.7细胞 | 无 | [ |
17 | 0.02→0.43 | 300 | 737 | 水体样本 | 紫色变绿色 | [ |
18 | — | 120 | 210 | A549细胞 | 黄色变无色 | [ |
19 | 0.07→0.55 | 20 | 8.3 | RAW264.7细胞 | 无 | [ |
20 | — | 60 | 580 | CHO细胞 | 无 | [ |
21 | — | 60 | 790 | CHO细胞 | 无 | [ |
22 | 0.006→0.389 | 3s | 2.88 | RAW264.7细胞 | 无 | [ |
23 | 0.059→0.56 | 210 | 228 | HepG2细胞 | 粉红色变橙色 | [ |
24 | 0.0094→0.1647 | 30 | 49 | RAMOS细胞 | 无 | [ |
25 | — | 210 | 14 | HeLa细胞 | 无 | [ |
26 | 0.166→0.186 | 30 | 334 | RAMOS细胞 | 无 | [ |
27 | — | 90 | 32 | HeLa细胞 | 无 | [ |
28 | 0.0045→0.073 | 3 | 270 | RAW264.7细胞 | 无 | [ |
29 | — | 40 | 128 | MRC-5细胞和斑马鱼细胞 | 黄色变无色 | [ |
30 | — | 20 | 11.4 | RAMOS细胞 | 无色变黄色 | [ |
31 | — | 300 | 20 | 水体样本 | 无 | [ |
32 | 0.05→0.19 | 15 | 86 | HeLa细胞 | 无 | [ |
33 | — | 20 | 20.5 | 4T1细胞 | 无 | [ |
34 | — | 300 | 164 | RAW264.7细胞 | 无 | [ |
35 | 0.001→0.22 | 5 | 24.3 | HeLa细胞 | 无 | [ |
36 | 0.028→0.371 | 5 | 3.30 | RAW264.7细胞 | 无 | [ |
37 | — | 60 | 0.9 | RAW264.7细胞 | 无 | [ |
38 | — | 180 | 28.2 | HeLa细胞 | 无 | [ |
39 | — | 120 | 63 | 试纸条应用 | 浅绿色变橙色 | [ |
40 | 0.019→0.066 | 30 | 15.7 | HepG2细胞 | 黄色变红色 | [ |
41 | — | 60 | 400 | RAW264.7细胞 | 浅黄色变红色 | [ |
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