发酵法生产1,3-丙二醇的研究进展

doi:10.16085/j.issn.1000-6613.2017.04.032

摘要/Abstract

摘要： 1，3-丙二醇是一种重要的化合物，近年来由于其用途的不断拓宽而越来越受到广泛重视。生物合成法生产1，3-丙二醇具有绿色高效、使用可再生能源等特点，是目前最具前景的生产方式。本文从发酵菌种、发酵工艺、发酵过程优化和精制提纯几个方面对发酵法生产1，3-丙二醇的研究现状进行了介绍。提出为使生物法生产1，3-丙二醇在成本上与化学法相比更具优势，在提高产量的同时应该引入新技术、新手段对发酵过程进行强化，使得过程更加精准且易于控制；同时指出综合考虑经济性与能耗问题，对发酵与分离的全过程进行整合，是今后发酵法生产1，3-丙二醇实现产业化的研究重点。

关键词: 1, 3-丙二醇, 发酵, 生物转化, 甘油

Abstract: 1,3-propanediol is an important chemical compound,which has recently received more and more attention due to its wide applications. Synthesizing 1,3-propanediol via the biological method has some merits,such as green,high efficiency,and sustainable. This method is the most promising for the 1,3-propanediol production.In this paper,the research advances on production of 1,3-propanediol by fermentation were reviewed with regard to fermentative strains,fermentation process,process optimization and purification. To have a low cost advantage over the other chemical synthesizes,the biological method needs to increase the concentration of 1,3-propanediol,to strengthen the fermentation process that is more accurate and easier control. Economy and energy consumption need to be considered to integrate the whole process of fermentation and separation,which should be the focus of research and industrial production of 1,3-propanediol by biological process in the future.

Key words: 1,3-propanediol, fermentation, bioconversion, glycerol

中图分类号:

TQ923

李晓姝, 张霖, 高大成, 师文静, 樊亚超. 发酵法生产1,3-丙二醇的研究进展[J]. 化工进展, 2017, 36(04): 1395-1403.

LI Xiaoshu, ZHANG Lin, GAO Dacheng, SHI Wenjing, FAN Yachao. Progress on the production of 1,3-propanediol by fermentation[J]. Chemical Industry and Engineering Progress, 2017, 36(04): 1395-1403.

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