Abstract:

Solution crystallization is one of the most important product separation, purification and functionalization techniques in chemical industry, which is widely used in pharmaceutical, food, fine chemicals and other fields. The nucleation and growth process of crystals in solution crystallization will determine the key physicochemical properties such as crystal form, crystal habit, particle size and purity of the final crystal products. Therefore, process intensification of solution crystallization, especially crystal nucleation and growth process, can help to improve the process efficiency and meet the different performance requirements of crystal products. In this paper, process intensification strategies for nucleation and crystal growth in solution crystallization are systematically reviewed, including the technologies of confined space, physical fields, additives and template agents. The advantages and limitations of various process intensification strategies are discussed, and the main research focuses and development prospects of solution crystallization process intensification strategies are summarized.

Key words: crystallization, nucleation, growth, particle size distribution, process intensification

摘要：

溶液结晶是化学工业中最重要的产品分离、纯化和功能化技术之一，广泛应用于医药、食品、精细化工等领域。溶液结晶中晶体的成核和生长过程将决定最终晶体产品的晶型、晶习、粒度、纯度等关键质量指标。因此，对溶液结晶过程，尤其是晶体成核和生长过程进行强化既有利于提高过程效率，也有助于满足晶体产品不同的性能需求。本文围绕晶体成核和生长强化这一关键问题，从受限空间、物理场、添加剂和模板剂等方面系统综述了溶液结晶中的过程强化策略。探讨了各种过程强化策略的优点和局限性，并总结了溶液结晶过程强化策略的主要研究重点和发展前景。

关键词: 结晶, 成核, 生长, 粒度分布, 过程强化