Chemical Industry and Engineering Progress ›› 2023, Vol. 42 ›› Issue (8): 4015-4028.DOI: 10.16085/j.issn.1000-6613.2023-0500

Previous Articles     Next Articles

Research progress on chemical modification of polyether ether ketone for the high bioactivity

CHEN Junjun1,2(), FEI Chang’en1, DUAN Jintang1,2, GU Xueping1,2, FENG Lianfang1,2, ZHANG Cailiang1,2()   

  1. 1.State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, Zhejiang, China
    2.Institute of Zhejiang University-Quzhou, Quzhou 324000, Zhejiang, China
  • Received:2023-03-31 Revised:2023-05-27 Online:2023-09-19 Published:2023-08-15
  • Contact: ZHANG Cailiang

高生物活性聚醚醚酮化学改性研究进展

陈俊俊1,2(), 费昌恩1, 段金汤1,2, 顾雪萍1,2, 冯连芳1,2, 张才亮1,2()   

  1. 1.化学工程联合国家重点实验室,浙江大学化学工程与生物工程学院,浙江 杭州 310027
    2.浙江大学衢州研究院,浙江 衢州 324000
  • 通讯作者: 张才亮
  • 作者简介:陈俊俊(1997—),男,硕士研究生,研究方向为聚合物反应工程。E-mail:junjunchen@zju.edu.cn
  • 基金资助:
    国家重点研发计划(2020YFC1107100);浙江大学衢州研究院科技计划(IZQ2020KJ2005)

Abstract:

Because of its hydrophobicity and biological inertness, polyether ether ketone (PEEK) used as an orthopedic material is difficult to bond with surrounding cells and bone tissues. It is the most effective method to improve cell adhesion, proliferation and osteogenic differentiation on the surface of PEEK materials by introducing biologically active groups into the molecular chain of PEEK. Based on the different introduction positions of functional groups, the chemical modification of PEEK is classified into three types: benzene cyclic modification, ketone modification and copolymerization modification. The principles and characteristics of these different chemical modification methods and their impact on the biological activity of PEEK materials are emphatically reviewed. The benzene cyclic modification mainly involved the introduction of functional groups such as carboxyl groups through strong acid treatment, resulting in the residual sulfur or nitrate compounds that has a certain toxic effect on cells. Ketone group modification used reagents such as amines and sodium borohydride to react with the ketone group and further introduced functional groups through grafting, however, it would destroy the ether-ketone ratio on the main chain of PEEK, affecting its physical and thermal properties. Introducing bioactive functional groups into the side chain of PEEK by copolymerization methods such as electrophilic addition, nucleophilic addition or halogenation-modification can maintain the ether and ketone ratio in the polymer backbone and improve the bioactivity, which has good application prospects. On the basis of chemical modification, studying the synergistic effect of various functional groups and further introducing physical modification to optimize comprehensive performance for different scenarios is the development trend for expanding the application of PEEK in the medical field.

Key words: polyether ether ketone, chemical modification, copolymerization modification, functional modification, biological activity

摘要:

由于聚醚醚酮(PEEK)表面疏水及生物惰性,用作骨科材料难以与周围细胞、骨组织结合。通过化学改性在PEEK分子链中引入具有生物活性的功能化基团是提高其表面细胞黏附、增殖和成骨分化能力最有效的方式。基于功能化基团引入位置的不同,本文将PEEK化学改性分为苯环位改性、酮基位改性和共聚改性等三种,并且重点综述了这些不同化学改性方法的原理和特性及其对PEEK材料生物活性的影响。苯环位改性主要是通过强酸处理引入羧基等官能团,但会残留含硫或含硝化合物,对细胞有一定的毒害作用;酮基位改性是通过胺类、硼氢化钠等试剂与酮基反应,进一步接枝引入功能化基团,但是会破坏PEEK主链上的醚酮比,影响物理性能和热性能。通过亲电、亲核及卤代改性等共聚方式在PEEK侧链引入功能化基团,能保持聚合物主链醚酮比基本不变,同时提升材料生物活性,具有良好的应用前景。在化学改性的基础上,研究多种功能基团的协同作用,进一步引入物理改性,优化面向不同场景的综合性能,是拓宽其在医疗领域应用的发展趋势。

关键词: 聚醚醚酮, 化学改性, 共聚改性, 功能化改性, 生物活性

CLC Number: 

京ICP备12046843号-2;京公网安备 11010102001994号
Copyright © Chemical Industry and Engineering Progress, All Rights Reserved.
E-mail: hgjz@cip.com.cn
Powered by Beijing Magtech Co. Ltd