Abstract: As a potential platform compound,2,3-butanediol is used widely and can replace the traditional platforms——four carbon hydrocarbons. With the requirements of energy security and environmental protection,biological refinery of 2,3-butanediol have gained substantial interest due to its obvious advantages over the chemical method. However,due to the high boiling point and hydrophilicity of 2,3-butanediol,it is very difficult to be recovered from fermentation broth,which has become the bottle-neck of industrial production of 2,3-butanediol. Therefore,it is important to develop cost effective process to separate 2,3-butanediol. The progress is reviewed on the downstream processing of 2,3-butanediol fermentation. The process contains mainly three steps:solid-liquid separation,deep treatment of broth and purification of 2,3-butanediol. Many technologies have been involved,such as centrifugation,flocculation,membrane filtration,ion exchange,electrodialysis,extraction,distillation and so on,and their optimization and combinations. In the future,researchers should focus on the effective integration of existing technologies and development of new separation process.

Key words: 2,3-butanediol, bio-refinery, separation

摘要： 2,3-丁二醇应用广泛，是一种潜在的平台化合物，可以用于替代传统平台化合物——四碳烃。基于能源安全及绿色环保的需求，生物炼制制备2,3-丁二醇受到人们的青睐。与化学法相比，生物炼制制备2,3-丁二醇具有明显的优势。然而，2,3-丁二醇的高沸点及强极性的特点使它难以从发酵液中分离。这成为了生物炼制2,3-丁二醇工艺工业化的瓶颈。因此，开发高效价廉的2,3-丁二醇分离工艺成为研究的重点。本文综述了从发酵液中分离2,3-丁二醇工艺的研究进展。2,3-丁二醇的分离主要包括固液分离、发酵液深处理及2,3-丁二醇精制3个方面，涉及的分离技术包括离心、絮凝、膜过滤、离子交换、电渗析、萃取、精馏等以及相关技术的优化和耦合。提出今后的研究重点在于现有分离工艺的高效整合及新型分离工艺的有效突破。

关键词: 2,3-丁二醇, 生物炼制, 分离