熔体静电纺丝直写技术在组织工程中的应用进展

doi:10.16085/j.issn.1000-6613.2019-0028

化工进展 ›› 2019, Vol. 38 ›› Issue (08): 3756-3762.DOI: 10.16085/j.issn.1000-6613.2019-0028

熔体静电纺丝直写技术在组织工程中的应用进展

姚子琪¹(),马东明¹,雷文龙¹,焦志伟¹,李好义¹,徐小东²,张有忱¹()

1. 北京化工大学机电工程学院，北京 100029
2. 中日友好医院，北京 100029

收稿日期:2019-01-04 出版日期:2019-08-05 发布日期:2019-08-05
通讯作者: 张有忱
作者简介:姚子琪（1995—），男，硕士研究生，研究方向为熔体静电纺丝在组织工程中的应用。E-mail：563211224@qq.com。
基金资助:
广东省省级科技计划(2016B090915001);国家自然科学基金(51603009)

Progress in melt electrospinning direct writing technology intissue engineering

Ziqi YAO¹(),Dongming MA¹,Wenlong LEI¹,Zhiwei JIAO¹,Haoyi LI¹,Xiaodong XU²,Youchen ZHANG¹()

1. College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing 100029, China
2. China-Japanese Friendship Hospital, Beijing 100029, China

Received:2019-01-04 Online:2019-08-05 Published:2019-08-05
Contact: Youchen ZHANG

摘要/Abstract

摘要：

熔体静电纺丝直写技术以其纤维直径、沉积形貌可控性高及无溶剂残留等优势，为高强度复杂形貌可控仿生组织工程（TE）支架的制备提供了巨大的空间，成为近年来的研究热点。本文首先简述了熔体静电纺丝直写技术相对于各类其他TE支架制备方法的优势；其次从工艺调控方面综述了熔体静电纺丝直写技术的工艺研究进展，并总结了实现复杂可控形貌TE支架的调控方法；随后从支架材料、形貌表征和细胞培养效果等方面综述了熔体静电纺丝直写技术的TE应用进展，并概括了该技术制备的TE拓扑结构支架的种类及特点；最后指出熔体静电纺丝直写技术具有广阔的研究前景，且该技术应以制备仿生、材料多样化以及复合支架为研究重点。

关键词: 熔体静电纺丝, 直写技术, 纤维, 组织工程, 支架

Abstract:

The melt electrospinning direct writing technology provides a huge space for the preparation of high-strength complex morphology controllable biomimetic tissue engineering (TE) scaffolds due to its high controllability of fiber diameter and deposition morphology, solvent-free residue and other advantages. It has become a research hotspot in recent years. First, this paper briefly describes the advantages of melt electrospinning direct writing technology over various other TE scaffold preparation methods; secondly, the process research progress of melt electrospinning direct writing technology is reviewed from the aspects of process regulation, and the control methods for implementing complex controllable topography TE scaffold are summarized; then the progress of TE application of melt electrospinning direct writing technology is reviewed from the aspects of scaffold materials, morphological characterization and cell culture effects, in addition, the types and characteristics of TE topological structure scaffolds prepared by this technology are summarized; finally, it is pointed out that the melt electrospinning direct writing technology has broad research prospects, and the technology should focus on the preparation of bionics, material diversification and composite scaffolds.

Key words: melt electrospinning, direct writing technology, fiber, tissue engineering, scaffolds

中图分类号:

TS155.6

姚子琪,马东明,雷文龙,焦志伟,李好义,徐小东,张有忱. 熔体静电纺丝直写技术在组织工程中的应用进展[J]. 化工进展, 2019, 38(08): 3756-3762.

Ziqi YAO,Dongming MA,Wenlong LEI,Zhiwei JIAO,Haoyi LI,Xiaodong XU,Youchen ZHANG. Progress in melt electrospinning direct writing technology intissue engineering[J]. Chemical Industry and Engineering Progress, 2019, 38(08): 3756-3762.

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熔体静电纺丝直写技术在组织工程中的应用进展

Progress in melt electrospinning direct writing technology intissue engineering

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