化工进展 ›› 2019, Vol. 38 ›› Issue (08): 3742-3755.DOI: 10.16085/j.issn.1000-6613.2018-2184

• 材料科学与技术 • 上一篇    下一篇

核壳型磁性荧光纳米复合材料的制备及其应用研究进展

付绒1,2(),杨春林3,胡燕燕1,2,欧梅桂1,2()   

  1. 1. 贵州大学材料与冶金学院,贵州 贵阳 550025
    2. 高性能金属结构材料与制造技术国家地方联合工程实验室,贵州 贵阳550025
    3. 贵阳学院化学与材料工程学院,贵州 贵阳 550003
  • 收稿日期:2018-11-08 出版日期:2019-08-05 发布日期:2019-08-05
  • 通讯作者: 欧梅桂
  • 作者简介:付绒(1994—),硕士研究生,研究方向为功能材料。E-mail:1328814114@qq.com
  • 基金资助:
    贵州省教育厅工程研究中心项目(黔教合KY字(2017);贵州省科学技术基金(黔科合基础(2018);贵州省教育厅科技人才成长项目(黔教合KY字(2017)

Progress in preparation and application of core-shell structure nanocomposites with magnetism and fluorescence

Rong FU1,2(),Chunlin YANG3,Yanyan HU1,2,Meigui OU1,2()   

  1. 1. College of Materials and Metallurgy, University of Guizhou, Guiyang 550025, Guizhou, China
    2. National Local Joint Engineering Laboratory for High Performance Metal Structure Materials and Manufacturing Technology, Guiyang 550025, Guizhou, China
    3. College of Chemistry and Materials engineering, Guiyang University, Guiyang 550003, Guizhou, China
  • Received:2018-11-08 Online:2019-08-05 Published:2019-08-05
  • Contact: Meigui OU

摘要:

核壳型磁性荧光纳米复合材料是材料领域的研究热点之一,该材料呈现了单一材料无法同时兼有的磁响应性及荧光特性,因此被广泛地应用于生物医疗领域,提高了疾病诊断的效率和准确率,改进了癌症治疗技术。本文简单介绍了具有核壳结构的磁性荧光纳米复合粒子的4种形成机理、一些比较常用的制备方法及其各自的优缺点;重点介绍了纳米复合粒子的表面修饰方法,主要包括表面钝化及表面功能化两大类;对核壳结构磁性荧光纳米复合材料在多模态分子影像、药物的靶向运输与可控释放、癌症的热疗法及光动力疗法等方面的应用作了阐述。最后展望了核壳型磁性荧光纳米复合材料未来的发展趋势,并针对研究过程中所存在的关键问题,提出了今后进一步研究的主要方向为寻找多功能材料的最佳组合及组装方式、优化整合表面修饰剂的性能和明确材料在体内的毒性及代谢情况等。

关键词: 磁性, 荧光, 制备方法, 表面修饰, 生物医学应用

Abstract:

Core-shell structured nanocomposites with magnetic and fluorescent properties are one of the research hotspots in the field of materials. The nanocomposites has not only magnetic responsiveness but also fluorescence, presenting characteristics that cannot be simultaneously achieved by a single material. Therefore, they have been widely used in the field of biological medicine and have improved the efficiency and accuracy of disease diagnosis to elevate the techniques of cancer treatment. This paper briefly introduced the four formation mechanisms of core-shell structured nanocomposites with magnetism and fluorescence and a few commonly used preparation methods. The advantages and disadvantages of these methods were analyzed respectively. The surface modification methods (surface passivation and surface functionalization) of nanoparticles were mainly introduced. Moreover, the application of core-shell magnetic and fluorescent nanocomposites in multimodal molecular imaging, targeted transport and controlled release of drugs, thermal therapy and photodynamic therapy for cancer were expounded. Finally, the developing trend of core-shell structured nanocomposites with magnetic and fluorescent was prospected. According to the main problems in the current research, the main research direction in the future was pointed out: finding the best combination and assembly method for multifunctional materials, optimizing and integrating the properties of surface modifier, identifying the toxicity and metabolism of materials in the body, etc.

Key words: magnetism, fluorescence, preparation method, surface modification, biomedical applications

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