核壳型磁性荧光纳米复合材料的制备及其应用研究进展

doi:10.16085/j.issn.1000-6613.2018-2184

化工进展 ›› 2019, Vol. 38 ›› Issue (08): 3742-3755.DOI: 10.16085/j.issn.1000-6613.2018-2184

核壳型磁性荧光纳米复合材料的制备及其应用研究进展

付绒^1,²(),杨春林³,胡燕燕^1,²,欧梅桂^1,²()

1. 贵州大学材料与冶金学院，贵州贵阳 550025
2. 高性能金属结构材料与制造技术国家地方联合工程实验室，贵州贵阳550025
3. 贵阳学院化学与材料工程学院，贵州贵阳 550003

收稿日期:2018-11-08 出版日期:2019-08-05 发布日期:2019-08-05
通讯作者: 欧梅桂
作者简介:付绒（1994—），硕士研究生，研究方向为功能材料。E-mail：1328814114@qq.com。
基金资助:
贵州省教育厅工程研究中心项目（黔教合KY字(2017);贵州省科学技术基金（黔科合基础(2018);贵州省教育厅科技人才成长项目（黔教合KY字(2017)

Progress in preparation and application of core-shell structure nanocomposites with magnetism and fluorescence

Rong FU^1,²(),Chunlin YANG³,Yanyan HU^1,²,Meigui OU^1,²()

1. College of Materials and Metallurgy, University of Guizhou, Guiyang 550025, Guizhou, China
2. National Local Joint Engineering Laboratory for High Performance Metal Structure Materials and Manufacturing Technology, Guiyang 550025, Guizhou, China
3. College of Chemistry and Materials engineering, Guiyang University, Guiyang 550003, Guizhou, China

Received:2018-11-08 Online:2019-08-05 Published:2019-08-05
Contact: Meigui OU

摘要/Abstract

摘要：

核壳型磁性荧光纳米复合材料是材料领域的研究热点之一，该材料呈现了单一材料无法同时兼有的磁响应性及荧光特性，因此被广泛地应用于生物医疗领域，提高了疾病诊断的效率和准确率，改进了癌症治疗技术。本文简单介绍了具有核壳结构的磁性荧光纳米复合粒子的4种形成机理、一些比较常用的制备方法及其各自的优缺点；重点介绍了纳米复合粒子的表面修饰方法，主要包括表面钝化及表面功能化两大类；对核壳结构磁性荧光纳米复合材料在多模态分子影像、药物的靶向运输与可控释放、癌症的热疗法及光动力疗法等方面的应用作了阐述。最后展望了核壳型磁性荧光纳米复合材料未来的发展趋势，并针对研究过程中所存在的关键问题，提出了今后进一步研究的主要方向为寻找多功能材料的最佳组合及组装方式、优化整合表面修饰剂的性能和明确材料在体内的毒性及代谢情况等。

关键词: 磁性, 荧光, 制备方法, 表面修饰, 生物医学应用

Abstract:

Core-shell structured nanocomposites with magnetic and fluorescent properties are one of the research hotspots in the field of materials. The nanocomposites has not only magnetic responsiveness but also fluorescence, presenting characteristics that cannot be simultaneously achieved by a single material. Therefore, they have been widely used in the field of biological medicine and have improved the efficiency and accuracy of disease diagnosis to elevate the techniques of cancer treatment. This paper briefly introduced the four formation mechanisms of core-shell structured nanocomposites with magnetism and fluorescence and a few commonly used preparation methods. The advantages and disadvantages of these methods were analyzed respectively. The surface modification methods (surface passivation and surface functionalization) of nanoparticles were mainly introduced. Moreover, the application of core-shell magnetic and fluorescent nanocomposites in multimodal molecular imaging, targeted transport and controlled release of drugs, thermal therapy and photodynamic therapy for cancer were expounded. Finally, the developing trend of core-shell structured nanocomposites with magnetic and fluorescent was prospected. According to the main problems in the current research, the main research direction in the future was pointed out: finding the best combination and assembly method for multifunctional materials, optimizing and integrating the properties of surface modifier, identifying the toxicity and metabolism of materials in the body, etc.

Key words: magnetism, fluorescence, preparation method, surface modification, biomedical applications

中图分类号:

O482.31

付绒,杨春林,胡燕燕,欧梅桂. 核壳型磁性荧光纳米复合材料的制备及其应用研究进展[J]. 化工进展, 2019, 38(08): 3742-3755.

Rong FU,Chunlin YANG,Yanyan HU,Meigui OU. Progress in preparation and application of core-shell structure nanocomposites with magnetism and fluorescence[J]. Chemical Industry and Engineering Progress, 2019, 38(08): 3742-3755.

参考文献 22

1	ARVAND M , SANAYEEI M , HEMMATI S . Label-free electrochemical DNA biosensor for guanine and adenine by ds-DNA/poly(L-cysteine)/Fe₃O₄ nanoparticles-graphene oxide nanocomposite modified electrode[J]. Biosensors & Bioelectronics, 2017, 102:70-79.
2	CHA R, LI J , LIU Y , et al . Fe₃O₄ nanoparticles modified by CD-containing star polymer for MRI and drug delivery[J]. Colloids Surfaces B: Biointerfaces, 2017, 158: 213-221.
3	CHEN F , ZHAO W , ZHANG J , et al . Magnetic two-dimensional molecularly imprinted materials for the recognition and separation of proteins[J]. Physical Chemistry Chemical Physics, 2015, 18(2):718-725.
4	MU X , ZHANG F , KONG C , et al . EGFR-targeted delivery of DOX-loaded Fe₃O₄@polydopamine multifunctional nanocomposites for MRI and antitumor chemo-photothermal therapy[J]. International Journal of Nanomedicine, 2017, 12: 2899-2911.
5	RAYEGAN A , ALLAFCHIAN A , ABDOLHOSSEINI SARSARI I , et al . Synthesis and characterization of basil seed mucilage coated Fe₃O₄ magnetic nanoparticles as a drug carrier for the controlled delivery of cephalexin[J].International Journal of Biological Macromolecules, 2018, 113: 317-328.
6	RUI H , XING R J , XU Z C , et al . Synthesis, functionalization, and biomedical applications of multifunctional magnetic nanoparticles[J]. Advanced Materials, 2010, 22(25): 2729-2742.
7	SUN Y Q , DAI C M , ZHENG Y , et al . Binding effect of fluorescence labeled glycyrrhetinic acid with GA receptors in hepatocellular carcinoma cells[J]. Life Sciences, 2017, 188: 186-191.
8	WEI J R , CHEN H Y , ZHANG W , et al . Ratiometric fluorescence for sensitive and selective detection of mitoxantrone using a MIP@rQDs@SiO₂ fluorescence probe[J]. Sensors and Actuators B: Chemical, 2017, 244: 31-37.
9	李燕琴，牟兰，曾晞，等 . 对Fe~(3+)识别的2种香豆素-氧杂杯[3]芳烃荧光探针[J]. 贵州大学学报（自然科学版）, 2014, 31(3): 25-29.
	LI Yanqin , MU Lan , ZENG Xi , et al . Two oxacalix [3] arene-coumarin fluorescence probes and recognition for Fe³⁺ [J]. Journal of Guizhou University(Natural Science), 2014, 31(3): 25-29.
10	ZHOU L , WANG R , YAO C , et al . Single-band upconversion nanoprobes for multiplexed simultaneous in situ molecular mapping of cancer biomarkers[J]. Nature Communications, 2015, 6: 6938.
11	FUKUSHIMA S , FURUKAWA T , NIIOKA H , et al . Correlative near-infrared light and cathodoluminescence microscopy using Y₂O₃:Ln, Yb (Ln = Tm, Er) nanophosphors for multiscale, multicolour bioimaging[J]. Scientific Reports, 2016, 6: 25950.
12	YAN F Y , FAN K Q , BAI Z J , et al . Fluorescein applications as fluorescent probes for the detection of analytes[J]. Trac Trends in Analytical Chemistry, 2017, 97:15-35.
13	QIU H J , CUI B , ZHAO W W , et al . A novel microwave stimulus remote controlled anticancer drug release system based on Fe₃O₄@ ZnO@mGd₂O₃:Eu@P(NIPAm-co-MAA) multifunctional nanocarriers [J]. Journal of Materials Chemistry B, 2015, 3(34): 6919-6927.
14	LIU B , LI C , MA P, et al . Multifunctional NaYF₄：Yb, Er@mSiO₂@Fe₃O₄-PEG nanoparticles for UCL/MR bioimaging and magnetically targeted drug delivery[J]. Nanoscale, 2015, 7(5): 1839-1848.
15	ZHANG F , KONG X Q , LI Q , et al . Facile synthesis of CdTe@GdS fluorescent-magnetic nanoparticles for tumor-targeted dual-modal imaging[J]. Talanta, 2016, 148: 108-115.
16	WEN C Y , XIE H Y , ZHANG Z L , et al . Fluorescent/magnetic micro/nano-spheres based on quantum dots and/or magnetic nanoparticles: preparation, properties, and their applications in cancer studies[J]. Nanoscale, 2016, 8(25): 12406.
17	LEE D E, KOO H, SUN I C , et al . Multifunctional nanoparticles for multimodal imaging and theragnosis[J]. Chem.Soc.Rev., 2012, 41(7): 2656-2672.
18	KIM K D , BAE H J, KIM H T . Synthesis and characterization of titania-coated silica fine particles by semi-batch process[J]. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2003, 224(1/2/3): 119-126.
19	KIM K D , BAE H J, KIM H T . Synthesis and growth mechanism of TiO₂-coated SiO₂, fine particles[J]. Colloids & Surfaces A Physicochemical & Engineering Aspects, 2003, 221(1):163-173.
20	PENG H X , CUI B , LI L L , et al . A simple approach for the synthesis of bifunctional Fe₃O₄@Gd₂O₃:Eu³⁺ core-shell nanocomposites[J]. Journal of Alloys and Compounds, 2012, 531: 30-33.
21	陈顺，张俊俊，唐琪，等 . 磁性荧光纳米材料的制备与性能[J]. 化学学报, 2013, 71(3): 417-420.
	CHEN Shun , ZHANG Junjun , TANG Qi , et al . Preparation and properties of magnetic fluorescent nanomaterials[J]. Acta Chimica Sinica, 2013,71(3):417-420.
22	舒适 . 未改性SiO₂溶胶/聚丙烯酸酯复合乳胶粒的制备及其机理的研究[D]. 北京: 北京化工大学, 2010.
	SHU Shi . Preparation and mechanism of silica sol/polyacrylate composite latex using bare silica sol[D]. Beijing: Beijing University of Chemical Technology, 2010.

[1]	王少凡, 周颖, 郝康安, 黄安荣, 张如菊, 吴翀, 左晓玲. 具有pH响应性的自愈合蓝光水凝胶[J]. 化工进展, 2023, 42(9): 4837-4846.
[2]	张芳, 郭鹍鹏, 梁春平, 尤雪瑞, 张志超. 一种具有聚集诱导发光效应有机荧光小分子的设计合成及功能应用[J]. 化工进展, 2023, 42(6): 3097-3104.
[3]	徐国彬, 刘洪豪, 李洁, 郭家奇, 王琪. ZnO量子点水性喷墨荧光墨水制备及性能[J]. 化工进展, 2023, 42(6): 3114-3122.
[4]	冯琬淇, 哈尼夏·巴合提null, 葛雨璇, 赵俭波. 磁性PASP/PAM半互穿水凝胶的制备及性能[J]. 化工进展, 2023, 42(6): 3130-3137.
[5]	陈怡欣, 甄摇摇, 陈瑞浩, 吴继伟, 潘丽美, 姚翀, 罗杰, 卢春山, 丰枫, 王清涛, 张群峰, 李小年. 铂基纳米催化剂的制备及在加氢领域的进展[J]. 化工进展, 2023, 42(6): 2904-2915.
[6]	刘宇龙, 姚俊虎, 舒闯闯, 佘跃惠. 磁性Fe₃O₄纳米颗粒的生物合成及其在提高采收率中的应用[J]. 化工进展, 2023, 42(5): 2464-2474.
[7]	刘念, 陈葵, 武斌, 纪利俊, 吴艳阳, 韩金玲. 蛋黄-壳介孔磁性炭微球的制备及其对红霉素的高效吸附[J]. 化工进展, 2023, 42(5): 2724-2732.
[8]	张育新, 王灿, 舒文祥. 二氧化碳的还原及其利用研究进展[J]. 化工进展, 2023, 42(2): 944-956.
[9]	叶好, 胡平, 王策, 刘勇. 磁性纤维电磁波吸收剂研究进展[J]. 化工进展, 2023, 42(10): 5310-5321.
[10]	刘慧慧, 史笑飞, 王倩男, 刘锦博, 张静. pH响应性磁性介孔纳米载药系统的制备[J]. 化工进展, 2023, 42(10): 5390-5398.
[11]	杨凯璐, 陈明星, 王新亚, 张威, 肖长发. 染料废水处理用纳滤膜制备及改性研究进展[J]. 化工进展, 2023, 42(10): 5470-5486.
[12]	张英杰, 陆加越, 王方刚. 新型磁性树脂的合成及其在水中去除Cu(Ⅱ)的性能[J]. 化工进展, 2023, 42(10): 5558-5566.
[13]	蒋华义, 胡娟, 齐红媛, 游琰真, 王玉龙, 武哲. 磁性纳米粒子类型和质量浓度对微波热解含油污泥的影响[J]. 化工进展, 2022, 41(7): 3908-3914.
[14]	孙娜娜, 孙会娜, 沈莉莎, 苏瑞宇, 赵超. 磁性纳米颗粒-微波辐射对稠油O/W乳状液的协同破乳[J]. 化工进展, 2022, 41(6): 3127-3137.
[15]	马殿普, 李俊, 覃德清, 袁英杰, 潘飞, 符泽卫. 锡酸锌纳米材料的制备方法及应用研究进展[J]. 化工进展, 2022, 41(6): 3113-3126.

核壳型磁性荧光纳米复合材料的制备及其应用研究进展

Progress in preparation and application of core-shell structure nanocomposites with magnetism and fluorescence

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献 22

相关文章 15

编辑推荐

Metrics

本文评价