化工进展 ›› 2018, Vol. 37 ›› Issue (02): 592-598.DOI: 10.16085/j.issn.1000-6613.2017-0969

• 材料科学与技术 • 上一篇    下一篇

胶原蛋白基生物功能材料制备方法研究进展

王瑞瑞1,2, 王鸿儒1   

  1. 1 陕西科技大学轻工科学与工程学院, 中国轻工业皮革清洁生产重点实验室, 陕西 西安 710021;
    2 青海师范大学化学化工学院, 青海 西宁 810008
  • 收稿日期:2017-05-23 修回日期:2017-06-05 出版日期:2018-02-05 发布日期:2018-02-05
  • 通讯作者: 王鸿儒,博士,教授,研究方向为精细化学品的研究。
  • 作者简介:王瑞瑞(1980-),女,博士研究生,副教授。E-mail:wangruirui206@163.com。

Research progress in preparation methods of collagen based biomaterials

WANG Ruirui1,2, WANG Hongru1   

  1. 1 College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & Technology;Key Laboratory of Leather Cleaner Production, China National Light Industry, Xi'an 710021, Shaanxi, China;
    2 College of Chemistry and Chemical Engineering, Qinghai Normal University, Xining 810008, Qinghai, China
  • Received:2017-05-23 Revised:2017-06-05 Online:2018-02-05 Published:2018-02-05

摘要: 胶原蛋白具有强亲水性、优异的生物相容性、弱抗原性和易加工成型等独特的功能特性,已成为最有前途的绿色可再生材料之一。为了克服天然胶原蛋白材料热稳定性差、抗水性差、机械强度低、易酶解和易污染等缺陷,通常采用共价交联法、静电纺丝法、自组装法和相分离法等方法对胶原蛋白进行加工处理。本文首先介绍了胶原蛋白基生物功能材料的4种方法的制备原理,描述了4种方法的研究现状,指出了4种方法各自的优点和缺点,然后比较了4种方法的制备工艺、制备材料的结构和功能差异,最后展望了胶原蛋白基生物功能材料的研究前景。结果表明:胶原蛋白基生物功能材料作为清洁可再生材料在智能纳米药物载体、微型生物反应器、传感器、人造光俘获系统等领域具有广阔的应用前景。

关键词: 蛋白质, 胶原蛋白, 复合材料, 纳米结构, 制备, 生物工程

Abstract: Collagen has become one of the most promising green renewable functional materials due to its strong hydrophilicity, excellent biocompatibility, weak antigenicity, and easy to be processed. In order to overcome the disadvantages of natural collagen material, such as poor thermal stability, poor water resistance, low mechanical strength, easy enzymolysis and easy pollution, the collagen is usually processed by covalent cross-linking, electrospinning, self-assembly and phase separation. Firstly, the principle of four kinds of preparation methods was introduced. The research status of the four preparation methods was described. The advantages and disadvantages of the four methods were pointed out. Then, the preparation process, structure and function difference of the four methods were compared. Finally, the prospect of collagen based biomaterials was reviewed. Results showed that as a clean and renewable material, collagen based biomaterials have broad application prospects in the fields of micro bioreactor, sensor, mart drug delivery system, and artificial light harvesting system.

Key words: protein, collagen, composites, nanostructure, preparation, biological engineering

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