Cu2+/Tb2O3抗菌硅胶的制备及其抗菌行为

doi:10.16085/j.issn.1000-6613.2019-0215

摘要/Abstract

摘要：

以硅酸钠为硅源，运用溶胶-凝胶法制备出硅胶载体，采用液相浸渍法制备得到Cu²⁺/Tb₂O₃抗菌硅胶。选用扫描电子显微镜（SEM）、透射电子显微镜（TEM）、X射线衍射仪（XRD）和X射线光电子能谱仪（XPS）等对材料进行表征，结果表明：Cu²⁺/Tb₂O₃抗菌硅胶结构蓬松多孔，铜以CuO/Cu(OH)₂、铽以Tb₂O₃的形态负载于硅胶载体上。对样品进行最低抑菌浓度（MIC）和最小杀菌浓度（MBC）检测可知，添加稀土铽离子能有效提高抗菌硅胶的抑菌和杀菌性能。通过对材料的溶出液离子含量、比表面积和CuO晶粒尺寸研究发现，添加铽离子后材料中铜离子的溶出量从7.22mg/L增加到11.82mg/L，比表面积从115.5m²/g增加到129.3m²/g，CuO晶粒尺寸从107nm降低至76nm，并由此探讨铽离子对材料抗菌性能提升的作用机理。

关键词: 抗菌硅胶, 铜, 稀土, 抗菌机理

Abstract:

Silica gel was prepared by sol-gel method with Na₂SiO₃ as silica source. Cu²⁺/Tb₂O₃ antibacterial silica gel was prepared by dip and absorption. The materials was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) analyses. The results showed that Cu²⁺/Tb₂O₃ antibacterial silica gel structure was fluffy and porous. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration ( MBC ) of the samples were tested by antibacterial examination. The results indicated that the addition of rare earth terbium was advantageous to the bacteriostatic and bactericidal of antibacterial silica gel. The Ion release, surface area and CuO grain size of the antibacterial silica gel were investigated. The Ion release and surface area in the material increased from 7.22mg/L to 11.82mg/L and 115.5m²/g to 129.3m²/g after the addition of cerium ions, respectively. The CuO grain size in the material reduced from 107nm to 76nm after the addition of cerium ions. The relationship between rare earth terbium and the improvement of antibacterial properties was preliminarily analyzed.

Key words: antibacterial silica gel, copper, rare earth, antibacterial mechanism

中图分类号:

TB34

毛华明,张彬,崔帅,唐晓宁,杨苏娥,蒋先发. Cu²⁺/Tb₂O₃抗菌硅胶的制备及其抗菌行为[J]. 化工进展, 2019, 38(11): 5024-5032.

Huaming MAO,Bin ZHANG,Shuai CUI,Xiaoning TANG,Su’e YANG,Xianfa JIANG. Preparation and antibacterial method of Cu²⁺/Tb₂O₃ antibacterial silica gel[J]. Chemical Industry and Engineering Progress, 2019, 38(11): 5024-5032.

图/表 11

图1 Cu2+/Tb2O3抗菌硅胶的表面形貌

图2 Cu2+/Tb2O3抗菌硅胶XRD图

图3 Cu2+/Tb2O3抗菌硅胶XPS图

图4 Cu2+/Tb2O3抗菌硅胶对细菌生长曲线的影响

图5 抗菌硅胶对细菌生长曲线的影响

图6 不同浓度Cu2+/Tb2O3抗菌硅胶对大肠杆菌和金黄色葡萄球菌的MBC实验

图7 抗菌硅胶溶出液对细菌的杀菌作用

图8 抗菌硅胶溶出液中铜离子浓度

图9 抗菌硅胶的氮气吸附脱附等温线

图10 不同铽离子含量的载铜抗菌硅胶XRD图

图11 Cu2+/Tb2O3抗菌硅胶抗菌机理

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Cu²⁺/Tb₂O₃抗菌硅胶的制备及其抗菌行为

Preparation and antibacterial method of Cu²⁺/Tb₂O₃ antibacterial silica gel

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