关键词: 生物过程, 黄霉素, Streptomyces bambergiensis, 工业化发酵, 灰色预测模型, 预测

Abstract: A grey forecasting model was applied to the industrialization of flavomycin fermentation. The GM(1，8)，GM(1，1) and grey Verhulst forecasting models were established to predict the fed-batch fermentation process of flavomycin in 60m3 fermenter by Streptomyces bambergiensis，respectively. The average relative errors of three models were 15.322%，6.093% and 1.776%. The residual sums of square were 4.177 g2/L2，0.680 g2/L2 and 0.053 g2/L2. The result showed that grey Verhulst forecasting model could be employed to predict the industrial fermentation process of flavomycin more effectively.

Key words: bioprocess, flavomycin, Streptomyces bambergiensis, industrial fermentation, grey forecasting model, prediction