关键词: 两亲性超支化聚合物, 自组装, 药物载体, 合成

Abstract: In this paper，the research progress in amphiphilic hyperbranched polymers is overviewed. Synthetic methods of amphiphilic hyperbranched polymers are introduced，which covers the modification of end groups of the hyperbranched polymers with long chain alkyl and polyethylene glycol，and the polymerization of vinyl derivatives through free radical polymerization or ring-opening polymerization，using hyperbranched polymers as macroinitiator. Different structures of amphiphilic hyperbranched polymers have their unique properties in solution，such as core-shell unimolecule micelles and different micellar conformation aggregates. Moreover，the application of amphiphilic hyperbranched polymers，such as drug delivery carrier，material modification，and the encapsulation of dye molecules is also introduced. Then，the development trend of amphiphilic hyperbranched polymers is proposed. The preparation of special properties of amphiphilic hyperbranched polymers and the application of amphiphilic hyperbranched polymers in biological medicine should be the main focus in the development of amphiphilic hyperbranched polymers.

Key words: amphiphilic hyperbranched polymers, self-assembly, drug carrier, synthesis