化工进展 ›› 2023, Vol. 42 ›› Issue (7): 3695-3707.DOI: 10.16085/j.issn.1000-6613.2022-1685

• 生物与医药化工 • 上一篇    下一篇

木质素基控释材料及其在药物输送和肥料控释中的应用

关红玲(), 杨辉, 井红权, 刘玉琼, 谷守玉, 王好斌, 侯翠红()   

  1. 郑州大学化工学院,国家钙镁磷复合肥技术研究推广中心,教育部先进功能材料制造工程研究中心,河南 郑州 450001
  • 收稿日期:2022-09-13 修回日期:2022-11-10 出版日期:2023-07-15 发布日期:2023-08-14
  • 通讯作者: 侯翠红
  • 作者简介:关红玲(1988—),女,讲师,硕士生导师,研究方向为固废资源高效利用。E-mail:guanhongling@zzu.edu.cn
  • 基金资助:
    “十三五”国家重点研发计划(2018YFC1900204-04);国家自然科学基金青年项目(21808212);中国博士后基金面上项目(2019M652578);中原博士后创新人才计划

Lignin-based controlled release materials and application in drug delivery and fertilizer controlled-release

GUAN Hongling(), YANG Hui, JING Hongquan, LIU Yuqiong, GU Shouyu, WANG Haobin, HOU Cuihong()   

  1. National Center for Research & Popularization of Calcium, Magnesium, Phosphate and Compound Fertilizer Technology, Engineering Research Center of Advanced Functional Material Manufacturing, School of Chemical Engineering, Zhengzhou University, Zhengzhou 450001, Henan, China
  • Received:2022-09-13 Revised:2022-11-10 Online:2023-07-15 Published:2023-08-14
  • Contact: HOU Cuihong

摘要:

木质素作为储量仅次于纤维素的第二大生物质资源和重要的芳香族可再生资源,目前主要作为纤维素利用的副产物大量废弃,引发严重的资源浪费和环境污染。木质素资源开发和高值利用不仅可以减少直接燃烧造成的环境污染,而且对于实现生物质资源的全链条应用、提升生物质资源开发应用的可行性、可持续性和经济性具有重要意义。木质素结构中丰富的官能团和化学反应活性位点,及其作为生物质材料固有的可降解性和生物相容性,使其在生物医药和绿色可持续农业领域受到了广泛的关注和研究,也使其成为药物和绿色肥料提质增效和可控释放的理想载体。本文从木质素的结构特点出发,介绍了木质素及其改性材料在生物医药和绿色农业肥料中的应用基础,阐述了木质素在药物智能给送和肥料缓控释放领域的研究和应用进展,并分析了这些应用中存在的挑战以及未来值得关注的研究方向,以期为木质素资源化利用和缓控释材料的设计开发提供有益参考。

关键词: 木质素, 生物质, 智能控释, 药物输送, 绿色肥料

Abstract:

Lignin,known as the second largest biomass resource and important renewable aromatic resources, is currently mainly dumped as industrial waste of cellulose, which causes serious resources and environmental problems. The development and high value utilization of lignin resources can reduce the environmental pollution caused by direct incineration and exert important significance on realizing the circle economy of lignocellulose resources and improving the feasibility, economic efficiency and sustainability of the biomass utilization. The abundant active functional groups and chemical reactive sites in the molecular structure of lignin, as well as its inherent degradability and biocompatibility, have attracted extensive attention in biomedical and green sustainable agriculture. Based on the structural characteristics of lignin, this paper introduced the application basis of lignin and its modified materials in biomedicine and green agricultural fertilizers, expounded the latest research and application progress of lignin-based controlled release systems in drug delivery and green fertilizer, and analyzed the challenges and the research directions in the future, in order to provide useful reference for the resource development and high-value utilization of lignin.

Key words: lignin, biomass, controlled release, drug-delivery, green fertilizer

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