化工进展 ›› 2022, Vol. 41 ›› Issue (8): 4481-4490.DOI: 10.16085/j.issn.1000-6613.2021-2084

• 精细化工 • 上一篇    下一篇

硅烷化聚琥珀酰亚胺负载阿维菌素的制备与性能

苏少纯1(), 林成威1, 周新华1,3, 周红军1,2()   

  1. 1.仲恺农业工程学院化学化工学院,广东省普通高校农用绿色精细化学品重点实验室,广东 广州 510225
    2.植物健康创新研究院,广东省普通高校果蔬病虫害可持续防治重点实验室,广东 广州 510225
    3.岭南现代农业科学与技术广东省实验室茂名分中心,广东 茂名 525000
  • 收稿日期:2021-10-07 修回日期:2021-10-29 出版日期:2022-08-25 发布日期:2022-08-22
  • 通讯作者: 周红军
  • 作者简介:苏少纯(1996—),女,硕士研究生。E-mail:1469520680@qq.com
  • 基金资助:
    广东省农业产业技术体系共性关键技术(农业纳米)创新团队项目(2019KJ140);广州市科技计划(201903010011);广东省国际科技合作项目(2021A050530073);植物健康创新研究院科研项目(KA21031H105)

Preparation and properties of silanylated polysuccinimide-loaded avermectin

SU Shaochun1(), LIN Chengwei1, ZHOU Xinhua1,3, ZHOU Hongjun1,2()   

  1. 1.Key Laboratory of Agricultural Green Fine Chemicals of Guangdong Higher Education Institution, School of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, Guangdong, China
    2.Guangdong Provincial Key Laboratory of Sustainable Control of Fruit and Vegetable Diseases and Pests, Institute of Plant Health Innovation, Guangzhou 510225, Guangdong, China
    3.Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Maoming 525000, Guangdong, China
  • Received:2021-10-07 Revised:2021-10-29 Online:2022-08-25 Published:2022-08-22
  • Contact: ZHOU Hongjun

摘要:

为了减少农药的流失和降解,采用纳米材料与技术开发新型纳米剂型具有巨大潜力。本文以3-氨丙基三乙氧基硅烷(APTES)和丁二胺(DBA)为改性单体,采用胺解开环反应制备了硅烷化聚琥珀酰亚胺(PDSi),并通过自组装方式负载阿维菌素(AVM)得到AVM@PDSi纳米体系。结果表明,相较于原药,AVM@PDSi对叶面的黏附性明显提升,叶面滞留量提高了56.50%。PDSi材料具有良好的抗氧化活性,PDSi对1,1-二苯基-2-苦基肼(DPPH)自由基的清除率最高可达41.88%。AVM@PDSi具有良好的抗紫外性能,在相同的紫外强度照射下(Emax=365nm),AVM@PDSi半衰期比原药AVM延长了近一半。AVM@PDSi具有良好的缓释性能和pH响应释放性能,在pH=9时释放最快;在pH=7时,AVM@PDSi-3在72h后累积释放量为67%。研究表明,AVM@PDSi具有良好的储存稳定性,并且保留了AVM的杀虫活性。

关键词: 聚琥珀酰亚胺, 硅烷化, 纳米材料, 载体, 稳定性

Abstract:

In order to reduce the loss and degradation of pesticides, the nanomaterial and nanotechnologies have great potential to develop new nanoformulation. Silanylated polysuccinimide (PDSi) was prepared by the amine bond ring-opening reaction with 3-aminopropyl triethoxysilane and diaminobutane as functional monomers, which encapsulated avermectim (AVM) via self-assembly to form AVM@PDSi nanoparticles system. Compared with bare AVM, the leaves adhesion of AVM@PDSi is significantly improved with its leaf retention increased by 56.50%. Moreover, PDSi has good antioxidant activity with the maximum scavenging rate of 1,1-diphenyl-2-picrylhydrazide (DPPH) free radical being up to 41.88%. Under the same UV irradiation (Emax=365nm), the half-life of AVM (AVM@PDSi) is nearly half longer than bare AVM. Also, AVM@PDSi can intelligently control pesticide release by adjusting monomer ratio and pH, with the releasing rate for AVM@PDSi-3 being 67% after 72h and the fastest releasing at pH 9. More importantly, AVM@PDSi shows the good storage stability and retains the toxicity for insecticidal effect.

Key words: polysuccinimide, silanylated, nanomaterial, support, stability

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