酶催化超分子自组装及其在癌症诊疗中的应用研究进展

doi:10.16085/j.issn.1000-6613.2020-0076

摘要/Abstract

摘要：

自组装是自然界的普遍现象，也是构建超分子生物材料的有力工具。在众多方法中，酶催化超分子自组装具有优异的肿瘤靶向性及良好的生物安全性，是近年来癌症诊疗的一个重要新方向。针对这一趋势，本文简介了酶催化超分子自组装在细胞内、外的构建方法，详细总结了其在癌症诊疗中的应用。研究表明，酶催化超分子自组装材料在生物医学成像、选择性杀死癌细胞、药物递送和克服药物不良反应方面具有潜在的应用价值。提出了体内超分子组装体的微观形貌需要明确表征、构建自组装方法的酶范围需要扩展以及需要探索酶催化超分子自组装（EISA）与亚细胞器的相互作用等解决其发展中的问题的思路和方向，并对其在抗菌药物开发、免疫调节、创伤修复和组织再生领域的潜在应用作出了展望。

关键词: 酶催化, 多肽, 超分子自组装, 生物材料, 癌症诊疗

Abstract:

Self-assembly is a common phenomenon in nature and it is also a powerful tool for building supramolecular biomaterials. Among diverse anticancer strategies, enzyme-instructed supramolecular self-assembly has shown the advantages of tumor specificity and biocompatibility, thus emerging as one of the most attractive methodology for anticancer applications. According to this trend, this review summarizes the construction of intracellular/extracellular enzymatic-instructed supramolecular self-assembly and the potential applications in the field of cancer theranostics, ranging from biomedical imaging, cell fate control and targeted drug delivery. The idea for solving the problem is presented, such as to characterize clearly the microscopic morphology of supramolecular assemblies in vivo, to extend the range of enzymes used to construct the self-assembly method and to explore the interaction between EISA and subcellular organelle. At last, the author points out that foreseeable applications of enzyme-instructed supramolecular self-assembly may go beyond cancer and stem from antimicrobial agents, immuno-regulation, wound healing and tissue regeneration.

Key words: enzyme-trigger, peptide, supramolecular self-assembly, biomaterial, cancer theranostic

中图分类号:

TQ426

郝好, 姚庆鑫, 高远, 谢建军. 酶催化超分子自组装及其在癌症诊疗中的应用研究进展[J]. 化工进展, 2020, 39(11): 4568-4574.

Hao HAO, Qingxin YAO, Yuan GAO, Jianjun XIE. Application of enzyme-instructed supramolecular self-assembly in biomedicine[J]. Chemical Industry and Engineering Progress, 2020, 39(11): 4568-4574.

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