关键词: 血糖预测, 代谢模型, 吸收模型, 化工建模, 化学反应器

Abstract:

Diabetes mellitus is an endocrine and metabolic disease with high morbidity and complications, which so far cannot be healed. The patients not only have economic burden but also have poor quality of life. Those with serious illness also face long-term life threats. In recent years, the increasingly serious problem of diabetes has gradually become one of the major concerns of the society and the related fields. This article started from the introduction of human blood glucose regulation system, describing the causes of the two types of diabetes. From the chemical engineering point of view, the human body can be analogized to a control system for the blood glucose metabolism. The main mechanisms of the blood glucose control in diabetic patients and the key role of blood glucose prediction were pointed out. The paper introduced two main physiological models of blood glucose prediction in detail: the glucose-insulin metabolism model and the glucose absorption model. The important role of the chemical engineering modeling strategy in the construction of the absorption model was highlighted, and the advantages of the method as well as the deficiency of the existing models were analyzed. The suggestions on improved modeling approaches were further discussed based on the in vivo and in vitro experiments in recent years. Finally, the future work of blood glucose prediction was proposed. It is suggested to improve understanding themechanism and combine the blood glucose prediction model with the chemical engineering modeling strategy to better understand the effect of diet on blood glucose regulation. In addition, the long-term prediction model and the personalized model need to be improved.

Key words: blood glucose prediction, insulin kinetics model, glucose absorption model, chemical engineering modeling, chemical reactors