Chemical Industry and Engineering Progress ›› 2023, Vol. 42 ›› Issue (1): 373-385.DOI: 10.16085/j.issn.1000-6613.2022-0233

• Fine chemicals • Previous Articles     Next Articles

Progress on separation and purification for organic compounds by melt crystallization

QI Yabing1(), JIA Honglei2   

  1. 1.School of Chemistry and Chemical Engineering, Xi'an University of Architecture and Technology, Xi'an 710055, Shaanxi, China
    2.Quality Assurance Department, Zhejiang Xianfeng Technologies Co. , Ltd. , Taizhou 317000, Zhejiang, China
  • Received:2022-02-14 Revised:2022-04-08 Online:2023-02-20 Published:2023-01-25
  • Contact: QI Yabing

熔融结晶技术分离纯化有机化合物的研究进展

齐亚兵1(), 贾宏磊2   

  1. 1.西安建筑科技大学化学与化工学院,陕西 西安 710055
    2.浙江先锋科技股份有限公司质保部,浙江 台州 317000
  • 通讯作者: 齐亚兵
  • 作者简介:齐亚兵(1983—),男,博士,讲师,研究方向为结晶与分离技术。E-mail: qiyabing123@163.com
  • 基金资助:
    西安市碑林区科技计划(GX2134);西安建筑科技大学人才科技基金(RC1714);西安建筑科技大学青年科技基金(QN1509)

Abstract:

Different components have different freezing points. Melt crystallization utilizes the difference of freezing point to separate and purify the target components from the melt mixture through crystallization, washing and sweating on the basis of management of the energy flow. Due to the advantages of no solvent, low energy consumption, compact equipment and high pure product, melt crystallization is widely used in the field of separation and purification of organic compounds. The classification of melt crystallization are introduced firstly. Then the patterns of melt crystallizers are sketched. Besides, the research progress on separation and purification of organic isomers, organic chemical materials, daily necessities, food and medicine by melt crystallization is reviewed systematically. Furthermore, the existing problems in separation and purification of organic compounds by melt crystallization are analyzed. Finally, the development trends of separation and purification of organic compounds by melt crystallization are discussed. With the development of melt crystallization, the separation and purification of organic compounds by hybrid melt crystallization technologies aiming at raising product quality, decreasing energy consumption, and saving money, has been the main trend. The system engineering which contains melt crystallizers, processes, nucleation kinetics, growth kinetics, sweating mechanisms, and heat and mass transfer model will be the research hotspot of separation and purification of organic compounds by melt crystallization.

Key words: melt crystallization, separation, purification, organic compounds

摘要:

熔融结晶技术是利用被分离物质各组分间凝固点的差异,通过控制热量的输入和移出,使被分离组分从熔融液中结晶析出,经洗涤、发汗等操作,实现目标组分分离纯化的一种结晶技术。熔融结晶分离纯化技术由于具有不需要使用溶剂、能耗低、设备体积小、能得到高纯产品等优点,在有机化合物的分离纯化领域得到了广泛应用。本文简述了熔融结晶的方式,介绍了熔融结晶器的类型,综述了熔融结晶技术分离纯化有机同分异构体、有机化工原料、日用品、食品和药品的研究进展,分析了熔融结晶技术分离纯化有机化合物过程中存在的问题,展望了熔融结晶技术分离纯化有机化合物的发展方向。文中指出:随着熔融结晶技术的发展,以提高产品质量,减小能耗和降低成本为目的的耦合熔融结晶技术已成为熔融结晶技术发展的方向。以包含熔融结晶设备、工艺、晶体成核和生长动力学、发汗机理以及传热传质模型的系统工程将会成为熔融结晶分离纯化有机化合物的研究热点。

关键词: 熔融结晶, 分离, 纯化, 有机化合物

CLC Number: 

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