Abstract: The key role of tissue engineering scaffolds is the guidance of cell reproduction, cell growth, and the promotion of the tissue repair. Recently, much interest has been generated in the area of nano-fibrous scaffold in tissue engineering. It is mainly due to the nano-effects of nano-fibrous scaffold which improved the cell adherence, proliferation, migration and differentiation for various cell types. This study summarized the progress in the application of the nano-fibrous scaffold on the research of tissue engineering. Tissue engineering includes skin and wound dressing tissue engineering, blood vessel tissue engineering, neural tissue engineering, bone tissue engineering, cartilage tissue engineering. The application of the nano-fibrous scaffold in Controlled Drug Release is also introduced. It can be seen that the current nano-technology has not matured yet. The problem of nanofiber scaffolds in tissue engineering will be solved through the optimization of preparation process, introduction of genetic engineering and evaluation of safety performance of nano-materials and so on.

Key words: tissue engineering, nanofiber, scaffold

摘要： 组织工程支架的关键作用是起到引导细胞繁殖、生长，促进组织修复的一个过程。纳米纤维支架由于具有特殊的纳米效应，而更有利于细胞的黏附、增殖、功能化，因而被广泛应用于组织工程。本文分别介绍了纳米纤维支架在各类组织工程中应用，包括皮肤和创伤敷料组织工程、血管组织工程、神经组织工程、骨组织工程、软骨组织工程中应用的研究进展，同时介绍了纳米纤维支架药物控制释放中的应用。指出目前纳米技术还不成熟，需要从制备工艺的优化、基因工程的引入及纳米材料安全性能的科学评价等几方面解决纳米纤维支架在组织修复工程中面临的问题。

关键词: 组织工程, 纳米纤维, 支架