Abstract:   5-hydroxymethylfurfural（HMF）is a key intermediate for renewable fuels and fine chemicals，which can be synthesized from glucose，a typical hydrolysis product of lignocellulose. This review summarized the progress of dehydration of glucose to prepare 5-HMF，including formation mechanisms，reaction systems and catalysts. The reaction systems include ionic liquid，polar aprotic organic solvent and water contained biphasic solvent；catalysts include inorganic acid，salt，solid acid and alkali. The possible breakthrough in research was proposed to develop efficient catalysts，extraction agent，and efficient separation and purification technology.

Key words: glucose, isomerization, dehydration, 5-hydroxymethylfurfural, biphasic system, solid acid, glucose, isomerization, dehydration, 5-hydroxymethylfurfural, biphasic system, solid acid

摘要： 5-羟甲基糠醛(HMF)是重要的平台化合物，是制取生物液体燃料和其他许多重要精细化工品的前驱体。以木质纤维素为原料，通过水解得到葡萄糖，葡萄糖继续脱水可以得到5-羟甲基糠醛。本文对近年来利用葡萄糖制取5-羟甲基糠醛的研究进行了综述，重点阐述了葡萄糖脱水制取5-羟甲基糠醛过程的反应机理、反应体系和催化剂，并对未来可能取得突破的研究重点进行了评述与展望。

关键词: 葡萄糖, 异构化, 脱水, 5-羟甲基糠醛, 双相体系, 固体酸, 葡萄糖, 异构化, 脱水, 5-羟甲基糠醛, 双相体系, 固体酸