Abstract:

Pseudo-protein is a new synthetic biodegradable material. It takes amino acids as the basic structural unit. Unlike protein, pseudo-protein has other linking groups in addition to peptide bonds, which gives it not only the excellent properties of proteins, but also the good mechanical properties, thermal properties, adjustable physicochemical properties, excellent cytocompatibility, 3D microporous structure, etc. Therefore, pseudo-proteins can be effectively applied in carriers, wound healing, tissue engineering, etc. Firstly, this paper reviews the types of pseudo-proteins studied so far, including non-functional and functional pseudo-proteins, followed by a detailed description of the methods for the synthesis of pseudo-proteins by condensation, including solution polycondensation, interfacial polymerization, melt polycondensation and ring-opening polymerization, and then summarizes the applications of pseudo-protein biomaterials in drug carrier, gene carrier, tissue engineering and wound dressing. Finally, the future development of synthetic routes and applications of pseudo-protein biomaterials is prospected.

Key words: pseudo-protein, synthesis, polymers, carrier, tissue engineering

摘要：

伪蛋白是一种新型合成生物可降解材料，以氨基酸为基本结构单元，它与蛋白质不同的是除了含有肽键外，还含有其他连接基团，这种结构使其既具有蛋白质的优良特性，又具有良好的力学性能、热性能、可调节的物理化学性能以及优异的细胞相容性和3D微孔结构等性质，因此伪蛋白能够有效应用于载体、伤口愈合、组织工程等生物医药领域。本文首先综述了目前所研究的伪蛋白的类型，包括非功能性和功能性伪蛋白两类；之后详细阐述了缩聚合成伪蛋白的方法，包括溶液缩聚、界面聚合、熔融缩聚、开环聚合四种方法；接着归纳了伪蛋白生物材料在药物载体、基因载体、组织工程、创面敷料等方面的应用；最后，对伪蛋白生物材料在合成路线及应用方面未来的发展进行了探讨和展望。

关键词: 伪蛋白, 合成, 聚合物, 载体, 组织工程