Progress in preparation and application of core-shell structure nanocomposites with magnetism and fluorescence

doi:10.16085/j.issn.1000-6613.2018-2184

Abstract

Abstract:

Core-shell structured nanocomposites with magnetic and fluorescent properties are one of the research hotspots in the field of materials. The nanocomposites has not only magnetic responsiveness but also fluorescence, presenting characteristics that cannot be simultaneously achieved by a single material. Therefore, they have been widely used in the field of biological medicine and have improved the efficiency and accuracy of disease diagnosis to elevate the techniques of cancer treatment. This paper briefly introduced the four formation mechanisms of core-shell structured nanocomposites with magnetism and fluorescence and a few commonly used preparation methods. The advantages and disadvantages of these methods were analyzed respectively. The surface modification methods (surface passivation and surface functionalization) of nanoparticles were mainly introduced. Moreover, the application of core-shell magnetic and fluorescent nanocomposites in multimodal molecular imaging, targeted transport and controlled release of drugs, thermal therapy and photodynamic therapy for cancer were expounded. Finally, the developing trend of core-shell structured nanocomposites with magnetic and fluorescent was prospected. According to the main problems in the current research, the main research direction in the future was pointed out: finding the best combination and assembly method for multifunctional materials, optimizing and integrating the properties of surface modifier, identifying the toxicity and metabolism of materials in the body, etc.

Key words: magnetism, fluorescence, preparation method, surface modification, biomedical applications

摘要：

核壳型磁性荧光纳米复合材料是材料领域的研究热点之一，该材料呈现了单一材料无法同时兼有的磁响应性及荧光特性，因此被广泛地应用于生物医疗领域，提高了疾病诊断的效率和准确率，改进了癌症治疗技术。本文简单介绍了具有核壳结构的磁性荧光纳米复合粒子的4种形成机理、一些比较常用的制备方法及其各自的优缺点；重点介绍了纳米复合粒子的表面修饰方法，主要包括表面钝化及表面功能化两大类；对核壳结构磁性荧光纳米复合材料在多模态分子影像、药物的靶向运输与可控释放、癌症的热疗法及光动力疗法等方面的应用作了阐述。最后展望了核壳型磁性荧光纳米复合材料未来的发展趋势，并针对研究过程中所存在的关键问题，提出了今后进一步研究的主要方向为寻找多功能材料的最佳组合及组装方式、优化整合表面修饰剂的性能和明确材料在体内的毒性及代谢情况等。

关键词: 磁性, 荧光, 制备方法, 表面修饰, 生物医学应用

CLC Number:

O482.31

Rong FU,Chunlin YANG,Yanyan HU,Meigui OU. Progress in preparation and application of core-shell structure nanocomposites with magnetism and fluorescence[J]. Chemical Industry and Engineering Progress, 2019, 38(08): 3742-3755.

付绒,杨春林,胡燕燕,欧梅桂. 核壳型磁性荧光纳米复合材料的制备及其应用研究进展[J]. 化工进展, 2019, 38(08): 3742-3755.

References 22

1	ARVAND M , SANAYEEI M , HEMMATI S . Label-free electrochemical DNA biosensor for guanine and adenine by ds-DNA/poly(L-cysteine)/Fe₃O₄ nanoparticles-graphene oxide nanocomposite modified electrode[J]. Biosensors & Bioelectronics, 2017, 102:70-79.
2	CHA R, LI J , LIU Y , et al . Fe₃O₄ nanoparticles modified by CD-containing star polymer for MRI and drug delivery[J]. Colloids Surfaces B: Biointerfaces, 2017, 158: 213-221.
3	CHEN F , ZHAO W , ZHANG J , et al . Magnetic two-dimensional molecularly imprinted materials for the recognition and separation of proteins[J]. Physical Chemistry Chemical Physics, 2015, 18(2):718-725.
4	MU X , ZHANG F , KONG C , et al . EGFR-targeted delivery of DOX-loaded Fe₃O₄@polydopamine multifunctional nanocomposites for MRI and antitumor chemo-photothermal therapy[J]. International Journal of Nanomedicine, 2017, 12: 2899-2911.
5	RAYEGAN A , ALLAFCHIAN A , ABDOLHOSSEINI SARSARI I , et al . Synthesis and characterization of basil seed mucilage coated Fe₃O₄ magnetic nanoparticles as a drug carrier for the controlled delivery of cephalexin[J].International Journal of Biological Macromolecules, 2018, 113: 317-328.
6	RUI H , XING R J , XU Z C , et al . Synthesis, functionalization, and biomedical applications of multifunctional magnetic nanoparticles[J]. Advanced Materials, 2010, 22(25): 2729-2742.
7	SUN Y Q , DAI C M , ZHENG Y , et al . Binding effect of fluorescence labeled glycyrrhetinic acid with GA receptors in hepatocellular carcinoma cells[J]. Life Sciences, 2017, 188: 186-191.
8	WEI J R , CHEN H Y , ZHANG W , et al . Ratiometric fluorescence for sensitive and selective detection of mitoxantrone using a MIP@rQDs@SiO₂ fluorescence probe[J]. Sensors and Actuators B: Chemical, 2017, 244: 31-37.
9	李燕琴，牟兰，曾晞，等 . 对Fe~(3+)识别的2种香豆素-氧杂杯[3]芳烃荧光探针[J]. 贵州大学学报（自然科学版）, 2014, 31(3): 25-29.
	LI Yanqin , MU Lan , ZENG Xi , et al . Two oxacalix [3] arene-coumarin fluorescence probes and recognition for Fe³⁺ [J]. Journal of Guizhou University(Natural Science), 2014, 31(3): 25-29.
10	ZHOU L , WANG R , YAO C , et al . Single-band upconversion nanoprobes for multiplexed simultaneous in situ molecular mapping of cancer biomarkers[J]. Nature Communications, 2015, 6: 6938.
11	FUKUSHIMA S , FURUKAWA T , NIIOKA H , et al . Correlative near-infrared light and cathodoluminescence microscopy using Y₂O₃:Ln, Yb (Ln = Tm, Er) nanophosphors for multiscale, multicolour bioimaging[J]. Scientific Reports, 2016, 6: 25950.
12	YAN F Y , FAN K Q , BAI Z J , et al . Fluorescein applications as fluorescent probes for the detection of analytes[J]. Trac Trends in Analytical Chemistry, 2017, 97:15-35.
13	QIU H J , CUI B , ZHAO W W , et al . A novel microwave stimulus remote controlled anticancer drug release system based on Fe₃O₄@ ZnO@mGd₂O₃:Eu@P(NIPAm-co-MAA) multifunctional nanocarriers [J]. Journal of Materials Chemistry B, 2015, 3(34): 6919-6927.
14	LIU B , LI C , MA P, et al . Multifunctional NaYF₄：Yb, Er@mSiO₂@Fe₃O₄-PEG nanoparticles for UCL/MR bioimaging and magnetically targeted drug delivery[J]. Nanoscale, 2015, 7(5): 1839-1848.
15	ZHANG F , KONG X Q , LI Q , et al . Facile synthesis of CdTe@GdS fluorescent-magnetic nanoparticles for tumor-targeted dual-modal imaging[J]. Talanta, 2016, 148: 108-115.
16	WEN C Y , XIE H Y , ZHANG Z L , et al . Fluorescent/magnetic micro/nano-spheres based on quantum dots and/or magnetic nanoparticles: preparation, properties, and their applications in cancer studies[J]. Nanoscale, 2016, 8(25): 12406.
17	LEE D E, KOO H, SUN I C , et al . Multifunctional nanoparticles for multimodal imaging and theragnosis[J]. Chem.Soc.Rev., 2012, 41(7): 2656-2672.
18	KIM K D , BAE H J, KIM H T . Synthesis and characterization of titania-coated silica fine particles by semi-batch process[J]. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2003, 224(1/2/3): 119-126.
19	KIM K D , BAE H J, KIM H T . Synthesis and growth mechanism of TiO₂-coated SiO₂, fine particles[J]. Colloids & Surfaces A Physicochemical & Engineering Aspects, 2003, 221(1):163-173.
20	PENG H X , CUI B , LI L L , et al . A simple approach for the synthesis of bifunctional Fe₃O₄@Gd₂O₃:Eu³⁺ core-shell nanocomposites[J]. Journal of Alloys and Compounds, 2012, 531: 30-33.
21	陈顺，张俊俊，唐琪，等 . 磁性荧光纳米材料的制备与性能[J]. 化学学报, 2013, 71(3): 417-420.
	CHEN Shun , ZHANG Junjun , TANG Qi , et al . Preparation and properties of magnetic fluorescent nanomaterials[J]. Acta Chimica Sinica, 2013,71(3):417-420.
22	舒适 . 未改性SiO₂溶胶/聚丙烯酸酯复合乳胶粒的制备及其机理的研究[D]. 北京: 北京化工大学, 2010.
	SHU Shi . Preparation and mechanism of silica sol/polyacrylate composite latex using bare silica sol[D]. Beijing: Beijing University of Chemical Technology, 2010.

[1]	WANG Shaofan, ZHOU Ying, HAO Kang’an, HUANG Anrong, ZHANG Ruju, WU Chong, ZUO Xiaoling. Self-healing and blue-light hydrogel with pH responsiveness [J]. Chemical Industry and Engineering Progress, 2023, 42(9): 4837-4846.
[2]	LI Xuejia, LI Peng, LI Zhixia, JIN Dunshang, GUO Qiang, SONG Xufeng, SONG Peng, PENG Yuelian. Experimental comparation on anti-scaling and anti-wetting ability of hydrophilic and hydrophobic modified membranes [J]. Chemical Industry and Engineering Progress, 2023, 42(8): 4458-4464.
[3]	CHEN Yixin, ZHEN Yaoyao, CHEN Ruihao, WU Jiwei, PAN Limei, YAO Chong, LUO Jie, LU Chunshan, FENG Feng, WANG Qingtao, ZHANG Qunfeng, LI Xiaonian. Preparation of platinum based nanocatalysts and their recent progress in hydrogenation [J]. Chemical Industry and Engineering Progress, 2023, 42(6): 2904-2915.
[4]	XU Guobin, LIU Honghao, LI Jie, GUO Jiaqi, WANG Qi. Preparation and properties of ZnO QDs water-based inkjet fluorescent ink [J]. Chemical Industry and Engineering Progress, 2023, 42(6): 3114-3122.
[5]	FENG Wanqi, HANISHA·Bhahti , GE Yuxuan, ZHAO Jianbo. Preparation and properties of magnetic polyaspartic acid/polyacrylamide semi-interpenetrating hydrogel [J]. Chemical Industry and Engineering Progress, 2023, 42(6): 3130-3137.
[6]	ZHANG Yuxin, WANG Can, SHU Wenxiang. Research progress of carbon dioxide reduction and utilization [J]. Chemical Industry and Engineering Progress, 2023, 42(2): 944-956.
[7]	MA Dianpu, LI Jun, QIN Deqing, YUAN Yingjie, PAN Fei, FU Zewei. Research progress on the preparation method and application of zinc stannate nanomaterials [J]. Chemical Industry and Engineering Progress, 2022, 41(6): 3113-3126.
[8]	SHEN Qi, XUE Yuyuan, YANG Taowei, ZHANG Yan, LI Shengren. Research progress of lignin fluorescence [J]. Chemical Industry and Engineering Progress, 2022, 41(5): 2672-2685.
[9]	SONG Zihao, WANG Hongxin, DU Boyu, DUAN Qiuyang, LU Jinghong, JIANG Yinghui, CUI Sheng. Progress in preparation and performance application of polyimide aerogel [J]. Chemical Industry and Engineering Progress, 2022, 41(2): 816-826.
[10]	ZHANG Xinyu, ZHAO Zhenxia. Research progress of metal-organic framework-based phase-change materials for thermal energy storage [J]. Chemical Industry and Engineering Progress, 2022, 41(12): 6408-6418.
[11]	LIU Ruiqin, MENG Fanhui, WANG Liyan, ZHANG Peng, ZHANG Junfeng, TAN Yisheng, LI Zhong. Preparation of ordered mesoporous CuCoZr catalyst and its catalytic performance for syngas to ethanol and higher alcohols [J]. Chemical Industry and Engineering Progress, 2022, 41(11): 5870-5878.
[12]	WANG Xiqian, YIN Guoqiang, GUO Qingbing, HE Ming. Preparation and properties of FK/PLA nanofiber membrane modified with dopamine [J]. Chemical Industry and Engineering Progress, 2022, 41(1): 373-381.
[13]	SUN Jingchen, LIU Hailong, WANG Junfeng, HE Fachao. Flow visualization by PLIF technique and numerical modeling of mixing enhancement in stirred tank under electric fields [J]. Chemical Industry and Engineering Progress, 2021, 40(12): 6547-6556.
[14]	MA Guanxiang, YANG Ling, WANG Ting-jie. Surface modification of silica nanoparticles using polydopamine [J]. Chemical Industry and Engineering Progress, 2021, 40(12): 6729-6737.
[15]	GONG Xue, WANG Chengyao, ZHU Qunzhi. Research progress on preparation and application of microcapsule phase change materials [J]. Chemical Industry and Engineering Progress, 2021, 40(10): 5554-5576.