生物医用硅橡胶表面抗菌性能改造研究进展

doi:10.16085/j.issn.1000-6613.2018-0010

化工进展 ›› 2018, Vol. 37 ›› Issue (12): 4719-4725.DOI: 10.16085/j.issn.1000-6613.2018-0010

生物医用硅橡胶表面抗菌性能改造研究进展

李兆双¹, 李建芳², 刘鹤¹, 商士斌¹, 宋湛谦¹

1 中国林业科学研究院林产化学工业研究所;生物质化学利用国家工程实验室;国家林业局林产化学工程重点开放性实验室;江苏省生物质能源与材料重点实验室, 江苏南京 210042;
2 南京天翼专利代理有限责任公司, 江苏南京 210042

收稿日期:2018-01-02 修回日期:2018-03-22 出版日期:2018-12-05 发布日期:2018-12-05
通讯作者: 宋湛谦,研究员,博士生导师,中国工程院院士,从事松脂资源深加工利用研究。
作者简介:李兆双(1993),男,博士研究生,从事松香基高分子材料的研究。E-mail:lzs0829@163.com。
基金资助:
国家自然科学基金（31570562）及江苏省生物质能源与材料重点实验室基本科研业务费重点项目（JSBEM-S-201504）。

Research progress of surface modification of antibacterial performance of biomedical silicone rubber

LI Zhaoshuang¹, LI Jianfang², LIU He¹, SHANG Shibin¹, SONG Zhanqian¹

1 Institute of Chemical Industry of Forest Products, CAF;National Engineering Lab. for Biomass Chemical Utilization;Key and Open Lab. of Forest Chemical Engineering, SFA;Key Lab. of Biomass Energy and Material, Jiangsu Province, Nanjing 210042, Jiangsu, China;
2 Nanjing Tianyi Patent Agency Co., Ltd., Nanjing 210042, Jiangsu, China

Received:2018-01-02 Revised:2018-03-22 Online:2018-12-05 Published:2018-12-05

摘要/Abstract

摘要： 硅橡胶材料由于其优越的力学性能及良好的生物相容性，广泛应用于生物医学领域。但使用过程中易引发细菌感染，严重阻碍其临床应用，因此硅橡胶材料的抗菌性能改造成为国内外专家的研究热点。本文综述了近些年关于硅橡胶表面抗菌性能改造的研究成果，介绍了硅橡胶表面的亲水性改造以及不同种类的杀菌剂涂层对材料表面的改性可以有效地提升其抗菌性能。最后对硅橡胶表面抗菌性能改造研究进行展望，指出将亲水化合物与杀菌剂相结合制备出具有抗粘附及杀菌效果的双功能抗菌涂层对硅橡胶表面抗菌性能改造将成为下一步研究重点，同时采用天然可再生资源为原料开发抗菌涂层也将成为重要的研究方向之一。

关键词: 硅橡胶, 抗菌, 表面, 复合材料, 生物医学工程

Abstract: Silicone rubber materials are widely used in the biomedical field because of their superior mechanical properties and good biocompatibility. However, bacterial infection often occurs during their use, which seriously hinders their clinical application. Therefore, the improvement of the antibacterial properties of silicone rubber materials has become a research hotspot. This review summarizes and analyzes the antibacterial properties of the surface of silicone rubber. The hydrophilic transformation and the modification of the surface with different types of bactericide can effectively improve the antibacterial performance. Finally, the antibacterial properties of silicone rubber surface modification research prospects are expected. we point out that the combination of hydrophilic compounds and bactericide to prepare bifunctional antibacterial coating will become the focus of future research. Besides, the use of natural raw materials in the development of antimicrobial coatings will also become an important research direction.

Key words: silicone rubber, antibacterial, surface, composites, biomedical engineering

中图分类号:

TQ333.93

李兆双, 李建芳, 刘鹤, 商士斌, 宋湛谦. 生物医用硅橡胶表面抗菌性能改造研究进展[J]. 化工进展, 2018, 37(12): 4719-4725.

LI Zhaoshuang, LI Jianfang, LIU He, SHANG Shibin, SONG Zhanqian. Research progress of surface modification of antibacterial performance of biomedical silicone rubber[J]. Chemical Industry and Engineering Progress, 2018, 37(12): 4719-4725.

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生物医用硅橡胶表面抗菌性能改造研究进展

Research progress of surface modification of antibacterial performance of biomedical silicone rubber

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