化工进展 ›› 2016, Vol. 35 ›› Issue (01): 239-242.DOI: 10.16085/j.issn.1000-6613.2016.01.032

• 精细化工 • 上一篇    下一篇

4-溴代百里香酚的合成

卞云鹏1, 韩莉1, 罗金岳1, 徐徐1, 刘祖广2   

  1. 1 南京林业大学化学工程学院, 江苏 南京 210037;
    2 广西林产化学与工程重点实验室, 广西 南宁 530006
  • 收稿日期:2015-04-24 修回日期:2015-08-10 出版日期:2016-01-05 发布日期:2016-01-05
  • 通讯作者: 罗金岳,教授,研究方向为林产化学加工。E-mail:luojinyue@njfu.com.cn。
  • 作者简介:卞云鹏(1989-),男,硕士研究生。E-mail:743095391@qq.com。
  • 基金资助:
    国家自然科学基金(31470597)及广西林产化学与工程重点实验室重点项目(GXFC13-01)。

Synthesis process research of 4-bromothymol

BIAN Yunpeng1, HAN Li1, LUO Jinyue1, XU Xu1, LIU Zuguang2   

  1. 1 College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, Jiangsu, China;
    2 Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Nanning 530006, Guangxi, China
  • Received:2015-04-24 Revised:2015-08-10 Online:2016-01-05 Published:2016-01-05

摘要: 以百里香酚为原料,通过溴取代反应合成4-溴代百里香酚。采用FTIR、1H NMR等手段对产物进行了表征,确定了产物结构。探讨了溶剂种类、溴代剂种类和用量、反应时间、反应温度和微波加热功率对产物得率的影响,得到适宜的工艺条件为:以N-溴代丁二酰亚胺为溴代剂,n(百里香酚):n(N-溴代丁二酰亚胺)=1:1.5,溶剂为乙酸,反应温度为20℃,反应时间15min,微波反应功率500W。在上述条件下,4-溴代百里香酚的得率为65.1%。

关键词: 4-溴代百里香酚, N-溴代丁二酰亚胺, 百里香酚, 辐射, 优化, 合成

Abstract: 4-bromothymol was synthesized by the bromination reaction using thymol as starting material. The product was characterized by FTIR, 1H NMR and the product structure was determined. The effects of different solvent, the type and amount of bromine generation agent, the reaction time, the reaction temperature and microwave heating power on the yield of product were discussed. The N-bromobutanimide was used as bromine generation agent and the solvent was ethanol acetic acid. The optimum conditions were:n(thymol):n(N-bromobutanimide)=1:1.5. The reaction temperature was 20℃, the reaction time was 15min, the microwave heating power was 500W. Under the above optimal conditions, 4-bromothymol yield was 65.1%.

Key words: 4-bromothymol, N-bromobutanimide, thymol, radiation, optimization, synthesis

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