关键词: 4-溴代百里香酚, N-溴代丁二酰亚胺, 百里香酚, 辐射, 优化, 合成

Abstract: 4-bromothymol was synthesized by the bromination reaction using thymol as starting material. The product was characterized by FTIR, ¹H NMR and the product structure was determined. The effects of different solvent, the type and amount of bromine generation agent, the reaction time, the reaction temperature and microwave heating power on the yield of product were discussed. The N-bromobutanimide was used as bromine generation agent and the solvent was ethanol acetic acid. The optimum conditions were:n(thymol):n(N-bromobutanimide)=1:1.5. The reaction temperature was 20℃, the reaction time was 15min, the microwave heating power was 500W. Under the above optimal conditions, 4-bromothymol yield was 65.1%.

Key words: 4-bromothymol, N-bromobutanimide, thymol, radiation, optimization, synthesis