关键词: Pd催化, 氟化, 对映选择性氟化

Abstract: The study on palladium-catalyzed reactions is one of the frontier areas in organic synthesis chemistry. Palladium compounds，which show high activity and selectivity as catalysts in the fluorination reactions，have attracted more attentions. The main progress made in the field of palladium-catalyzed fluorination during the last decade is reviewed. Moreover，efforts in studying Pd-catalyzed organic transformations have been focused on nucleophilic fluorination，electrophilic fluorination and asymmetric reaction. In addition，the reaction conditions，selectivity，yields and mechanisms are discussed and summarized. The researches on palladium catalysts for the synthesis of aryl fluorides are also reviewed，especially，the catalytic mechanism，the reaction conditions and ligand. The reaction system for the synthesis of alkyl fluorides is briefly discussed. Moreover，the outlook for further prospect of palladium-catalyzed fluorination is given in this paper. The further research work should be focused on the investigation of reaction mechanism and the selection of catalyst ligand.

Key words: palladium-catalyzed, fluorination, enantioselection fluorination