溶液结晶过程强化

doi:10.16085/j.issn.1000-6613.2023-1146

摘要/Abstract

摘要：

溶液结晶是化学工业中最重要的产品分离、纯化和功能化技术之一，广泛应用于医药、食品、精细化工等领域。溶液结晶中晶体的成核和生长过程将决定最终晶体产品的晶型、晶习、粒度、纯度等关键质量指标。因此，对溶液结晶过程，尤其是晶体成核和生长过程进行强化既有利于提高过程效率，也有助于满足晶体产品不同的性能需求。本文围绕晶体成核和生长强化这一关键问题，从受限空间、物理场、添加剂和模板剂等方面系统综述了溶液结晶中的过程强化策略。探讨了各种过程强化策略的优点和局限性，并总结了溶液结晶过程强化策略的主要研究重点和发展前景。

关键词: 结晶, 成核, 生长, 粒度分布, 过程强化

Abstract:

Solution crystallization is one of the most important product separation, purification and functionalization techniques in chemical industry, which is widely used in pharmaceutical, food, fine chemicals and other fields. The nucleation and growth process of crystals in solution crystallization will determine the key physicochemical properties such as crystal form, crystal habit, particle size and purity of the final crystal products. Therefore, process intensification of solution crystallization, especially crystal nucleation and growth process, can help to improve the process efficiency and meet the different performance requirements of crystal products. In this paper, process intensification strategies for nucleation and crystal growth in solution crystallization are systematically reviewed, including the technologies of confined space, physical fields, additives and template agents. The advantages and limitations of various process intensification strategies are discussed, and the main research focuses and development prospects of solution crystallization process intensification strategies are summarized.

Key words: crystallization, nucleation, growth, particle size distribution, process intensification

中图分类号:

TQ026.5

冯瑶光, 陈奎, 赵佳伟, 王娜, 王霆, 黄欣, 周丽娜, 郝红勋. 溶液结晶过程强化[J]. 化工进展, 2024, 43(1): 87-99.

FENG Yaoguang, CHEN Kui, ZHAO Jiawei, WANG Na, WANG Ting, HUANG Xin, ZHOU Lina, HAO Hongxun. Process intensification of solution crystallization[J]. Chemical Industry and Engineering Progress, 2024, 43(1): 87-99.

图/表 17

参考文献 114

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溶液结晶物系	存在问题	强化方法	强化效果	文献来源
甘氨酸	传统结晶的时间长达数小时	微乳液	结晶时间缩短至几分钟，实现对形状、尺寸和尺寸分布的控制	[33]
颜料红146	传统结晶的晶体尺寸较大	微乳液	粒径小一个数量级且更均匀，满足喷墨印刷要求	[34]
度鲁特韦钠	管式结晶的晶体尺寸过大和晶体聚集导致堵塞	微流体耦合超声	与市售产品相比，中值粒径和粒径分布分别减少了30%和60%	[39]
溶菌酶	晶体成核和生长速率较慢	微流体耦合超声	成核速率增加三倍，晶体尺寸更均匀	[40]

溶液结晶物系	存在问题	强化方法	强化效果	文献来源
甘氨酸	传统结晶的时间长达数小时	微乳液	结晶时间缩短至几分钟，实现对形状、尺寸和尺寸分布的控制	[33]
颜料红146	传统结晶的晶体尺寸较大	微乳液	粒径小一个数量级且更均匀，满足喷墨印刷要求	[34]
度鲁特韦钠	管式结晶的晶体尺寸过大和晶体聚集导致堵塞	微流体耦合超声	与市售产品相比，中值粒径和粒径分布分别减少了30%和60%	[39]
溶菌酶	晶体成核和生长速率较慢	微流体耦合超声	成核速率增加三倍，晶体尺寸更均匀	[40]

溶液结晶物系	存在问题	强化方法	强化效果	文献来源
溶菌酶	晶体成核和生长速率较慢，传统结晶的晶体粒径分布较宽	超声场	在较低浓度下的成核诱导期缩短到1/10，晶体粒径分布更窄，形貌更均匀	[62]
氨苄西林	传统结晶形成针状晶体，导致压片困难	超声场	形成片状晶体，成核诱导时间缩短到1/8，产率提高约4.75倍	[65]
溶菌酶	晶体成核和生长速率较慢	电场	成核速率增加，结晶产率提高约2.6倍	[72]
溶菌酶	晶体成核和生长速率较慢	激光	结晶时间缩短到1/20	[86]

溶液结晶物系	存在问题	强化方法	强化效果	文献来源
溶菌酶	晶体成核和生长速率较慢，传统结晶的晶体粒径分布较宽	超声场	在较低浓度下的成核诱导期缩短到1/10，晶体粒径分布更窄，形貌更均匀	[62]
氨苄西林	传统结晶形成针状晶体，导致压片困难	超声场	形成片状晶体，成核诱导时间缩短到1/8，产率提高约4.75倍	[65]
溶菌酶	晶体成核和生长速率较慢	电场	成核速率增加，结晶产率提高约2.6倍	[72]
溶菌酶	晶体成核和生长速率较慢	激光	结晶时间缩短到1/20	[86]

溶液结晶物系	存在问题	添加剂	强化效果	文献来源
胰岛素	晶体成核和生长缓慢，结晶控制困难	氨基酸	晶体成核概率提高4～7倍	[96]
溶菌酶	晶体成核和生长速率较慢	离子液体	成核速率提高1～3倍	[97]
溶菌酶	晶体成核和生长速率较慢	动物DNA	晶体成核概率提高2.8～33倍	[98]