氧化石墨烯/聚丙烯酸基导电黏附凝胶的制备与性能

doi:10.16085/j.issn.1000-6613.2023-0323

摘要/Abstract

摘要：

现有导电凝胶材料在实际使用时存在诸多缺陷，因此设计出一种兼具高强度、高黏附性和高导电性的凝胶材料具有重要的应用意义。本文以丙烯酸（AAc）和丙烯酸-N-羟基琥珀酰亚胺酯（AAc-NHS ester）为基体，聚乙二醇二丙烯酸酯（PEGDA）为交联剂，引入氧化石墨烯（GO）作为增效成分，通过光引发一步聚合法制备了复合凝胶材料（PAA-NHS/GO）。GO的引入提高了体系的交联度，增强了凝胶的稳定性并赋予了凝胶高导电特性。PAA-NHS/GO的拉伸强度、断裂伸长率、电导率分别可达0.336MPa、302.6%和0.93S/m。复合凝胶的功能基团能与组织表面产生强黏附效果，黏附强度超过40kPa，同时还具备高生物安全性和优异的生物相容性。在外力作用下，复合凝胶表现出稳定的应变传感特性。而在用于心电信号监测时，复合凝胶的灵敏度高，并可实现稳定清晰的信号传输。PAA-NHS/GO作为新型导电黏附凝胶，有望用于柔性可穿戴、生物传感、电子皮肤等领域。

关键词: 氧化石墨烯, 聚丙烯酸, 凝胶, 导电, 黏附

Abstract:

Current conductive hydrogel materials have many shortcomings in practical application, and thus it is of great significance to design and prepare a hydrogel with high strength, high adhesion and high conductivity. Graphene oxide (GO) was used as synergistic component and introduced into the hydrogel matrix fabricated by N-hydroxysuccinimide (NHS) grafted polyacrylic acid (PAA). Subsequently, PAA-NHS/GO composite hydrogels were prepared by a photoinitiated one-step polymerization method. The introduction of GO improved the crosslinking degree of the hydrogel system, increased the stability of the hydrogel and endowed it with high conductivity. The tensile strength, elongation at break and conductivity of PAA-NHS/GO could reach 0.336MPa, 302.6% and 0.93S/m, respectively. The functional groups of the composite hydrogel could generate strong adhesion effect with the tissue surface, and the adhesion strength could reach to more than 40kPa. Additionally, PAA-NHS/GO possessed high biosafety and excellent biocompatibility. The composite hydrogel exhibited the ability of stable deformation sensing under external force. When used for electrocardiosignal (ECG) signal monitoring, the composite hydrogel showed high sensitivity and could achieve stable and clear signal transmission. As a novel conductive and adhesive hydrogel, PAA-NHS/GO was expected to be used in the fields of flexible wearable devices, biosensor and electronic skin.

Key words: graphene oxide, polyacrylic acid, hydrogel, conductive, adhesive

中图分类号:

王岩森, 侯丹丹, 李长金, 祁丽亚, 王春堯, 郭敏, 王颖. 氧化石墨烯/聚丙烯酸基导电黏附凝胶的制备与性能[J]. 化工进展, 2024, 43(2): 1022-1032.

WANG Yansen, HOU Dandan, LI Changjin, QI Liya, WANG Chunyao, GUO Min, WANG Ying. Preparation and properties of graphene oxide/polyacrylic acid conductive and adhesive hydrogels[J]. Chemical Industry and Engineering Progress, 2024, 43(2): 1022-1032.

图/表 12

图1 PAA-NHS/GO复合凝胶的制备过程及结构示意图

图2 凝胶内部相互作用及GO、PAA-NHS、PAA-NHS/GO的FTIR图谱

图3 凝胶材料的宏观照片和SEM照片

图4 凝胶材料的溶胀性能测试

图5 不同凝胶材料的热学性能

图6 不同凝胶材料的力学性能

图7 复合凝胶的宏观黏附效果和黏附机理

图8 不同凝胶的黏附强度及黏附稳定性

图9 不同凝胶的电导率测试

图10 复合凝胶中丙烯酸残留测试

图11 复合凝胶的细胞毒性评价及细胞在材料表面生长情况

图12 复合凝胶在不同形变下的相对电阻变化及用于心电信号监测

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