静电纺丝乙酸纤维素在生物医药领域的应用研究进展

doi:10.16085/j.issn.1000-6613.2017-0308

摘要/Abstract

摘要： 乙酸纤维素具有良好的溶解性、生物相容性和生物降解性，常用来替代纤维素作为静电纺丝的基体材料，广泛应用于生物医药、电化学、过滤膜等领域。本文介绍了通过物理共混、同轴电纺、层层自组装等多种手段将酶、药物、细胞等有效成分搭载于乙酸纤维素纤维中，获得功能化的改性乙酸纤维素电纺纤维的方法。阐明了电纺乙酸纤维素纤维因具有较大的孔隙率、比表面积、特殊的三维网络结构，能够有效绑定生物基团，实现药物的控释，促进细胞的黏附与增长的显著优势。综述了电纺乙酸纤维素纤维在酶的固定化平台、药物的包载与缓释、组织工程、生物传感器、抗菌膜、创口敷料等领域的应用。明晰了其在生物医药领域应用的科学价值及现实意义，指出了其在科学研究及工业化生产的中难点，并对其发展方向进行了展望。

关键词: 静电纺丝, 乙酸纤维素, 生物医学工程

Abstract: For its good solubility in organic solvents,biocompatibility and biodegradability,cellulose acetate is usually used as the substitutive product of cellulose,and widely applied in the fields of biomedicine,electrochemistry,filtration membrane,etc.This paper describes the method to obtain the functional electrospun cellulose acetate fiber carrying the active ingredient such as enzyme,drug,and cell by using physical blend,coaxial electrospinning,layer-by-layer self-assembly technique,etc.The paper also reveals that the electrospun cellulose acetate fiber has significant advantages for its high porosity,specific surface area and three-dimensional net structure.So it can effectively bind biological groups,control the drug release and promote cell adhesion and growth.Meanwhile,the applications on enzyme immobilization,drug delivery and sustained release,tissue engineering,biosensors,antibacterial mats and wound dressings are reviewed.The paper aims to clarify the scientific value and practical significance of the application of electrospinning cellulose acetate,point out the difficulties in scientific research and industrial production,and prospect the fibers development direction.

Key words: electrospinning, cellulose acetate, biomedical engineering

中图分类号:

TQ342⁺.9

薛海龙, 李莉莉, 张春玲, 张万喜, 侯甲子, 程岩. 静电纺丝乙酸纤维素在生物医药领域的应用研究进展[J]. 化工进展, 2017, 36(S1): 297-302.

XUE Hailong, LI Lili, ZHANG Chunling, ZHANG Wanxi, HOU Jiazi, CHENG Yan. Progress of the biomedical application of cellulose acetate electrospun fibers[J]. Chemical Industry and Engineering Progress, 2017, 36(S1): 297-302.

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