关键词: 5-苯基-7-氯-1, 3-二氢-2H-1, 4-苯并二氮杂(艹卓)-2-酮, 2-氨基-5氯-二苯甲酮, 微波辐射, 酰化, 环合

Abstract: In this paper,2-amino-5-chloro-benzophenone and chloroacetyl chloride were used as starting materials to synthesize 2-chloroacetylamino-5-chloro-benzophenone by chloroacetylation and then reacted with hexamethylenetetramine under microwave irradiation by Delépine reaction and the ketamine condensation reaction to give 5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one. The influence of the main reaction conditions on the yield of the product was studied by single factor experiment. The optimum reaction conditions were determined as follows:reaction temperature 100℃, n(2-chloroacetylamino-5-chloro-benzophenone):n(hexamethylenetetramine)=1:2.0, reaction time 50min, 2mL of 36% acetic acid,25mL of anhydrous ethanol and the yield of the cyclization reaction reached 89.6% under the optimal reaction conditions, the total yield was 84.8%, The experimental reproducibility is better. The products were characterized by melting point, IR and ¹HNMR. The results showed that the synthesized product was the target product.

Key words: 5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepine-2-one, 2-amino-5-chloro-benzophenone, microwave irradiation, chloroacetylation, cyclization