Chemical Industry and Engineering Progress ›› 2021, Vol. 40 ›› Issue (4): 2251-2257.DOI: 10.16085/j.issn.1000-6613.2020-1653
• Biochemical and pharmaceutical engineering • Previous Articles Next Articles
LI Ling1(), YU Yong1, HU Yonghong2()
Received:
2020-08-18
Online:
2021-04-14
Published:
2021-04-05
Contact:
HU Yonghong
通讯作者:
胡永红
作者简介:
李玲(1986—),女,讲师,研究方向为发酵工程制药。E-mail:基金资助:
CLC Number:
LI Ling, YU Yong, HU Yonghong. Research progress in production of lipstatinfermentation[J]. Chemical Industry and Engineering Progress, 2021, 40(4): 2251-2257.
李玲, 于泳, 胡永红. 发酵法生产利普司他汀的研究进展[J]. 化工进展, 2021, 40(4): 2251-2257.
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URL: https://hgjz.cip.com.cn/EN/10.16085/j.issn.1000-6613.2020-1653
菌株 | 育种、优化方法 | 效价 /mg·L-1 | 研究团队 | 年份 |
---|---|---|---|---|
S.toxytricini NRRL 15443 | 6.23 | Paul等[ | 1985 | |
S.toxytricini NRRL 15443 | 43.17 | Weibel等[ | 1987 | |
S.toxytricini CCM 7349 | 70L发酵罐补料发酵,约34h补加亚油酸、L-亮氨酸混合溶液 | 3290 | Varga等[ | 2007 |
S.toxytricini | 补料添加0.3%亚油酸、1%豆油 | 4773 | Gasparic等[ | 2007 |
S.toxytricini | 培养20h后补加亚油酸和L-亮氨酸,控制亚油酸体积分数0.3%~0.5% | 4400 | Fujs等[ | 2010 |
S.toxytricini NRRL 15443 | Plackett-Burman法优化发酵种子、发酵培养基 | 1980 | Kumar等[ | 2011 |
S.toxytricini ATCC 19813 | UV和NTG联合诱变,全因子试验设计优化发酵培养条件,大豆粉35g/L和豆油25g/L | 3290 | Luthra等[ | 2013 |
S.toxytricini NRRL B-5426 | 调节碳氮比例、补充金属辅因子、维生素、TCA循环中间产物,有机酸和NADH | 2242.63 | Kumar等[ | 2016 |
S.toxytricini NRRL B-5426 | 紫外、甲磺酸乙酯、甲基甲烷磺酸盐和NTG复合诱变结合前体物添加 | 2387 | Kumar等[ | 2018 |
S.toxytricini srn7 | 添加前体:亚油酸0.02~0.1mg/g,油酸0.02~0.15mg/g,L-亮氨酸1.5%,大豆粉10% | 5886 | Khushboo等[ | 2020 |
S.toxytricini HCCB-2 | 紫外和微波复合诱变,培养条件优化 | 663 | 王栋海[ | 2004 |
S.toxytricini XC-lp-69 | 紫外和微波复合诱变,补料发酵 | 1400 | 韩俊如等[ | 2006 |
S.toxytricini SIPI-UN-21 | 紫外、NTG复合诱变,培养条件优化 | 3.25倍 | 黄娟等[ | 2006 |
S.toxytricini | 正交设计优化发酵培养基,补料油酸/辛酸补料、L-亮氨酸和豆油 | 1.2倍 | 王永青[ | 2013 |
S.toxytricini zjut011 | 正交试验法,添加前体L-亮氨酸,首次发现二价阳离子Mg2+、Co2+和Zn2+对提高效价有显著作用 | 4208 | Zhu等[ | 2014 |
S.toxytricini FIM-1015 | 考察溶氧和剪切力因素,10L发酵罐补料发酵 | 6446 | 孙菲[ | 2014 |
S.toxytricini LIPS-352 | 紫外-微波复合诱变,添加前体葵花籽油,Box-Behnken设计优化 | 8122.9 | 刘顺娜等[ | 2017 |
S.toxytricini FIM-17-16 | 发酵条件优化 | 9667 | 陈洲琴等[ | 2020 |
菌株 | 育种、优化方法 | 效价 /mg·L-1 | 研究团队 | 年份 |
---|---|---|---|---|
S.toxytricini NRRL 15443 | 6.23 | Paul等[ | 1985 | |
S.toxytricini NRRL 15443 | 43.17 | Weibel等[ | 1987 | |
S.toxytricini CCM 7349 | 70L发酵罐补料发酵,约34h补加亚油酸、L-亮氨酸混合溶液 | 3290 | Varga等[ | 2007 |
S.toxytricini | 补料添加0.3%亚油酸、1%豆油 | 4773 | Gasparic等[ | 2007 |
S.toxytricini | 培养20h后补加亚油酸和L-亮氨酸,控制亚油酸体积分数0.3%~0.5% | 4400 | Fujs等[ | 2010 |
S.toxytricini NRRL 15443 | Plackett-Burman法优化发酵种子、发酵培养基 | 1980 | Kumar等[ | 2011 |
S.toxytricini ATCC 19813 | UV和NTG联合诱变,全因子试验设计优化发酵培养条件,大豆粉35g/L和豆油25g/L | 3290 | Luthra等[ | 2013 |
S.toxytricini NRRL B-5426 | 调节碳氮比例、补充金属辅因子、维生素、TCA循环中间产物,有机酸和NADH | 2242.63 | Kumar等[ | 2016 |
S.toxytricini NRRL B-5426 | 紫外、甲磺酸乙酯、甲基甲烷磺酸盐和NTG复合诱变结合前体物添加 | 2387 | Kumar等[ | 2018 |
S.toxytricini srn7 | 添加前体:亚油酸0.02~0.1mg/g,油酸0.02~0.15mg/g,L-亮氨酸1.5%,大豆粉10% | 5886 | Khushboo等[ | 2020 |
S.toxytricini HCCB-2 | 紫外和微波复合诱变,培养条件优化 | 663 | 王栋海[ | 2004 |
S.toxytricini XC-lp-69 | 紫外和微波复合诱变,补料发酵 | 1400 | 韩俊如等[ | 2006 |
S.toxytricini SIPI-UN-21 | 紫外、NTG复合诱变,培养条件优化 | 3.25倍 | 黄娟等[ | 2006 |
S.toxytricini | 正交设计优化发酵培养基,补料油酸/辛酸补料、L-亮氨酸和豆油 | 1.2倍 | 王永青[ | 2013 |
S.toxytricini zjut011 | 正交试验法,添加前体L-亮氨酸,首次发现二价阳离子Mg2+、Co2+和Zn2+对提高效价有显著作用 | 4208 | Zhu等[ | 2014 |
S.toxytricini FIM-1015 | 考察溶氧和剪切力因素,10L发酵罐补料发酵 | 6446 | 孙菲[ | 2014 |
S.toxytricini LIPS-352 | 紫外-微波复合诱变,添加前体葵花籽油,Box-Behnken设计优化 | 8122.9 | 刘顺娜等[ | 2017 |
S.toxytricini FIM-17-16 | 发酵条件优化 | 9667 | 陈洲琴等[ | 2020 |
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