The fabrication of molecularly imprinted electochemical sensor and its application in protein detection

doi:10.16085/j.issn.1000-6613.2016-2080

Abstract

Abstract: Molecular imprinting electrochemical sensor is a combination of molecular imprinting technology and analytical sensor technology,which possess the advantages of molecular imprinting technique,avoids the disadvantages of traditional sensors,improves the electrochemical sensor sensitivity and selectivity,and shortens the response time.Because of its simple design,economical and practical advantages,this technology becomes popular in more and more areas.In this paper,five commonly used preparation methods for molecular imprinting sensors include coating method,in situ polymerization method,electric polymerization method,sol-gel method and self-assembly method are introduced,and the application of these five methods are discussed.The application of four molecular imprinted sensors (MIPs capacitance/impedance type,MIPs conductivity type,MIPs potential type,MIPs current type) in protein detection was introduced,and its detection methods and time to achieve the desired results.Believe that with the technical update of the invention and creation,molecular imprinting electrochemical sensor detection field will be expanded to more areas.

Key words: molecular imprinting, electrochemical sensors, protein

摘要： 分子印迹电化学传感器是分子印迹技术与分析传感器技术相结合的一种先进技术，它结合分子印迹的优点，避免了传统传感器的缺点，提高了电化学传感器的选择性和灵敏度，并且缩短了响应时间，更因其设计简单、经济实用等优点受到越来越多领域的欢迎。本文介绍了分子印迹传感器的5种常用的制备方法，包括涂层法、原位聚合法、电聚合法、溶胶-凝胶法和自组装法以及这5种方法在实际中的应用，重点介绍了4种分子印迹传感器（MIPs电容/阻抗型、MIPs电导型、MIPs电位型、MIPs电流型）在蛋白质检测上的应用，并且其检测方式以及时间都达到了预期的效果，相信随着技术的更新发明与创造，分子印迹电化学传感器的检测领域会拓展到更多的领域。

关键词: 分子印迹, 电化学传感器, 蛋白质

CLC Number:

TQ317

LIU Yanli, LI Xiaojun, HE Xiaorong, LI Yanbin, LI Hongchao. The fabrication of molecularly imprinted electochemical sensor and its application in protein detection[J]. Chemical Industry and Engineering Progress, 2017, 36(07): 2533-2539.

刘艳丽, 李小军, 贺晓荣, 李延斌, 李红朝. 分子印迹电化学传感器制备及在蛋白质检测上的应用[J]. 化工进展, 2017, 36(07): 2533-2539.

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