Pickering乳液在药物载体制备方面的研究进展

doi:10.16085/j.issn.1000-6613.2017-0522

摘要/Abstract

摘要： Pickering乳液具有成本低、稳定性好、毒性小等优点，广泛应用于化妆品、食品、医药等方面。利用Pickering乳液制备药物载体操作简单，可改善难溶药物的溶出，对药物具有一定的缓释效果，其在药物载体方面具有广阔的发展前景。本文综述了近些年Pickering乳液在药物载体方面的研究进展，首先简要介绍了药物缓释技术及Pickering乳液性质；然后重点分析了不同固体粒子稳定的Pickering乳液在载药微球制备中的研究；还探讨了Pickering乳液在制备载药凝胶、载药多孔支架以及载药乳剂等方面的应用；最后对Pickering乳液制备药物载体方面作出展望，随着该技术相关研究的发展和成熟，药物载体的稳定性、生物相容性等问题的突破，利用Pickering乳液制备药物载体的方法技术将更有利于药物载药体系的发展。

关键词: Pickering乳液, 固体粒子, 药物载体, 缓释

Abstract: Pickering emulsion is widely used in food,cosmetics and pharmaceutical fields due to its low cost,good stability and low toxicity. Preparation of drug carriers by Pickering emulsion offers great potential in the pharmaceutical industry since the preparation method is simple to operate,improved the dissolution of poorly soluble drugs,and sustained release property. Recent applications of Pickering emulsion in the field of drug carrier are outlined in this review. Firstly,drug delivery systems and properties of Pickering emulsion are briefly introduced. Then drug-carrying microspheres based on Pickering emulsion and stabilized by different solid particles are discussed in detail. In addition,the applications of Pickering emulsion in the preparation of drug-carrying gels,drug-carrying porous scaffolds and drug-carrying emulsions are also discussed. Finally,research directions of drug carriers via the Pickering emulsion are suggested. With the further studies of Pickering emulsion,the stability and biocompatibility of drug carriers can be improved.

Key words: Pickering emulsion, solid particles, drug carrier, sustained release

中图分类号:

TQ460.1

戈明亮, 汤微. Pickering乳液在药物载体制备方面的研究进展[J]. 化工进展, 2017, 36(12): 4586-4591.

GE Mingliang, TANG Wei. Progress in preparation of drug carriers based on Pickering emulsion[J]. Chemical Industry and Engineering Progress, 2017, 36(12): 4586-4591.

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