关键词: 磺基甜菜碱, 羰基还原胺化, 合成, 磺基甜菜碱, 羰基还原胺化, 合成

Abstract: Sulphobetaine is widely used in the fields of detergent，cosmetic and oil recovery because of its mildness，high interfacial activity，and strong capacity for tolerating the divalent cations，and so on. In this paper，the progress in the two-step synthesis technology of sulphobetaine using amine as raw material is discussed，four methods to produce the intermidate (tertiary amine) were described particularly，including halogenate-amination，catalytic amination of alcohols，formaldehyde hydrogenation and reductive amination of carbonyl compounds. The problem and the industrialization feasibility of each synthesis technology were discussed in terms of raw materials，yield，environmental protection property and practicalities. Besides，sodium 3-chloro-2-hydroxy propanesulfonate and propane sultone used in the quaterisation of tertiary amine were compared in detail. It can be concluded that the further research shall be focused on the reductive amination of carbonyl compounds for its green property. 3-Chloro-2-hydroxy propanesulfonate is a good reagent for quaterisation.

Key words: sulphobetaine, reductive amination of carbonyl compounds, synthesis, sulphobetaine, reductive amination of carbonyl compounds, synthesis