发酵液中乳酸的分离提取研究进展

doi:10.16085/j.issn.1000-6613.2016.09.004

摘要/Abstract

摘要： 乳酸是合成聚乳酸的原料，生物法制备乳酸是目前工业上生产乳酸的主要方法。但乳酸发酵液成分复杂，后续的分离提纯过程成了制约乳酸生产的技术瓶颈和难点，也决定着乳酸的品质与收率。本文对乳酸发酵液的主要的分离提取工艺进行了介绍，包括结晶分离技术、酯化水解法、萃取法、分子蒸馏法、膜分离法、吸附法及与发酵耦合的原位分离技术。并提出单一的分离技术很难有效提取乳酸，需将多种技术集成、改良提纯工艺路线。其中，将各种新型高效的集成技术与发酵过程的有机结合，实现连续或半连续的发酵过程，可提高乳酸产率和产品质量，有望形成高效率、高品质、低污染、低能耗、可工业化的乳酸提纯工艺路线。

关键词: 乳酸, 分离/提取, 发酵液

Abstract: Lactic acid is the raw material for synthesis of poly-(lactic acid). Biological processes are the main industrial method for lactic acid production. Due to the complex composition of fermentation broth,separation and purification of lactic acid from fermentation broth become the key technologies for biosynthesis. They also determine the quality and yield of lactic acid. In this paper,separation methods of lactic acid from fermentation broth are discussed,including crystallization,esterification, extraction,molecular distillation,membrane separation,adsorption and in situ product removal technology combining fermentation with the above separation methods. However,a single technology cannot efficiently extract lactic acid. It has to combine multiple technologies and improve the process route. One of the methods is to combine efficient integration technologies with the fermentation process,realizing continuous or semi-continuous production. This can improve the productivity and quality of lactic acid,and also form a set of purification processes that are efficient,high-quality, low-pollution,low energy-consuming and also feasible for industrial production.

Key words: lactic acid, separation/purification, fermentation broth

中图分类号:

TQ923

孙启梅, 乔凯, 王领民, 高大成, 王崇辉. 发酵液中乳酸的分离提取研究进展[J]. 化工进展, 2016, 35(09): 2656-2662.

SUN Qimei, QIAO Kai, WANG Lingmin, GAO Dacheng, WANG Chonghui. Advances in separation and purification of lactic acid from fermentation broths[J]. Chemical Industry and Engineering Progree, 2016, 35(09): 2656-2662.

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