关键词: 荧烷, 2-羟基-4-(N-乙基-N-异丁基)氨基-2'-羧基二苯酮, 中间体, 压热敏染料, 合成, 反应, TLC

Abstract: There are few reports about the synthesis of fluorane intermediate in China.2-hydroxybenzoyl-4-(N-ethyl-N-isobutyl) amino-2'-carboxyl benzophenone is a very important intermediate of fluorane thermal-pressure sensitive dyes,it was synthesized with N-ethyl-N-isobutyl-m-aminophenol m-aminophenol and phthalic anhydride.After the synthesis reaction we used NaOH solution to purify the product.HPCE was used to detect the purity of 2-hydroxybenzoyl-4-(N-ethyl-N-isobutyl) amino-2'-carboxyl benzophenone and the purity achieves 96.36%(area normalization method).TLC was used to monitor the reaction process and we used UV to confirm the conclusion of TLC,the effect of material ratio,temperature and time were discussed in detail.we concluded that in the synthetic reaction of benzophenone,the best reaction condition was the mole ratio of N-ethyl-N-isobutyl-m-aminophenol m-aminophenol and phthalic anhydride was 1:1.5,temperature was 110℃,time was 15h.In the decomposition reaction of by-products,the best reaction condition was the concentration of NaOH solution was 33.3%,the mass ratio of N-ethyl-N-isobutyl-m-aminophenol m-aminophenol and NaOH was 1:7.5,temperature was 90℃,time was 9h.At last the target product was confirmed by IR and UV.

Key words: fluorane, 2-hydroxybenzoyl-4-(N-ethyl-N-isobutyl) amino-2'-carboxyl benzophenone, intermediate, thermal-pressure sensitive dyes, synthesis, reaction, TLC(thin layer chromatography)