化工进展

• 材料科学与技术 • 上一篇    下一篇

缓释铜的凹土/海藻酸钠复合微球的制备及性能测试

徐婷婷,李治方,吴 洁,陈 静   

  1. 淮阴工学院,江苏 淮阴 223003
  • 出版日期:2013-02-05 发布日期:2013-02-05

Investigation on the preparation and characterization of palygorskite/sodium alginate composite microspheres for the sustained releasing of Cu2+

XU Tingting,LI Zhifang,WU Jie,CHEN Jing   

  1. Department of Life Science and Chemical Engineering,Huaiyin 223003,Jiangsu,China
  • Online:2013-02-05 Published:2013-02-05

摘要: 海藻酸钠微球是传统缓控释制剂,提高凝胶强度和增大毛细孔隙率是改善其缓控释性能的有效途径。本文以原子吸收分光光度法辅以微观形貌表征(SEM)和溶胀实验等分析方法,探讨了凹土/海藻酸钠复合微球用于以生命体中微量元素(Cu2+)控释的可行性,并进行了缓释机理分析。实验结果表明,凹土具有显著改善微球的凝胶强度和缓释性能的作用;与海藻酸钠微球相比,复合微球的吸附率由91.82%提高到94.60%,在2 h之内的释放率由66.35%降低到22.78%,表明凹土/海藻酸钠复合微球可作为理想的长效缓释药物的载体。

关键词: 缓释微球, 铜, 凹土, 海藻酸钠

Abstract: Sodium alginate microspheres are traditional sustained releasing materials;gel strength enhancement and capillary porosity increment are effective ways to improve their sustained releasing ability. Atomic adsorption spectrometry along with micro appearance characterization and swelling experiments are used to explore the feasibility of sustained releasing of Cu2+ of sodium alginate/palygorskite microspheres. Palygorskite improves the gel strength of the microspheres as well as their sustained releasing ability. Comparing with the sodium alginate microspheres,the composite ones prepared with proposed method had better adsorption ability (from 91.82% to 94.60%). In addition,the cumulative releasing percentage within 2 hours decreased from 66.35% to 22.78%. Thus,palygorskite/sodium alginate composite microspheres can be an ideal carrier for long term sustained releasing drugs.

Key words: sustained releasing microspheres, copper, palygorskite, sodium alginate

京ICP备12046843号-2;京公网安备 11010102001994号
版权所有 © 《化工进展》编辑部
地址:北京市东城区青年湖南街13号 邮编:100011
电子信箱:hgjz@cip.com.cn
本系统由北京玛格泰克科技发展有限公司设计开发 技术支持:support@magtech.com.cn