关键词: 缓释微球, 铜, 凹土, 海藻酸钠

Abstract: Sodium alginate microspheres are traditional sustained releasing materials；gel strength enhancement and capillary porosity increment are effective ways to improve their sustained releasing ability. Atomic adsorption spectrometry along with micro appearance characterization and swelling experiments are used to explore the feasibility of sustained releasing of Cu2+ of sodium alginate/palygorskite microspheres. Palygorskite improves the gel strength of the microspheres as well as their sustained releasing ability. Comparing with the sodium alginate microspheres，the composite ones prepared with proposed method had better adsorption ability (from 91.82% to 94.60%). In addition，the cumulative releasing percentage within 2 hours decreased from 66.35% to 22.78%. Thus，palygorskite/sodium alginate composite microspheres can be an ideal carrier for long term sustained releasing drugs.

Key words: sustained releasing microspheres, copper, palygorskite, sodium alginate