微流控法可控构建微尺度功能材料

doi:10.16085/j.issn.1000-6613.2018-1267

化工进展 ›› 2019, Vol. 38 ›› Issue (01): 421-433.DOI: 10.16085/j.issn.1000-6613.2018-1267

微流控法可控构建微尺度功能材料

汪伟^1,²(),苏瑶瑶¹,刘壮^1,²,巨晓洁^1,²,谢锐^1,²,褚良银^1,²()

1. 四川大学化学工程学院，四川成都 610065
2. 四川大学高分子材料工程国家重点实验室，四川成都 610065

收稿日期:2018-06-20 修回日期:2018-10-26 出版日期:2019-01-05 发布日期:2019-01-05
通讯作者: 褚良银
作者简介:汪伟（1984—），男，博士，副教授，博士生导师，研究方向为微流控技术和功能材料。E-mail：<email>wangwei512@scu.edu.cn</email>。|褚良银，教授，博士生导师，研究方向为膜科学与技术、智能化控释系统、微流控技术、传质与分离、生物材料。E-mail：<email>chuly@scu.edu.cn</email>。
基金资助:
国家自然科学基金重大研究计划重点支持项目(91434202);国家自然科学基金重大研究计划重点支持项目（91434202）。

Controllable microfluidic fabrication of microscale functional materials

Wei WANG^1,²(),Yaoyao SU¹,Zhuang LIU^1,²,Xiaojie JU^1,²,Rui XIE^1,²,Liangyin CHU^1,²()

1. School of Chemical Engineering，Sichuan University，Chengdu 610065, Sichuan, China
2. State Key Laboratory of Polymer Materials Engineering，Sichuan University，Chengdu 610065, Sichuan, China

Received:2018-06-20 Revised:2018-10-26 Online:2019-01-05 Published:2019-01-05
Contact: Liangyin CHU

摘要/Abstract

摘要：

微尺度功能材料的功能取决于材料结构和组分的精确协同匹配，但如何实现微尺度空间上多样化材料结构的精确调控和功能组分的精确协同定位仍是一大挑战。本文综述了微流控法可控构建新型微尺度功能材料的研究新进展，重点介绍了基于微流控制备的微尺度相界面体系中材料结构和组分的精确协同匹配来设计构建具有独特结构和功能的微尺度功能材料的新策略。首先介绍了以液滴状和液流状微尺度相界面体系为模板，分别可控构建具有多样化结构的功能微颗粒和微纤维的进展；然后介绍了以微通道受限空间内微尺度相界面体系为模板、原位可控构建微通道膜和功能微阀的进展。今后研究应关注于微尺度相界面体系的结构扩展创新及其规模化制备技术。

关键词: 微流体学, 模板合成, 功能材料, 乳液, 界面

Abstract:

The functions of microscale functional materials are determined by an accurate and synergistic combination of their structures and the constitute components. However, how to accurately manipulate diverse structures, and synergistically integrate diverse components in micro-space still remains challenging. This review summarizes recent progress on the microfluidic fabrication of novel microscale functional materials. Emphases are placed on the new strategies for fabricating microscale functional materials with unique structure and function, through accurate and synergistic combination of the structures and the constitute components. First, controllable fabrication of functional microparticles and microfibers with diverse structures, respectively from microdroplet templates and microflow jet templates is introduced. Then, in situ fabrication of functional membrane-in-chip and microvalves using confined microscale interfacial systems in microchannel as templates is introduced. Further study should focus on the creation of microscale interfacial systems with more diverse structures and their scale-up techniques.

Key words: microfluidics, template synthesis, functional materials, emulsions, interface

中图分类号:

TQ031.2
TB34

汪伟, 苏瑶瑶, 刘壮, 巨晓洁, 谢锐, 褚良银. 微流控法可控构建微尺度功能材料[J]. 化工进展, 2019, 38(01): 421-433.

Wei WANG, Yaoyao SU, Zhuang LIU, Xiaojie JU, Rui XIE, Liangyin CHU. Controllable microfluidic fabrication of microscale functional materials[J]. Chemical Industry and Engineering Progress, 2019, 38(01): 421-433.

图/表 11

图1 模块化微流控装置[4,25]

图2 模块化微流控装置可控制备多重乳液液滴[4,25]

图3 微流控法可控构建单腔室微颗粒[12,13,27]

图4 微流控法可控构建多腔室水凝胶微颗粒[15,28]

图5 微流控法可控构建多腔室囊泡微颗粒[29,30]

图6 微流控法构建具有可控孔-壳型结构的单孔功能微颗粒[33]

图7 微流控法构建具有可控分级式多孔结构的功能微颗粒[18]

图8 微流控法可控构建具有中空结构的功能微纤维[34,35]

图9 微流控法可控构建具有豆荚状和仿蜘蛛丝结构的功能微纤维[34,36]

图10 微流控法可控构建微通道智能膜[23]

图11 微流控法原位构建微通道智能微阀[22]

参考文献 36

1	ATENCIA J , BEEBE D . Controlled microfluidic interfaces[J]. Nature, 2005(7059): 648-655.
2	WHITESIDES G M . The origins and the future of microfluidics[J]. Nature, 2006, 442(7101): 368-373.
3	ABATE A R , WEITZ D A . High‐order multiple emulsions formed in poly(dimethylsiloxane) microfluidics [J]. Small, 2009, 5(18): 2030-2032.
4	WANG W , XIE R , JU X J , et al . Controllable microfluidic production of multicomponent multiple emulsions [J]. Lab on a Chip, 2011, 11(9): 1587-1592.
5	XU S , NIE Z , SEO M , et al . Generation of monodisperse particles by using microfluidics: control over size, shape, and composition[J]. Angewandte Chemie International Edition, 2005, 44(25): 734-738.
6	WU F , WANG W , LIU L , et al . Monodisperse hybrid microcapsules with ultrathin shell of submicron thickness for rapid enzyme reaction[J]. Journal of Materials Chemistry B, 2015, 3(5): 796-803.
7	XU Q , HASHIMOTO M , DANG T T , et al . Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery[J]. Small, 2009, 5(13): 1575-1581.
8	CHOI C H , JUNG J H , KIM D W , et al . Novel one-pot route to monodisperse thermosensitive hollow microcapsules in a microfluidic system[J]. Lab on a Chip, 2008, 8(9): 1544-1551.
9	WANG W , ZHANG M J , CHU L Y . Functional polymeric microparticles engineered from controllable microfluidic emulsions[J]. Accounts of Chemical Research, 2014, 47(2): 373-384.
10	LIU Z , LIU L , JU X J , et al . K⁺-recognition capsules with squirting release mechanisms[J]. Chemical Communications, 2011, 47(45): 12283-12285.
11	LIU L , YANG J , JU X J , et al . Monodisperse core-shell chitosan microcapsules for pH-responsive burst release of hydrophobic drugs[J]. Soft Matter., 2011, 7(10): 4821-4827.
12	WANG W , LIU L , DR X J J , et al . A novel thermo-induced self-bursting microcapsule with magnetic-targeting property[J]. ChemPhysChem, 2009, 10(14): 2405-2409.
13	LIU L , WANG W , JU X J , et al . Smart thermo-triggered squirting capsules for nanoparticle delivery[J]. Soft Matter., 2010, 6(16): 3759-3763.
14	MOU C L , HE X H , JU X J , et al . Change in size and structure of monodisperse poly(N-isopropylacrylamide) microcapsules in response to varying temperature and ethyl gallate concentration[J]. Chemical Engineering Journal, 2012, 210(6): 212-219.
15	HE F , WANG W , HE X H , et al . Controllable multicompartmental capsules with distinct cores and shells for synergistic release [J]. ACS Applied Materials & Interfaces, 2016, 8(13): 8743-8754.
16	WANG W , LUO T , JU X J , et al . Microfluidic preparation of multicompartment microcapsules for isolated co-encapsulation and controlled release of diverse components[J]. International Journal of Nonlinear Sciences and Numerical Simulation, 2012, 13(5): 325-332.
17	SUN B J , SHUM H C , HOLTZE C , et al . Microfluidic melt emulsification for encapsulation and release of actives[J]. ACS Applied Materials & Interfaces, 2010, 2(12): 3411-3416.
18	ZHANG M J , WANG W , YANG X L , et al . Uniform microparticles with controllable highly interconnected hierarchical porous structures[J]. ACS Applied Materials & Interfaces, 2015, 7(25): 13758-13767.
19	LEE D , WEITZ D A . Nonspherical colloidosomes with multiple compartments from double emulsions[J]. Small, 2009, 5(17): 1932-1935.
20	NIE Z , XU S , SEO M , et al . Polymer particles with various shapes and morphologies produced in continuous microfluidic reactors[J]. Journal of the American Chemical Society, 2005, 127(22): 8058-8063.
21	WU F , JU X J , HE X H , et al . A novel synthetic microfiber with controllable size for cell encapsulation and culture[J]. Journal of Materials Chemistry B, 2016, 4(14): 2455-2465.
22	LIN S , WANG W , JU X J , et al . Ultrasensitive microchip based on smart microgel for real-time online detection of trace threat analytes[J]. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113(8): 2023-2028.
23	SUN Y M , WANG W , WEI Y Y , et al . In situ fabrication of temperature- and ethanol-responsive smart membrane in microchip[J]. Lab on a Chip, 2014, 14(14): 2418-2427.
24	LIN S , WANG W , JU X J , et al . A simple strategy for in situ fabrication of a smart hydrogel microvalve within microchannels for thermostatic control[J]. Lab on a Chip, 2014, 14(15): 2626-2634.
25	MENG Z J , WANG W , LIANG X , et al . Plug-n-play microfluidic systems from flexible assembly of glass-based flow-control modules[J]. Lab on a Chip, 2015, 15(8): 1869-1878.
26	ZHANG M J , WANG W , XIE R , et al . Microfluidic fabrication of monodisperse microcapsules for glucose-response at physiological temperature[J]. Soft Matter, 2013, 9(16): 4150-4159.
27	WEI J , JU X J , ZOU X Y , et al . Multi-stimuli-responsive microcapsules for adjustable controlled-release[J]. Advanced Functional Materials, 2014, 24(22): 3312-3323.
28	MOU C L , WANG W , LI Z L , et al . Trojan-horse-like stimuli-responsive microcapsules[J]. Advanced Science, 2018. DOI:10.1002/advs. 1700960. DOI URL
29	DENG N N , YELLESWARAPU M , HUCK W T S . Monodisperse uni- and multicompartment liposomes[J]. Journal of the American Chemical Society, 2016, 138(24): 7584-7591.
30	DENG N N , YELLESWARAPU M , ZEHNG L , et al . Microfluidic assembly of monodisperse vesosomes as artificial cell models[J]. Journal of the American Chemical Society, 2017, 139(2): 587-590.
31	DENG N N , HUCK W T S . Microfluidic formation of monodisperse coacervate organelles in liposomes [J]. Angewandte Chemie International Edition, 2017, 56(33): 9736-9740.
32	DENG N N , VIBHUTE M A , ZEHNG L , et al . Microfluidic assembly of monodisperse vesosomes as artificial cell models[J]. Journal of the American Chemical Society, 2018, 140(24): 7399-7382.
33	WANG W , ZHANG M J , XIE R , et al . Hole-shell microparticles from controllably evolved double emulsions [J]. Angewandte Chemie International Edition, 2013, 52(31): 8084-8087.
34	HE X H , WANG W , DENG K , et al . Microfluidic fabrication of chitosan microfibers with controllable internals from tubular to peapod-like structures[J]. RSC Advances, 2014, 5(2): 928-936.
35	MENG Z J , WANG W , XIE R , et al . Microfluidic generation of hollow Ca-alginate microfibers[J]. Lab on a Chip, 2016, 16(14): 2673-2681.
36	HE X H , WANG W , LIU Y M , et al . Microfluidic fabrication of bio-inspired microfibers with controllable magnetic spindle-knots for 3D assembly and water collection[J]. ACS Applied Materials & Interfaces, 2015, 7(31): 17471-17481.

[1]	王太, 苏硕, 李晟瑞, 马小龙, 刘春涛. 交流电场中贴壁气泡的动力学行为[J]. 化工进展, 2023, 42(S1): 133-141.
[2]	王家庆, 宋广伟, 李强, 郭帅成, DAI Qingli. 橡胶混凝土界面改性方法及性能提升路径[J]. 化工进展, 2023, 42(S1): 328-343.
[3]	赵健, 卓泽文, 董航, 高文健. 含蜡原油及其乳状液体系微观结构观测的新方法[J]. 化工进展, 2023, 42(8): 4372-4384.
[4]	吴亚, 赵丹, 方荣苗, 李婧瑶, 常娜娜, 杜春保, 王文珍, 史俊. 用于复杂原油乳液的高效破乳剂开发及应用研究进展[J]. 化工进展, 2023, 42(8): 4398-4413.
[5]	陈森, 殷鹏远, 杨证禄, 莫一鸣, 崔希利, 锁显, 邢华斌. 功能固体材料智能合成研究进展[J]. 化工进展, 2023, 42(7): 3340-3348.
[6]	李吉焱, 景艳菊, 邢郭宇, 刘美辰, 龙永, 朱照琪. 耐盐型太阳能驱动界面光热材料及蒸发器的研究进展[J]. 化工进展, 2023, 42(7): 3611-3622.
[7]	李瑞东, 黄辉, 同国虎, 王跃社. 原油精馏塔中铵盐吸湿特性及其腐蚀行为[J]. 化工进展, 2023, 42(6): 2809-2818.
[8]	陶梦琦, 刘美红, 康宇驰. 基于micro-PIV的微通道内流体绕流单微圆柱和并联双微圆柱流场特性[J]. 化工进展, 2023, 42(6): 2836-2844.
[9]	杨扬, 孙志高, 李翠敏, 李娟, 黄海峰. 静态条件下表面活性剂OP-13促进HCFC-141b水合物生成[J]. 化工进展, 2023, 42(6): 2854-2859.
[10]	符淑瑢, 王丽娜, 王东伟, 刘蕊, 张晓慧, 马占伟. 析氧助催化剂增强光阳极光电催化分解水性能研究进展[J]. 化工进展, 2023, 42(5): 2353-2370.
[11]	梁贻景, 马岩, 卢展烽, 秦福生, 万骏杰, 王志远. La_1-_x Sr _x MnO₃钙钛矿涂层的抗结焦性能[J]. 化工进展, 2023, 42(4): 1769-1778.
[12]	赵珍珍, 郑喜, 王雪琪, 王涛, 冯英楠, 任永胜, 赵之平. 聚酰胺复合膜微孔支撑基底的研究进展[J]. 化工进展, 2023, 42(4): 1917-1933.
[13]	高婷婷, 蒋振, 吴晓毅, 郝婷婷, 马学虎, 温荣福. 微乳液脉动热管应用于锂离子电池的散热性能[J]. 化工进展, 2023, 42(3): 1167-1177.
[14]	章建忠, 许升, 樊家澍, 费振宇, 王堃, 黄建, 崔峰波, 冉文华. 玻璃纤维浸润剂的分析与表征技术进展[J]. 化工进展, 2023, 42(2): 821-838.
[15]	范思强, 彭绍忠, 彭冲, 胡永康. 废塑料高附加值利用技术研究进展[J]. 化工进展, 2023, 42(2): 1020-1027.

微流控法可控构建微尺度功能材料

Controllable microfluidic fabrication of microscale functional materials

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

图/表 11

参考文献 36

相关文章 15

编辑推荐

Metrics

本文评价