壳聚糖双胍盐酸盐络合碘制备及抑菌性能

doi:10.16085/j.issn.1000-6613.2015.07.028

化工进展 ›› 2015, Vol. 34 ›› Issue (07): 1979-1982.DOI: 10.16085/j.issn.1000-6613.2015.07.028

壳聚糖双胍盐酸盐络合碘制备及抑菌性能

徐宁宁, 谢琳琳, 唐阳, 赛明泽, 丁德润

上海工程技术大学化学化工学院, 上海 201620

收稿日期:2014-11-17 修回日期:2014-11-24 出版日期:2015-07-05 发布日期:2015-07-05
通讯作者: 丁德润,教授,主要从事天然高分子材料的研究。E-mail:dingderun@sues.edu.cn。
作者简介:徐宁宁(1987—),男,硕士研究生。
基金资助:
上海工程技术大学研究生科研创新专项(14KY0416)。

Preparation and antibacterial properties of chitosan biguanide hydrochloride complex with iodine

XU Ningning, XIE Linlin, TANG Yang, SAI Mingze, DING Derun

College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China

Received:2014-11-17 Revised:2014-11-24 Online:2015-07-05 Published:2015-07-05

摘要/Abstract

摘要： 以壳聚糖(CTS)和双氰胺为原料, 在一定温度下通过亲核加成合成壳聚糖双胍盐酸盐(CGH)衍生物, CGH与不同浓度的碘乙醇溶液制备改性壳聚糖的碘络合物(CGH-I₂)。用IR光谱、XRD、TG和DTG对衍生物进行表征, 通过碘量法测CGH与碘络合的质量比。碘含量分析表明:碘乙醇溶液浓度为0.02mol/L 时, CGH与碘络合的最大质量比为m(CGH):m(I₂)=1:0.46。抑菌性测试表明:CGH-I₂对大肠杆菌和金黄色葡萄球菌抑菌环直径分别为(18±1)mm和(21±1)mm, 敏感度均为高度敏感。

关键词: 壳聚糖双胍盐酸盐, 碘, 络合, 抑菌, 功能材料

Abstract: A novel derivative, chitosan biguanide hydrochloride (CGH), was synthesized by using chitosan (CTS) and dicyandiamide in a simple nucleophilic addition process at a certain temperature. Then, the complex compound (CGH-I₂) was obtained by immersing CGH in iodine ethanol solution with different concentrations. The properties of CGH were characterized by means of IR, XRD, TG and DTG. The analysis of iodine content shows that the maximum mass ratio of CGH complex with iodine was m (CGH):m (I₂) =1:0. 46 when the concentration of iodine ethanol solution was 0.02mol/L. The antimicrobial test results show that the antibacterial diameters of the CGH-I₂against E. coli and Staphylococcus aureus were (18±1)mm and (21±1)mm respectively, with a high sensitivity of bacteriostasis.

Key words: chitosan biguanide hydrochloride, iodine, complex, antibacterial, functional materials

中图分类号:

O636.1

徐宁宁, 谢琳琳, 唐阳, 赛明泽, 丁德润. 壳聚糖双胍盐酸盐络合碘制备及抑菌性能[J]. 化工进展, 2015, 34(07): 1979-1982.

XU Ningning, XIE Linlin, TANG Yang, SAI Mingze, DING Derun. Preparation and antibacterial properties of chitosan biguanide hydrochloride complex with iodine[J]. Chemical Industry and Engineering Progree, 2015, 34(07): 1979-1982.

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壳聚糖双胍盐酸盐络合碘制备及抑菌性能

Preparation and antibacterial properties of chitosan biguanide hydrochloride complex with iodine

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