关键词: 多相催化, 不对称氢化, 手性催化剂, 酒石酸, 金鸡纳生物碱

Abstract: Chirally modified metal catalysts are one of most developed and promising heterogeneous enantioselective catalysts. The recent progress of the enantioselective hydrogenation of β-ketoesters on tartaric acid modified nickel catalysts, the enantioselective hydrogenation of α-ketoesters using cinchona alkaloid modified platinum, and the enantioselective hydrogenation of carbon-carbon and carbon-nitrogen double bonds using cinchona alkaloid modified palladium catalysts are summarized. The influential factors of the catalyst systems are briefly introduced, and the enantioselection mechanism in tartaric acid modified nickel catalysts and cinchona alkaloids modified platinum catalysts are also discussed. In addition, further research work in heterogeneous asymmetric hydrogenation should be focused on development of high efficiency catalysts and investigation of reaction mechanism.

Key words: heterogeneous catalysis, enantioselective hydrogenation, chiral catalyst, tartaric acid, cinchona alkaloids