化工进展 ›› 2018, Vol. 37 ›› Issue (10): 3980-3987.DOI: 10.16085/j.issn.1000-6613.2017-2404

• 生物与医药化工 • 上一篇    下一篇

TiO2纳米结构作为载体在药物缓控释传递系统的应用

孟戎茜1,2, 李巧玲3, 晋日亚4   

  1. 1 中北大学化学工程与技术学院, 山西 太原 030051;
    2 太原工业学院化学与化工系, 山西 太原 030051;
    3 中北大学理学院, 山西 太原 030051;
    4 中北大学环境与安全学院, 山西 太原 030051
  • 收稿日期:2017-11-20 修回日期:2017-12-13 出版日期:2018-10-05 发布日期:2018-10-05
  • 通讯作者: 李巧玲,教授,博士生导师,研究方向为功能纳米复合材料。
  • 作者简介:孟戎茜(1985-),女,博士研究生,讲师。E-mail:670382876@qq.com。
  • 基金资助:
    国家自然科学基金项目(51272239)。

Progress of titanium dioxide nanostructures as carriers in sustained and controlled drug-release delivery system

MENG Rongqian1,2, LI Qiaoling3, JIN Riya4   

  1. 1 School of Chemical Engineering and Technology, North University of China, Taiyuan 030051, Shanxi, China;
    2 Department of Chemistry and Chemical Engineering, Taiyuan Institute of Technology, Taiyuan 030051, Shanxi, China;
    3 School of Science, North University of China, Taiyuan 030051, Shanxi, China;
    4 School of Environment and Safety Engineering, North university of China, Taiyuan 030051, Shanxi, China
  • Received:2017-11-20 Revised:2017-12-13 Online:2018-10-05 Published:2018-10-05

摘要: TiO2纳米结构以其生物相容性好、机械强度高、耐热耐腐蚀等优点,在药物缓控释传递系统载体应用方面引起广泛关注。结合近几年研究报道,本文将单一和功能化TiO2纳米结构作为药物缓控释载体进行分类,简述了制备方法、结构表征、载药方法、释药机理等,分析了功能化TiO2纳米结构修饰结合外界刺激响应在药物缓控释系统的应用。结果表明,相比单一结构,功能化修饰后的TiO2纳米结构具有载药率高、缓控释效果明显、生物相容性好等优点;功能化修饰结合外界刺激响应,进一步提升药物缓控释效果;而相比单一和双重刺激响应,多重刺激响应能够更好地实现局部靶向释药。最后预测该纳米结构作为药物缓控释传递系统载体的研究发展方向并指出目前实现临床应用所面临的问题。

关键词: TiO2纳米结构, 药物传递系统, 功能修饰, 缓控释, 刺激响应

Abstract: Due to its advantages of good biocompatibility, high mechanical strength, heat and corrosion resistance, the titanium dioxide nanostructures (TNSs) as drug carriers have been attracted more attention in the aspect of sustained and controlled drug-release delivery system. Referring to the recent literatures, single and functional TNSs as carriers for sustained and controlled drug-release are classified, and their preparation methods, structure characterization, drug loading methods, drug releasing mechanism et al. are briefly introduced. Moreover, the application of functionalized TNSs modification combined with external stimuli response in drug sustained and controlled drug-release system are analyzed in detail. The results showed the functional TNSs have the advantages of higher drug loading rate, more obvious sustained and controlled drug-release effect, and better biocompatibility. Functionalized TNSs modifications with external stimuli response are able to further enhance sustained and controlled drug-release effect. In addition, compared to the single and double stimuli-responsive, multiple stimuli-responsive has a better effect on the local target drug-release. Finally, the development trend of TNSs as sustained and controlled drug-release carriers and the current problems to solve in order to achieve the clinical application are discussed.

Key words: titanium dioxide nanostructures, drug delivery system, functional modification, sustained and controlled drug-release, stimuli-response

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