智能印迹聚合物及其外场强化的识别机制研究进展

doi:10.16085/j.issn.1000-6613.2021-0007

化工进展 ›› 2021, Vol. 40 ›› Issue (12): 6752-6764.DOI: 10.16085/j.issn.1000-6613.2021-0007

智能印迹聚合物及其外场强化的识别机制研究进展

卞维柏¹^,²^,³(), 陈一帆¹, 潘建明²^,³()

^1.常州工学院光电工程学院，江苏常州 213032
^2.江苏大学化学化工学院，江苏镇江 212013
^3.江苏省农用激素工程技术研究中心有限公司，江苏常州 213022

收稿日期:2021-01-04 修回日期:2021-02-18 出版日期:2021-12-05 发布日期:2021-12-21
通讯作者: 潘建明
作者简介:卞维柏（1988—），男，博士后，讲师，研究方向为选择性吸附分离。E-mail：bianwb@czu.cn。
基金资助:
国家优秀青年科学基金(21822807);国家自然科学基金(21706099);江苏省自然科学基金(BK20190160);中国博士后基金(2019M651744);常州市重点研发计划（社会发展）(CE20205030);江苏省博士后基金(2021K354C)

Research progress in intelligent imprinted polymers and their recognition mechanisms under external field enhancement

BIAN Weibai¹^,²^,³(), CHEN Yifan¹, PAN Jianming²^,³()

^1.School of Electrical and Optoelectronic Engineering, Changzhou Institute of Technology, Changzhou 213032, Jiangsu, China
^2.School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, Jiangsu, China
^3.Jiangsu Agricultural Hormone Engineering Technology Research Center Company Limited, Changzhou 213022, Jiangsu, China

Received:2021-01-04 Revised:2021-02-18 Online:2021-12-05 Published:2021-12-21
Contact: PAN Jianming

摘要/Abstract

摘要：

智能印迹聚合物在外部环境刺激下对模板分子具有响应性分子识别吸附能力，在吸附分离、药物传递、检测、固相萃取、催化等应用领域有着广阔的前景。本文首先对分子印迹聚合物进行了综述并指出在外场强化过程中常规分子印迹聚合物很难通过改变结合位点来控制结合特性的问题，针对这个问题进而提出具有柔性位点的智能响应型印迹聚合物。随后以具有不同响应功能的智能印迹聚合物为出发点，对磁、热、光、pH、生物大分子等单因子及双重因子响应功能印迹聚合物在外场强化过程中的响应与识别机制分别进行分析与总结，并综述了近些年来这些智能印迹聚合物在不同应用领域中相关研究工作进展。最后，基于不同响应功能的智能印迹聚合物的现状问题，对智能印迹聚合物在材料制备与理论两方面分别进行了展望。

关键词: 分子印迹技术, 智能印迹聚合物, 刺激响应识别机制, 外场强化

Abstract:

Intelligent imprinted polymers have stimuli-responsive molecular recognition and adsorption capability for template molecules under environmental stimuli. They have a broad prospect in the application encompassing the fields of adsorption separation, drug delivery, detection, solid phase extraction, catalysis and so on. In this paper, molecularly imprinted polymers (MIPs) were reviewed and the significant drawback of MIPs that it was difficult for MIPs to deform the binding sites for the sake of controlling binding characteristics was pointed out. To solve this problem, intelligent responsive imprinted polymers with flexible sites were proposed. Then, the response and identification mechanisms for intelligent imprinted polymers with magnetic, thermal, optical, pH, biological macromolecules and other dual-factors response functions were analyzed and summarized, respectively. It also reviewed the research progress of these intelligent imprinted polymers in different applications in recent years. Finally, based on the problems of different intelligent imprinted polymers, it prospected the intelligent imprinted polymers in the future from the aspect of preparation and theory, respectively.

Key words: molecularly imprinted polymers (MIPs), intelligent imprinted polymers, stimulus response recognition mechanism, external-field enhancement

中图分类号:

TD98

卞维柏, 陈一帆, 潘建明. 智能印迹聚合物及其外场强化的识别机制研究进展[J]. 化工进展, 2021, 40(12): 6752-6764.

BIAN Weibai, CHEN Yifan, PAN Jianming. Research progress in intelligent imprinted polymers and their recognition mechanisms under external field enhancement[J]. Chemical Industry and Engineering Progress, 2021, 40(12): 6752-6764.

图/表 15

图1 分子印迹聚合物（MIPs）常规制备过程[14]

图2 Fe3O4@SiO2@ⅡP离子印迹聚合物的制备过程[36]

图3 亲水性磁性分子印迹聚合物的制备过程及其外加磁场去除水溶性酸性染料的应用[37]

图4 水相沉淀法制备热响应溶菌酶印迹纳米凝胶的原理图及其在体积相变温度附近的收缩/膨胀行为示意图[45]

图5 温敏型铜离子印迹聚合物识别吸附及脱附铜离子机理示意图[46]

图6 雌二醇分子印迹聚合物（E2-MIPs）的制备过程及其温度调控拉链式控制机理示意图[47]

图7 光响应锂离子印迹聚合物（P-IIPs）光调控吸附/释放锂离子机理示意图[49]

图8 紫外和可见光照射下偶氮苯衍单体反式-顺式异构化转变示意图[50]

图9 扑热息痛分子印迹水凝胶聚合物紫外及可见光调控下吸附与释放扑热息痛分子示意图[51]

图10 淀粉基印迹聚合物的合成过程及其pH响应结构的变化[54]

图11 聚丙烯酸（PAA）凝胶膨胀导致印迹聚合物颗粒受体底物亲和力改变示意图[55]

图12 蛋白响应印迹与非印迹聚合物识别蛋白示意图[59]

图13 磁/热双重响应功能的Cu2+印迹聚合物制备过程示意图[61]

图14 磁/pH双重响应功能的咖啡酸分子印迹聚合物制备过程[62]

图15 磁/光双重响应功能的磺胺嘧啶印迹聚合物制备过程[63]

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智能印迹聚合物及其外场强化的识别机制研究进展

Research progress in intelligent imprinted polymers and their recognition mechanisms under external field enhancement

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